Yafei Zhang1,2, Liang Zheng3, Lan Liu1,2, Mengya Zhao4, Jun Xiao1,2, Qiu Zhao1,2. 1. Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China. 2. Clinical Center and Key Lab of Intestinal and Colorectal Diseases of Hubei Province, Wuhan, China. 3. Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. 4. Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Abstract
BACKGROUND: The SARS-CoV-2 pandemic is an ongoing global health emergency. The aim of our study was to investigate the changes of liver function and its clinical significance in COVID-19 patients. METHOD: This retrospective, single-centre study was conducted on 115 confirmed cases of COVID-19 in Zhongnan hospital of Wuhan University from 18 January 2020 to 22 February 2020. Liver function and related indexes were analysed to evaluate its relationship with disease progression in COVID-19 patients. RESULTS: Part of the COVID-19 patients presented with varying degrees of abnormality in liver function indexes. However, the levels of ALT, AST, TBIL, GGT and LDH in COVID-19 patients were not significantly different when compared with hospitalised community-acquired pneumonia patients, and the levels of albumin is even significantly higher. The levels of ALT, AST, TBIL, LDH and INR showed statistically significant elevation in severe COVID-19 cases compared with that in mild cases. However, the clinical significance of the elevation is unremarkable. Majority of severe COVID-19 patients showed significantly decreasing in albumin level and continuously decreasing in the progress of illness. Most of the liver function indexes in COVID-19 patients were correlated with CRP and NLR, the markers of inflammation. Logistic regression analysis further identified NLR as the independent risk factor for severe COVID-19, as well as age. CONCLUSIONS: Although abnormalities of liver function indexes are common in COVID-19 patients, the impairment of liver function is not a prominent feature of COVID-19, and also may not have serious clinical consequences.
BACKGROUND: The SARS-CoV-2 pandemic is an ongoing global health emergency. The aim of our study was to investigate the changes of liver function and its clinical significance in COVID-19patients. METHOD: This retrospective, single-centre study was conducted on 115 confirmed cases of COVID-19 in Zhongnan hospital of Wuhan University from 18 January 2020 to 22 February 2020. Liver function and related indexes were analysed to evaluate its relationship with disease progression in COVID-19patients. RESULTS: Part of the COVID-19patients presented with varying degrees of abnormality in liver function indexes. However, the levels of ALT, AST, TBIL, GGT and LDH in COVID-19patients were not significantly different when compared with hospitalised community-acquired pneumoniapatients, and the levels of albumin is even significantly higher. The levels of ALT, AST, TBIL, LDH and INR showed statistically significant elevation in severe COVID-19 cases compared with that in mild cases. However, the clinical significance of the elevation is unremarkable. Majority of severe COVID-19patients showed significantly decreasing in albumin level and continuously decreasing in the progress of illness. Most of the liver function indexes in COVID-19patients were correlated with CRP and NLR, the markers of inflammation. Logistic regression analysis further identified NLR as the independent risk factor for severe COVID-19, as well as age. CONCLUSIONS: Although abnormalities of liver function indexes are common in COVID-19patients, the impairment of liver function is not a prominent feature of COVID-19, and also may not have serious clinical consequences.
Authors: Sami A Chadi; Keegan Guidolin; Antonio Caycedo-Marulanda; Abdu Sharkawy; Antonino Spinelli; Fayez A Quereshy; Allan Okrainec Journal: Ann Surg Date: 2020-05-20 Impact factor: 12.969
Authors: Vilson Sovio Oliveira de Macedo; Geterson Bezerra Moreira; Ana Cristina Fiuza de Albuquerque; Sebastião Carlos de Sousa Oliveira; Mateus Aragão Esmeraldo; Francisco Cesar Barroso Barbosa Journal: J Vasc Bras Date: 2021-03-15