Literature DB >> 32239474

Structure and function of the co-chaperone protein phosphatase 5 in cancer.

Rebecca A Sager1,2,3,4, Natela Dushukyan1,2,3, Mark Woodford1,2,3, Mehdi Mollapour5,6,7.   

Abstract

Protein phosphatase 5 (PP5) is a serine/threonine protein phosphatase that regulates many cellular functions including steroid hormone signaling, stress response, proliferation, apoptosis, and DNA repair. PP5 is also a co-chaperone of the heat shock protein 90 molecular chaperone machinery that assists in regulation of cellular signaling pathways essential for cell survival and growth. PP5 plays a significant role in survival and propagation of multiple cancers, which makes it a promising target for cancer therapy. Though there are several naturally occurring PP5 inhibitors, none is specific for PP5. Here, we review the roles of PP5 in cancer progression and survival and discuss the unique features of the PP5 structure that differentiate it from other phosphoprotein phosphatase (PPP) family members and make it an attractive therapeutic target.

Entities:  

Keywords:  Cancer; Clear cell renal cell carcinoma; Co-chaperone; Heat shock protein 90; Molecular chaperone; Post-translational modifications; Serine/threonine phosphatase 5

Mesh：

Substances：

Year:  2020        PMID： 32239474      PMCID： PMC7193036          DOI： 10.1007/s12192-020-01091-3

Source DB:  PubMed          Journal:  Cell Stress Chaperones        ISSN： 1355-8145            Impact factor:   3.667


  93 in total

1.  Rac GTPase signaling through the PP5 protein phosphatase.

Authors:  Saverio Gentile; Thomas Darden; Christian Erxleben; Charles Romeo; Angela Russo; Negin Martin; Sandra Rossie; David L Armstrong
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-20       Impact factor: 11.205

2.  The Antitumor Drug LB-100 Is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Active-Site Catalytic Metals in PPP5C.

Authors:  Brandon M D'Arcy; Mark R Swingle; Cinta M Papke; Kevin A Abney; Erin S Bouska; Aishwarya Prakash; Richard E Honkanen
Journal:  Mol Cancer Ther       Date:  2019-01-24       Impact factor: 6.261

3.  Phosphorylation and Ubiquitination Regulate Protein Phosphatase 5 Activity and Its Prosurvival Role in Kidney Cancer.

Authors:  Natela Dushukyan; Diana M Dunn; Rebecca A Sager; Mark R Woodford; David R Loiselle; Michael Daneshvar; Alexander J Baker-Williams; John D Chisholm; Andrew W Truman; Cara K Vaughan; Timothy A Haystead; Gennady Bratslavsky; Dimitra Bourboulia; Mehdi Mollapour
Journal:  Cell Rep       Date:  2017-11-14       Impact factor: 9.423

4.  Serine/threonine protein phosphatase type 5 acts upstream of p53 to regulate the induction of p21(WAF1/Cip1) and mediate growth arrest.

Authors:  Z Zuo; N M Dean; R E Honkanen
Journal:  J Biol Chem       Date:  1998-05-15       Impact factor: 5.157

5.  S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation.

Authors:  Fuminori Yamaguchi; Yoshinori Umeda; Seiko Shimamoto; Mitsumasa Tsuchiya; Hiroshi Tokumitsu; Masaaki Tokuda; Ryoji Kobayashi
Journal:  J Biol Chem       Date:  2012-03-07       Impact factor: 5.157

6.  Evidence that protein phosphatase 5 functions to negatively modulate the maturation of the Hsp90-dependent heme-regulated eIF2alpha kinase.

Authors:  Jieya Shao; Steven D Hartson; Robert L Matts
Journal:  Biochemistry       Date:  2002-05-28       Impact factor: 3.162

7.  Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer.

Authors:  Teresa Golden; Ileana V Aragon; Beth Rutland; J Allan Tucker; Lalita A Shevde; Rajeev S Samant; Guofei Zhou; Lauren Amable; Danalea Skarra; Richard E Honkanen
Journal:  Biochim Biophys Acta       Date:  2008-01-26

8.  Inhibition of protein phosphatase 5 suppresses non-small cell lung cancer through AMP-activated kinase activation.

Authors:  Feng-Shu Hsieh; Man-Hsin Hung; Cheng-Yi Wang; Yen-Lin Chen; Yung-Jen Hsiao; Ming-Hsien Tsai; Jia-Rong Li; Li-Ju Chen; Chih-Ting Shih; Tzu-I Chao; Kuen-Feng Chen
Journal:  Lung Cancer       Date:  2017-08-05       Impact factor: 5.705

9.  Palbociclib enhances radiosensitivity of hepatocellular carcinoma and cholangiocarcinoma via inhibiting ataxia telangiectasia-mutated kinase-mediated DNA damage response.

Authors:  Chao-Yuan Huang; Feng-Shu Hsieh; Cheng-Yi Wang; Li-Ju Chen; Shih-Shin Chang; Ming-Hsien Tsai; Man-Hsin Hung; Chiung-Wen Kuo; Chi-Ting Shih; Tzu-I Chao; Kuen-Feng Chen
Journal:  Eur J Cancer       Date:  2018-08-10       Impact factor: 9.162

10.  Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes.

Authors:  Judith Krysiak; Andreas Unger; Lisa Beckendorf; Nazha Hamdani; Marion von Frieling-Salewsky; Margaret M Redfield; Cris G Dos Remedios; Farah Sheikh; Ulrich Gergs; Peter Boknik; Wolfgang A Linke
Journal:  Nat Commun       Date:  2018-01-17       Impact factor: 14.919
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  2 in total

Review 1.  Therapeutic potential of CDK4/6 inhibitors in renal cell carcinoma.

Authors:  Rebecca A Sager; Sarah J Backe; Elham Ahanin; Garrett Smith; Imad Nsouli; Mark R Woodford; Gennady Bratslavsky; Dimitra Bourboulia; Mehdi Mollapour
Journal:  Nat Rev Urol       Date:  2022-03-09       Impact factor: 16.430

Review 2.  Emerging Link between Tsc1 and FNIP Co-Chaperones of Hsp90 and Cancer.

Authors:  Sarah J Backe; Rebecca A Sager; Katherine A Meluni; Mark R Woodford; Dimitra Bourboulia; Mehdi Mollapour
Journal:  Biomolecules       Date:  2022-07-01
  2 in total

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