| Literature DB >> 32234405 |
Paola Conigliaro1, Arianna D'Antonio2, Sara Pinto3, Maria Sole Chimenti2, Paola Triggianese2, Mario Rotondi3, Roberto Perricone2.
Abstract
Rheumatoid arthritis (RA) and autoimmune thyroid disease (AITD) can occur in the same patient in the autoimmune polyglandular syndrome 2. The association of the two conditions has been recognized long-time ago and the prevalence of AITD in patients with RA and vice versa is well assessed. Geographical variation of AITD and related autoantibodies in RA patients is partly due to ethnic and environmental differences of the studied populations. The impacts of thyroid disorders on RA outcome and vice versa are still controversy. In both AITD and RA genetic susceptibility and environmental factors play a synergic role in the development of the diseases. In this review we aimed at investigating the association of AITD and thyroid autoantibodies with RA, the common pathogenic pathways, the correlation with RA disease activity, and influence of the treatment.Entities:
Keywords: Autoimmune thyroid disease; Graves's disease; Hashimoto's thyroiditis; Rheumatoid arthritis; Treatment
Year: 2020 PMID： 32234405 DOI： 10.1016/j.autrev.2020.102529
Source DB: PubMed Journal: Autoimmun Rev ISSN： 1568-9972 Impact factor: 9.754