Shi Su1, Peter M Kang1. 1. Cardiovascular Institute, Beth Israel Deaconess Medical Center and Harvard Medical School, 3 Blackfan Circle, CLS 910, Boston, MA 02215, USA.
Abstract
BACKGROUND: Nanomedicine is a field of science that uses nanoscale materials for the diagnosis and treatment of human disease. It has emerged as an important aspect of the therapeutics, but at the same time, also raises concerns regarding the safety of the nanomaterials involved. Recent applications of functionalized biodegradable nanomaterials have significantly improved the safety profile of nanomedicine. OBJECTIVE: Our goal is to evaluate different types of biodegradable nanomaterials that have been functionalized for their biomedical applications. METHOD: In this review, we used PubMed as our literature source and selected recently published studies on biodegradable nanomaterials and their applications in nanomedicine. RESULTS: We found that biodegradable polymers are commonly functionalized for various purposes. Their property of being naturally degraded under biological conditions allows these biodegradable nanomaterials to be used for many biomedical purposes, including bio-imaging, targeted drug delivery, implantation and tissue engineering. The degradability of these nanoparticles can be utilized to control cargo release, by allowing efficient degradation of the nanomaterials at the target site while maintaining nanoparticle integrity at off-target sites. CONCLUSION: While each biodegradable nanomaterial has its advantages and disadvantages, with careful design and functionalization, biodegradable nanoparticles hold great future in nanomedicine.
BACKGROUND: Nanomedicine is a field of science that uses nanoscale materials for the diagnosis and treatment of human disease. It has emerged as an important aspect of the therapeutics, but at the same time, also raises concerns regarding the safety of the nanomaterials involved. Recent applications of functionalized biodegradable nanomaterials have significantly improved the safety profile of nanomedicine. OBJECTIVE: Our goal is to evaluate different types of biodegradable nanomaterials that have been functionalized for their biomedical applications. METHOD: In this review, we used PubMed as our literature source and selected recently published studies on biodegradable nanomaterials and their applications in nanomedicine. RESULTS: We found that biodegradable polymers are commonly functionalized for various purposes. Their property of being naturally degraded under biological conditions allows these biodegradable nanomaterials to be used for many biomedical purposes, including bio-imaging, targeted drug delivery, implantation and tissue engineering. The degradability of these nanoparticles can be utilized to control cargo release, by allowing efficient degradation of the nanomaterials at the target site while maintaining nanoparticle integrity at off-target sites. CONCLUSION: While each biodegradable nanomaterial has its advantages and disadvantages, with careful design and functionalization, biodegradable nanoparticles hold great future in nanomedicine.
Authors: Samson N Dada; Godwin K Babanyinah; Michael T Tetteh; Victoria E Palau; Zachary F Walls; Koyamangalath Krishnan; Zacary Croft; Assad U Khan; Guoliang Liu; Thomas E Wiese; Ellen Glotser; Hua Mei Journal: ACS Omega Date: 2022-06-24
Authors: Neha Tiwari; Ernesto Rafael Osorio-Blanco; Ana Sonzogni; David Esporrín-Ubieto; Huiyi Wang; Marcelo Calderón Journal: Angew Chem Int Ed Engl Date: 2021-10-01 Impact factor: 16.823
Authors: Abraham J P Teunissen; Marianne E Burnett; Geoffrey Prévot; Emma D Klein; Daniel Bivona; Willem J M Mulder Journal: Wiley Interdiscip Rev Nanomed Nanobiotechnol Date: 2021-04-13
Authors: Peter J Altshuler; Alexis R Schiazza; Lijun Luo; Mark R Helmers; Bonirath Chhay; Jason J Han; Robin Hu; D Alan Herbst; Andrew Tsourkas; Zhiliang Cheng; Pavan Atluri Journal: Adv Ther (Weinh) Date: 2021-04-23