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Literature DB >> 32243797

Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases.

Lars Fugger¹, Lise Torp Jensen², Jamie Rossjohn³.

Abstract

Autoimmune diseases are a result of the immune system being misdirected toward its host and have major and increasing unmet clinical needs. In general, present therapies are broadly acting and non-disease specific; consequently, they are associated with numerous side effects. Precise and early intervention strategies are urgently needed. We highlight the challenges, progress, and prospects in achieving these goals.

Entities: Chemical

Mesh：

Substances：
Immunosuppressive Agents

Year: 2020 PMID： 32243797 DOI： 10.1016/j.cell.2020.03.007

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

Keyword Cloud
Cited

30 in total

1. A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response.

Authors: Roeland Lameris; Adam Shahine; Daniel G Pellicci; Adam P Uldrich; Stephanie Gras; Jérôme Le Nours; Richard W J Groen; Jana Vree; Scott J J Reddiex; Sergio M Quiñones-Parra; Stewart K Richardson; Amy R Howell; Sonja Zweegman; Dale I Godfrey; Tanja D de Gruijl; Jamie Rossjohn; Hans J van der Vliet
Journal: Nat Cancer Date: 2020-09-14

2. Apoptotic body-inspired nanoparticles target macrophages at sites of inflammation to support an anti-inflammatory phenotype shift.

Authors: Chelsea A Kraynak; Wenbai Huang; Elizabeth C Bender; Jie-Liang Wang; Mahmoud S Hanafy; Zhengrong Cui; Laura J Suggs
Journal: Int J Pharm Date: 2022-03-03 Impact factor: 5.875

Review 3. Microbiota-assisted therapy for systemic inflammatory arthritis: advances and mechanistic insights.

Authors: Bowen Li; Bo Yang; Xiaoming Liu; Jianxin Zhao; R Paul Ross; Catherine Stanton; Hao Zhang; Wei Chen
Journal: Cell Mol Life Sci Date: 2022-08-06 Impact factor: 9.207

Review 4. An Update on the Evolutionary History of Bregs.

Authors: Michel-Edwar Mickael; Irmina Bieńkowska; Mariusz Sacharczuk
Journal: Genes (Basel) Date: 2022-05-17 Impact factor: 4.141

5. Selective activation and expansion of regulatory T cells using lipid encapsulated mRNA encoding a long-acting IL-2 mutein.

Authors: Seymour de Picciotto; Nicholas DeVita; Chiaowen Joyce Hsiao; Christopher Honan; Sze-Wah Tse; Mychael Nguyen; Joseph D Ferrari; Wei Zheng; Brian T Wipke; Eric Huang
Journal: Nat Commun Date: 2022-07-05 Impact factor: 17.694

Review 10. Possible implications of dysregulated nicotinic acetylcholine receptor diffusion and nanocluster formation in myasthenia gravis.

Authors: Francisco J Barrantes
Journal: Neural Regen Res Date: 2021-02 Impact factor: 5.135

Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases.

1. A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response.

2. Apoptotic body-inspired nanoparticles target macrophages at sites of inflammation to support an anti-inflammatory phenotype shift.

Review 3. Microbiota-assisted therapy for systemic inflammatory arthritis: advances and mechanistic insights.

Review 4. An Update on the Evolutionary History of Bregs.

5. Selective activation and expansion of regulatory T cells using lipid encapsulated mRNA encoding a long-acting IL-2 mutein.

6. Systematic Review of Safety and Efficacy of IL-1-Targeted Biologics in Treating Immune-Mediated Disorders.

Review 7. Activation pathways that drive CD4⁺ T cells to break tolerance in autoimmune diseases^.

Review 8. Leveraging diet to engineer the gut microbiome.

9. Risk of Herpes Zoster Among Psoriasis Patients Taking Biologics: A Network Meta-Analysis of Cohort Studies.

Review 10. Possible implications of dysregulated nicotinic acetylcholine receptor diffusion and nanocluster formation in myasthenia gravis.

Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases.

1. A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response.

2. Apoptotic body-inspired nanoparticles target macrophages at sites of inflammation to support an anti-inflammatory phenotype shift.

Review 3. Microbiota-assisted therapy for systemic inflammatory arthritis: advances and mechanistic insights.

Review 4. An Update on the Evolutionary History of Bregs.

5. Selective activation and expansion of regulatory T cells using lipid encapsulated mRNA encoding a long-acting IL-2 mutein.

6. Systematic Review of Safety and Efficacy of IL-1-Targeted Biologics in Treating Immune-Mediated Disorders.

Review 7. Activation pathways that drive CD4+ T cells to break tolerance in autoimmune diseases.

Review 8. Leveraging diet to engineer the gut microbiome.

9. Risk of Herpes Zoster Among Psoriasis Patients Taking Biologics: A Network Meta-Analysis of Cohort Studies.

Review 10. Possible implications of dysregulated nicotinic acetylcholine receptor diffusion and nanocluster formation in myasthenia gravis.

Review 7. Activation pathways that drive CD4⁺ T cells to break tolerance in autoimmune diseases^.