Ziwen Deng1, Lu Zhang2, Qian Tang2, Yinglei Xu2, Shiguo Liu3, Hui Li4. 1. Department of Clinical Laboratory, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China. 2. Medical Genetic Department, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China; Prenatal Diagnosis Centre, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China. 3. Medical Genetic Department, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China; Prenatal Diagnosis Centre, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China. Electronic address: liushiguo2002@126.com. 4. Department of Clinical Laboratory, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China. Electronic address: lh99007@163.com.
Abstract
OBJECTIVE: Pre-eclampsia (PE) is a common multi-systemic disease, and the effect of cytokines on PE is not clear. The purpose of this meta-analysis was to evaluate the circulating levels of interferon gamma (IFN-γ), interleukin (IL)-1, IL-17 and IL-22 in patients with PE. STUDY DESIGN: Relevant studies were identified after a preliminary investigation of studies published up to May 2019 using PubMed and Embase. In this study, all 27 included articles underwent quality rating, with a total of 495 patients with PE and 557 controls. Among them, eight papers and 932 subjects contributed to the meta-analysis of IFN-γ, and six papers and 343 subjects contributed to the meta-analysis of IL-17. Based on the inclusion and exclusion criteria, the retrieved papers were screened and evaluated independently. Relevant data for IFN-γ and IL-17 were extracted for meta-analysis and subgroup analysis, and the stability of the results was evaluated by sensitivity analysis. At the same time, a systematic evaluation was carried out for IL-1 and IL-22 with a small number of included papers. RESULTS: Several papers included in the systematic review showed that the circulating levels of IL-22 were higher in patients with severe PE than in controls, while IL-1 levels did not differ significantly between the two groups. The meta-analysis showed that patients with PE had higher circulating levels of IFN-γ than controls [standardized mean difference (SMD) 1.45, 95 % confidence interval (CI) 0.56-2.34]. There was no evidence of a difference in the circulating levels of IL-17 between patients with PE and controls (SMD 0.53, 95 %CI -0.43 to 1.48). CONCLUSION: This meta-analysis suggested that changes in circulating levels of IFN-γ might be associated with PE.
OBJECTIVE: Pre-eclampsia (PE) is a common multi-systemic disease, and the effect of cytokines on PE is not clear. The purpose of this meta-analysis was to evaluate the circulating levels of interferon gamma (IFN-γ), interleukin (IL)-1, IL-17 and IL-22 in patients with PE. STUDY DESIGN: Relevant studies were identified after a preliminary investigation of studies published up to May 2019 using PubMed and Embase. In this study, all 27 included articles underwent quality rating, with a total of 495 patients with PE and 557 controls. Among them, eight papers and 932 subjects contributed to the meta-analysis of IFN-γ, and six papers and 343 subjects contributed to the meta-analysis of IL-17. Based on the inclusion and exclusion criteria, the retrieved papers were screened and evaluated independently. Relevant data for IFN-γ and IL-17 were extracted for meta-analysis and subgroup analysis, and the stability of the results was evaluated by sensitivity analysis. At the same time, a systematic evaluation was carried out for IL-1 and IL-22 with a small number of included papers. RESULTS: Several papers included in the systematic review showed that the circulating levels of IL-22 were higher in patients with severe PE than in controls, while IL-1 levels did not differ significantly between the two groups. The meta-analysis showed that patients with PE had higher circulating levels of IFN-γ than controls [standardized mean difference (SMD) 1.45, 95 % confidence interval (CI) 0.56-2.34]. There was no evidence of a difference in the circulating levels of IL-17 between patients with PE and controls (SMD 0.53, 95 %CI -0.43 to 1.48). CONCLUSION: This meta-analysis suggested that changes in circulating levels of IFN-γ might be associated with PE.
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Authors: Sarah Meister; Laura Hahn; Susanne Beyer; Corinna Paul; Sophie Mitter; Christina Kuhn; Viktoria von Schönfeldt; Stefanie Corradini; Kritika Sudan; Christian Schulz; Theresa Maria Kolben; Sven Mahner; Udo Jeschke; Thomas Kolben Journal: Int J Mol Sci Date: 2021-11-18 Impact factor: 5.923
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