The research and development process for multiscale models of infectious disease systems.

Multiscale modelling of infectious disease systems falls within the domain of complexity science-the study of complex systems. However, what should be made clear is that current progress in multiscale modelling of infectious disease dynamics is still as yet insufficient to present it as a mature sub-discipline of complexity science. In this article we present a methodology for development of multiscale models of infectious disease systems. This methodology is a set of partially ordered research and development activities that result in multiscale models of infectious disease systems built from different scientific approaches. Therefore, the conclusive result of this article is a methodology to design multiscale models of infectious diseases. Although this research and development process for multiscale models cannot be claimed to be unique and final, it constitutes a good starting point, which may be found useful as a basis for further refinement in the discourse for multiscale modelling of infectious disease dynamics.