Literature DB >> 32238557

Squalene and cholesterol in the balance at the ER membrane.

James A Nathan1.   

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Year:  2020        PMID： 32238557      PMCID： PMC7165475          DOI： 10.1073/pnas.2003388117

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


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  22 in total

1.  A general amphipathic alpha-helical motif for sensing membrane curvature.

Authors:  Guillaume Drin; Jean-François Casella; Romain Gautier; Thomas Boehmer; Thomas U Schwartz; Bruno Antonny
Journal:  Nat Struct Mol Biol       Date:  2007-01-14       Impact factor: 15.369

Review 2.  The antifungal pipeline: a reality check.

Authors:  John R Perfect
Journal:  Nat Rev Drug Discov       Date:  2017-05-12       Impact factor: 84.694

Review 3.  A century of cholesterol and coronaries: from plaques to genes to statins.

Authors:  Joseph L Goldstein; Michael S Brown
Journal:  Cell       Date:  2015-03-26       Impact factor: 41.582

4.  The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway.

Authors:  Noam Zelcer; Laura J Sharpe; Anke Loregger; Ika Kristiana; Emma C L Cook; Lisa Phan; Julian Stevenson; Andrew J Brown
Journal:  Mol Cell Biol       Date:  2014-01-21       Impact factor: 4.272

5.  The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change.

Authors:  Vicky Howe; Ngee Kiat Chua; Julian Stevenson; Andrew J Brown
Journal:  J Biol Chem       Date:  2015-10-03       Impact factor: 5.157

6.  A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis.

Authors:  Ngee Kiat Chua; Vicky Howe; Nidhi Jatana; Lipi Thukral; Andrew J Brown
Journal:  J Biol Chem       Date:  2017-09-27       Impact factor: 5.157

7.  Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis.

Authors:  Akash Das; Michael S Brown; Donald D Anderson; Joseph L Goldstein; Arun Radhakrishnan
Journal:  Elife       Date:  2014-06-11       Impact factor: 8.140

8.  Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3.

Authors:  Stefan Schoebel; Wei Mi; Alexander Stein; Sergey Ovchinnikov; Ryan Pavlovicz; Frank DiMaio; David Baker; Melissa G Chambers; Huayou Su; Dongsheng Li; Tom A Rapoport; Maofu Liao
Journal:  Nature       Date:  2017-07-06       Impact factor: 49.962

9.  Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death.

Authors:  Javier Garcia-Bermudez; Lou Baudrier; Erol Can Bayraktar; Yihui Shen; Konnor La; Rohiverth Guarecuco; Burcu Yucel; Danilo Fiore; Bernardo Tavora; Elizaveta Freinkman; Sze Ham Chan; Caroline Lewis; Wei Min; Giorgio Inghirami; David M Sabatini; Kıvanç Birsoy
Journal:  Nature       Date:  2019-02-13       Impact factor: 49.962

10.  A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate.

Authors:  Hiromasa Yoshioka; Hudson W Coates; Ngee Kiat Chua; Yuichi Hashimoto; Andrew J Brown; Kenji Ohgane
Journal:  Proc Natl Acad Sci U S A       Date:  2020-03-13       Impact factor: 11.205
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  2 in total

1.  Targeting Squalene Epoxidase Interrupts Homologous Recombination via the ER Stress Response and Promotes Radiotherapy Efficacy.

Authors:  Zhipeng Hong; Tao Liu; Lingfeng Wan; Pengyan Fa; Pankaj Kumar; Yanan Cao; Chandra Bhushan Prasad; Zhaojun Qiu; Joseph Liu; Hongbing Wang; Zaibo Li; Qi-En Wang; Peixuan Guo; Deliang Guo; Ayse S Yilmaz; Lanchun Lu; Ioanna Papandreou; Naduparambil K Jacob; Chunhong Yan; Xiaoli Zhang; Qing-Bai She; Zhefu Ma; Junran Zhang
Journal:  Cancer Res       Date:  2022-04-01       Impact factor: 13.312

Review 2.  Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy.

Authors:  Yuheng Zou; Hongying Zhang; Feng Bi; Qiulin Tang; Huanji Xu
Journal:  Front Oncol       Date:  2022-08-24       Impact factor: 5.738
  2 in total

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