Comparison of the proteolytic specificities of bovine and porcine pepsin A.

Bovine pepsin A inactivates pancreatic ribonuclease through a limited proteolysis the same way as does porcine pepsin A. The specific activity is lower and more dependent on the ionic strength. The proteolytic specificity of bovine pepsin A has been investigated with B-chain of oxidized porcine insulin as the substrate. The specificity resembles qualitatively that of porcine pepsin but with quantitative differences.