Literature DB >> 32236961

Blocking the road to de-differentiation: HNF1A/KDM6A complex safeguards epithelial integrity in pancreatic cancer.

Stefanie Bärthel1,2,3, Günter Schneider2,4, Dieter Saur1,2,3,4.   

Abstract

Epithelial differentiation of normal and tumor cells is orchestrated by lineage-determining transcriptional regulatory networks that enforce cell identity. Recent research by Kalisz et al (2020) in the EMBO Journal elucidates the molecular mechanisms by which a transcriptional differentiation program governed by HNF1A and KDM6A maintains acinar differentiation and the epithelial identity of pancreatic ductal adenocarcinoma (PDAC). Loss of function of either transcriptional regulator induces tumor progression to a poorly differentiated and highly aggressive PDAC subtype with a squamous transcriptome and poor prognosis.
© 2020 The Authors.

Entities:  

Mesh：

Substances：

Year:  2020        PMID： 32236961      PMCID： PMC7196913          DOI： 10.15252/embj.2020104759

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  11 in total

Review 1.  Molecular subtypes of pancreatic cancer.

Authors:  Eric A Collisson; Peter Bailey; David K Chang; Andrew V Biankin
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2019-04       Impact factor: 46.802

2.  FOXA2 controls the cis-regulatory networks of pancreatic cancer cells in a differentiation grade-specific manner.

Authors:  Marta Milan; Chiara Balestrieri; Gabriele Alfarano; Sara Polletti; Elena Prosperini; Paola Spaggiari; Alessandro Zerbi; Giuseppe R Diaferia; Gioacchino Natoli
Journal:  EMBO J       Date:  2019-09-17       Impact factor: 11.598

3.  Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution.

Authors:  Michelle Chan-Seng-Yue; Jaeseung C Kim; Gavin W Wilson; Karen Ng; Eugenia Flores Figueroa; Grainne M O'Kane; Ashton A Connor; Robert E Denroche; Robert C Grant; Jessica McLeod; Julie M Wilson; Gun Ho Jang; Amy Zhang; Anna Dodd; Sheng-Ben Liang; Ayelet Borgida; Dianne Chadwick; Sangeetha Kalimuthu; Ilinca Lungu; John M S Bartlett; Paul M Krzyzanowski; Vandana Sandhu; Hervé Tiriac; Fieke E M Froeling; Joanna M Karasinska; James T Topham; Daniel J Renouf; David F Schaeffer; Steven J M Jones; Marco A Marra; Janessa Laskin; Runjan Chetty; Lincoln D Stein; George Zogopoulos; Benjamin Haibe-Kains; Peter J Campbell; David A Tuveson; Jennifer J Knox; Sandra E Fischer; Steven Gallinger; Faiyaz Notta
Journal:  Nat Genet       Date:  2020-01-13       Impact factor: 38.330

4.  Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial.

Authors:  Kyaw L Aung; Sandra E Fischer; Robert E Denroche; Gun-Ho Jang; Anna Dodd; Sean Creighton; Bernadette Southwood; Sheng-Ben Liang; Dianne Chadwick; Amy Zhang; Grainne M O'Kane; Hamzeh Albaba; Shari Moura; Robert C Grant; Jessica K Miller; Faridah Mbabaali; Danielle Pasternack; Ilinca M Lungu; John M S Bartlett; Sangeet Ghai; Mathieu Lemire; Spring Holter; Ashton A Connor; Richard A Moffitt; Jen Jen Yeh; Lee Timms; Paul M Krzyzanowski; Neesha Dhani; David Hedley; Faiyaz Notta; Julie M Wilson; Malcolm J Moore; Steven Gallinger; Jennifer J Knox
Journal:  Clin Cancer Res       Date:  2017-12-29       Impact factor: 12.531

5.  Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors.

Authors:  Jaclyn Andricovich; Stephanie Perkail; Yan Kai; Nicole Casasanta; Weiqun Peng; Alexandros Tzatsos
Journal:  Cancer Cell       Date:  2018-03-12       Impact factor: 31.743

6.  Adipocyte extracellular vesicles carry enzymes and fatty acids that stimulate mitochondrial metabolism and remodeling in tumor cells.

Authors:  Emily Clement; Ikrame Lazar; Camille Attané; Lorry Carrié; Stéphanie Dauvillier; Manuelle Ducoux-Petit; David Esteve; Thomas Menneteau; Mohamed Moutahir; Sophie Le Gonidec; Stéphane Dalle; Philippe Valet; Odile Burlet-Schiltz; Catherine Muller; Laurence Nieto
Journal:  EMBO J       Date:  2020-01-10       Impact factor: 11.598

Review 7.  Regulation of Cellular Identity in Cancer.

Authors:  Nilotpal Roy; Matthias Hebrok
Journal:  Dev Cell       Date:  2015-12-21       Impact factor: 12.270

8.  Dissection of transcriptional and cis-regulatory control of differentiation in human pancreatic cancer.

Authors:  Giuseppe R Diaferia; Chiara Balestrieri; Elena Prosperini; Paola Nicoli; Paola Spaggiari; Alessandro Zerbi; Gioacchino Natoli
Journal:  EMBO J       Date:  2016-01-14       Impact factor: 11.598

9.  Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes.

Authors:  Sebastian Mueller; Thomas Engleitner; Roman Maresch; Magdalena Zukowska; Sebastian Lange; Thorsten Kaltenbacher; Björn Konukiewitz; Rupert Öllinger; Maximilian Zwiebel; Alex Strong; Hsi-Yu Yen; Ruby Banerjee; Sandra Louzada; Beiyuan Fu; Barbara Seidler; Juliana Götzfried; Kathleen Schuck; Zonera Hassan; Andreas Arbeiter; Nina Schönhuber; Sabine Klein; Christian Veltkamp; Mathias Friedrich; Lena Rad; Maxim Barenboim; Christoph Ziegenhain; Julia Hess; Oliver M Dovey; Stefan Eser; Swati Parekh; Fernando Constantino-Casas; Jorge de la Rosa; Marta I Sierra; Mario Fraga; Julia Mayerle; Günter Klöppel; Juan Cadiñanos; Pentao Liu; George Vassiliou; Wilko Weichert; Katja Steiger; Wolfgang Enard; Roland M Schmid; Fengtang Yang; Kristian Unger; Günter Schneider; Ignacio Varela; Allan Bradley; Dieter Saur; Roland Rad
Journal:  Nature       Date:  2018-01-24       Impact factor: 49.962

10.  HNF1A recruits KDM6A to activate differentiated acinar cell programs that suppress pancreatic cancer.

Authors:  Mark Kalisz; Edgar Bernardo; Anthony Beucher; Miguel Angel Maestro; Natalia Del Pozo; Irene Millán; Lena Haeberle; Martin Schlensog; Sami Alexander Safi; Wolfram Trudo Knoefel; Vanessa Grau; Matías de Vas; Karl B Shpargel; Eva Vaquero; Terry Magnuson; Sagrario Ortega; Irene Esposito; Francisco X Real; Jorge Ferrer
Journal:  EMBO J       Date:  2020-03-10       Impact factor: 11.598
View more
  1 in total

Review 1.  The SUMO pathway in pancreatic cancer: insights and inhibition.

Authors:  Christian Schneeweis; Zonera Hassan; Markus Schick; Ulrich Keller; Günter Schneider
Journal:  Br J Cancer       Date:  2020-10-19       Impact factor: 7.640
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.