| Literature DB >> 32234372 |
Si-Yuan Luo1, Rong Pu2, Ya-Qi Tang1, Run-Zhu Fan1, Sheng Yin1, Gui-Hua Tang3.
Abstract
Four new tetracyclic triterpenoids (1-4) were isolated from the leaves and twigs of Jatropha gossypiifolia. Their structures were elucidated by MS and NMR data analysis, together with the Mo2(OAc)4-induced CD data. Jagabeoeuphols A-C (1-3) are rare 19(10 → 9)abeo-euphane-type triterpenoids possessing a Δ5(10) group and a 7,8-epoxide moiety, and jagoseuphone A (4) is a typical euphane-type triterpenoid. The inhibitory effects of 1-4 on nitric oxide production induced by lipopolysaccharide in RAW264.7 cells were evaluated, and 4 exhibited moderate inhibitory activity with an IC50 value of 20.1 μM.Entities:
Keywords: 19(10 → 9)abeo-Euphane triterpenoids; Anti-inflammatory activity; Euphorbiaceae; Jatropha gossypiifolia
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Year: 2020 PMID： 32234372 DOI： 10.1016/j.fitote.2020.104582
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882