The silver catalyzed direct C-H functionalization of quinones with dialkyl amides.

DMA and other dialkylamides were successfully used as synthons for the C-H functionalization of quinones. This novel amidoalkylation reaction works with a variety of substituted quinones and dialkyl/alkyl amides, such as DMF, NMP and NMA, and the corresponding products were obtained in moderate to good yields. The amidoalkylation of quinones is demonstrated for the first time. A suitable mechanism and the synthetic utility of these compounds are demonstrated. The molecular docking of compound 5 with an Alzheimer's disease (AD) associated AChE target site was studied.