Rethinking biorational insecticides for pest management: unintended effects and consequences.

Biorational insecticides are composed of natural products, including animals, plants, microbes, and minerals, or are their derivates. The use of biorational products for the management of insect pests has grown intensively in recent years, which has increased their popularity and share on the insecticide global market. Much of these recent increases in the use of biorational insecticides has been derived from the generalized perception that conventional insecticides have undesirable ecological and human health impacts. However, the idea of simply replacing synthetic compounds with biorational insecticides without considering their potential unintended effects can mislead their use and reduce the market life of such pest management tools. A systematic literature survey encompassing over 15 000 scientific manuscripts published between 1945 and 2019 reinforces the bias of focusing on studying the targeted effects while overlooking the potential detrimental effects of biorational products on human health and the environment (e.g. death and negative sublethal effects on pollinators and beneficial arthropods such as parasitoids and predators). Thus, the risks associated with biorational compounds (e.g. control failures, the evolution of resistance, shift in dominance, and outbreaks of secondary or primary pests) need to be revisited and the outcomes of such inquiry could be decisive for their future use in pest management programs. The shortcomings of regulatory processes, knowledge gaps, and the outlook for the use of the biorational products in pest management are discussed.