Literature DB >> 32240524

Endogenous Regulatory T Cells Promote M2 Macrophage Phenotype in Diabetic Stroke as Visualized by Optical Imaging.

Yu Cai1, Ting-Ting Xu1, Chun-Qiang Lu1, Yuan-Yuan Ma1, Di Chang1, Yi Zhang1, Xiao-Chun Gu1, Shenghong Ju2.   

Abstract

Regulatory T cells (Tregs) play an immunosuppressive role in various diseases, yet their function remains controversial in stroke and obscure in diabetic stroke. In the present study, Tregs were found downregulated in the peripheral blood of type 2 diabetes mellitus (T2DM) stroke models and patients compared with controls. In ischemic stroke mice (both T2DM and wild type), endogenous Tregs boosted by CD28SA increased CD206+ M2 macrophage/microglia cells, decreased infarct volumes, and improved neurological recovery. Our results demonstrated the potential of boosting Tregs for treating T2DM stroke. Furthermore, we utilized an optical imaging probe (IRD-αCD206) to target M2 macrophage/microglia cells and demonstrated its effect in visualizing M2 macrophage/microglia cells in vivo in ischemic brain tissue.

Entities:  

Keywords:  Ischemic stroke; M2 macrophages/microglia; Optical imaging; Regulatory T cells; Type 2 diabetes mellitus

Year:  2020        PMID： 32240524     DOI： 10.1007/s12975-020-00808-x

Source DB:  PubMed          Journal:  Transl Stroke Res        ISSN： 1868-4483            Impact factor:   6.829


  29 in total

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Review 3.  Type 2 diabetes as an inflammatory disease.

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Journal:  Diabetes       Date:  2014-05-08       Impact factor: 9.461

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5.  CD4+CD25+ Regulatory T Cells in Intracranial Thrombi Are Inversely Correlated with Hemorrhagic Transformation after Thrombectomy: A Clinical-Immunohistochemical Analysis of Acute Ischemic Stroke.

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  8 in total

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