Literature DB >> 32243803

Plasticity in Motion: Shape-Shifting Lgr5-Cells Initiate Colorectal Cancer Metastasis.

Karuna Ganesh1.   

Abstract

In this issue of Cell Stem Cell, Fumagalli et al. (2020) employ intravital microscopy of colorectal cancer organoid xenografts to investigate the cell of origin of metastases. While tumor-initiating cells are Lgr5+, most disseminated cancer cells are Lgr5- and seed liver metastases in which Lgr5+ cells then appear, showing that bidirectional plasticity of phenotypic states drives metastasis.
Copyright © 2020 Elsevier Inc. All rights reserved.

Entities:  

Year:  2020        PMID： 32243803      PMCID： PMC7295070          DOI： 10.1016/j.stem.2020.03.007

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  9 in total

Review 1.  Cellular Plasticity in Intestinal Homeostasis and Disease.

Authors:  Felipe de Sousa E Melo; Frederic J de Sauvage
Journal:  Cell Stem Cell       Date:  2018-12-27       Impact factor: 24.633

Review 2.  Stem cells, cancer, and cancer stem cells.

Authors:  T Reya; S J Morrison; M F Clarke; I L Weissman
Journal:  Nature       Date:  2001-11-01       Impact factor: 49.962

3.  A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer.

Authors:  Felipe de Sousa e Melo; Antonina V Kurtova; Jonathan M Harnoss; Noelyn Kljavin; Joerg D Hoeck; Jeffrey Hung; Jeffrey Eastham Anderson; Elaine E Storm; Zora Modrusan; Hartmut Koeppen; Gerrit J P Dijkgraaf; Robert Piskol; Frederic J de Sauvage
Journal:  Nature       Date:  2017-03-29       Impact factor: 49.962

Review 4.  EMT, CSCs, and drug resistance: the mechanistic link and clinical implications.

Authors:  Tsukasa Shibue; Robert A Weinberg
Journal:  Nat Rev Clin Oncol       Date:  2017-04-11       Impact factor: 66.675

5.  Crypt stem cells as the cells-of-origin of intestinal cancer.

Authors:  Nick Barker; Rachel A Ridgway; Johan H van Es; Marc van de Wetering; Harry Begthel; Maaike van den Born; Esther Danenberg; Alan R Clarke; Owen J Sansom; Hans Clevers
Journal:  Nature       Date:  2008-12-17       Impact factor: 49.962

6.  Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells.

Authors:  Kazutaka Murata; Unmesh Jadhav; Shariq Madha; Johan van Es; Justin Dean; Alessia Cavazza; Kai Wucherpfennig; Franziska Michor; Hans Clevers; Ramesh A Shivdasani
Journal:  Cell Stem Cell       Date:  2020-02-20       Impact factor: 24.633

7.  Identification of stem cells in small intestine and colon by marker gene Lgr5.

Authors:  Nick Barker; Johan H van Es; Jeroen Kuipers; Pekka Kujala; Maaike van den Born; Miranda Cozijnsen; Andrea Haegebarth; Jeroen Korving; Harry Begthel; Peter J Peters; Hans Clevers
Journal:  Nature       Date:  2007-10-14       Impact factor: 49.962

8.  Specific Labeling of Stem Cell Activity in Human Colorectal Organoids Using an ASCL2-Responsive Minigene.

Authors:  Koen C Oost; Lisa van Voorthuijsen; Arianna Fumagalli; Rik G H Lindeboom; Joep Sprangers; Manja Omerzu; Maria J Rodriguez-Colman; Maria C Heinz; Ingrid Verlaan-Klink; Madelon M Maurice; Boudewijn M T Burgering; Jacco van Rheenen; Michiel Vermeulen; Hugo J G Snippert
Journal:  Cell Rep       Date:  2018-02-06       Impact factor: 9.423

9.  Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer.

Authors:  Arianna Fumagalli; Koen C Oost; Lennart Kester; Jessica Morgner; Laura Bornes; Lotte Bruens; Lisa Spaargaren; Maria Azkanaz; Tim Schelfhorst; Evelyne Beerling; Maria C Heinz; Daniel Postrach; Danielle Seinstra; Anieta M Sieuwerts; John W M Martens; Stefan van der Elst; Martijn van Baalen; Debajit Bhowmick; Nienke Vrisekoop; Saskia I J Ellenbroek; Saskia J E Suijkerbuijk; Hugo J Snippert; Jacco van Rheenen
Journal:  Cell Stem Cell       Date:  2020-03-12       Impact factor: 24.633
  9 in total
  2 in total

1.  Colorectal Cancer Stem Cell States Uncovered by Simultaneous Single-Cell Analysis of Transcriptome and Telomeres.

Authors:  Hua Wang; Peng Gong; Tong Chen; Shan Gao; Zhenfeng Wu; Xiaodong Wang; Jie Li; Sadie L Marjani; José Costa; Sherman M Weissman; Feng Qi; Xinghua Pan; Lin Liu
Journal:  Adv Sci (Weinh)       Date:  2021-02-08       Impact factor: 16.806

2.  Tumor-suppressive function of EZH2 is through inhibiting glutaminase.

Authors:  Yongfeng Liu; Cheng-E Tu; Xuxue Guo; Changjie Wu; Chuncai Gu; Qiuhua Lai; Yuxin Fang; Junqi Huang; Zhizhang Wang; Aimin Li; Side Liu
Journal:  Cell Death Dis       Date:  2021-10-20       Impact factor: 8.469
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.