Literature DB >> 32233986

Controversies around the function of LARP1.

Andrea J Berman1, Carson C Thoreen2, Zinaida Dedeic3, James Chettle3, Philippe P Roux4, Sarah P Blagden3.   

Abstract

The RNA-binding protein LARP1 has generated interest in recent years for its role in the mTOR signalling cascade and its regulation of terminal oligopyrimidine (TOP) mRNA translation. Paradoxically, some scientists have shown that LARP1 represses TOP translation while others that LARP1 activates it. Here, we present opinions from four leading scientists in the field to discuss these and other contradictory findings.

Entities:  

Keywords:  LARP; LARP1; La-related protein 1; PABP; cancer; mRNA; mTOR; mTORC1; poly A binding protein; translation

Year:  2020        PMID： 32233986      PMCID： PMC7928164          DOI： 10.1080/15476286.2020.1733787

Source DB:  PubMed          Journal:  RNA Biol        ISSN： 1547-6286            Impact factor:   4.652


  59 in total

Review 1.  Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy.

Authors:  Seth A Wander; Bryan T Hennessy; Joyce M Slingerland
Journal:  J Clin Invest       Date:  2011-04-01       Impact factor: 14.808

2.  The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner.

Authors:  Ilona Patursky-Polischuk; Miri Stolovich-Rain; Mirit Hausner-Hanochi; Judith Kasir; Nadine Cybulski; Joseph Avruch; Markus A Rüegg; Michael N Hall; Oded Meyuhas
Journal:  Mol Cell Biol       Date:  2008-12-01       Impact factor: 4.272

3.  A comprehensive analysis of the La-motif protein superfamily.

Authors:  Cécile Bousquet-Antonelli; Jean-Marc Deragon
Journal:  RNA       Date:  2009-03-19       Impact factor: 4.942

4.  MicroRNA-26a/b directly regulate La-related protein 1 and inhibit cancer cell invasion in prostate cancer.

Authors:  Mayuko Kato; Yusuke Goto; Ryosuke Matsushita; Akira Kurozumi; Ichiro Fukumoto; Rika Nishikawa; Shinichi Sakamoto; Hideki Enokida; Masayuki Nakagawa; Tomohiko Ichikawa; Naohiko Seki
Journal:  Int J Oncol       Date:  2015-06-10       Impact factor: 5.650

5.  LARP1 is regulated by the XIST/miR-374a axis and functions as an oncogene in non-small cell lung carcinoma.

Authors:  Zhizheng Xu; Jing Xu; Huoquan Lu; Bin Lin; Shaopeng Cai; Jun Guo; Farong Zang; Rui Chen
Journal:  Oncol Rep       Date:  2017-10-17       Impact factor: 3.906

6.  The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration.

Authors:  Carla Burrows; Normala Abd Latip; Sarah-Jane Lam; Lee Carpenter; Kirsty Sawicka; George Tzolovsky; Hani Gabra; Martin Bushell; David M Glover; Anne E Willis; Sarah P Blagden
Journal:  Nucleic Acids Res       Date:  2010-04-29       Impact factor: 16.971

7.  La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability.

Authors:  Ruiqing Yang; Sergei A Gaidamakov; Jingwei Xie; Joowon Lee; Luigi Martino; Guennadi Kozlov; Amanda K Crawford; Amy N Russo; Maria R Conte; Kalle Gehring; Richard J Maraia
Journal:  Mol Cell Biol       Date:  2010-11-22       Impact factor: 4.272

8.  Capturing the Mechanism Underlying TOP mRNA Binding to LARP1.

Authors:  Kevin C Cassidy; Roni M Lahr; Jesse C Kaminsky; Stephanie Mack; Bruno D Fonseca; Subha R Das; Andrea J Berman; Jacob D Durrant
Journal:  Structure       Date:  2019-10-31       Impact factor: 5.006

Review 9.  The La-Related Proteins, a Family with Connections to Cancer.

Authors:  Chara Stavraka; Sarah Blagden
Journal:  Biomolecules       Date:  2015-10-16

10.  Overexpression of LARP1 predicts poor prognosis of colorectal cancer and is expected to be a potential therapeutic target.

Authors:  Ling Ye; Sheng-Tao Lin; Yu-Shuai Mi; Yuan Liu; Yang Ma; Hui-Min Sun; Zhi-Hai Peng; Jun-Wei Fan
Journal:  Tumour Biol       Date:  2016-09-10
View more
  12 in total

1.  Global analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis.

Authors:  Ng Desi; Qing Yun Tong; Velda Teh; Jia Jia Chan; Bin Zhang; Hossein Tabatabaeian; Hui Qing Tan; Katannya Kapeli; Wenhao Jin; Chun You Lim; Zhi Hao Kwok; Hwee Tong Tan; Shi Wang; Bei-En Siew; Kuok-Chung Lee; Choon-Seng Chong; Ker-Kan Tan; Henry Yang; Dennis Kappei; Gene W Yeo; Maxey Ching Ming Chung; Yvonne Tay
Journal:  Cell Mol Life Sci       Date:  2022-02-23       Impact factor: 9.261

Review 2.  The Translational Regulation in mTOR Pathway.

Authors:  Miaomiao Yang; Yanming Lu; Weilan Piao; Hua Jin
Journal:  Biomolecules       Date:  2022-06-08

3.  A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis.

Authors:  Elliot T Martin; Patrick Blatt; Elaine Nguyen; Roni Lahr; Sangeetha Selvam; Hyun Ah M Yoon; Tyler Pocchiari; Shamsi Emtenani; Daria E Siekhaus; Andrea Berman; Gabriele Fuchs; Prashanth Rangan
Journal:  Dev Cell       Date:  2022-04-11       Impact factor: 13.417

4.  Parallel global profiling of plant TOR dynamics reveals a conserved role for LARP1 in translation.

Authors:  M Regina Scarpin; Samuel Leiboff; Jacob O Brunkard
Journal:  Elife       Date:  2020-10-15       Impact factor: 8.140

Review 5.  LARP1 and LARP4: up close with PABP for mRNA 3' poly(A) protection and stabilization.

Authors:  Sandy Mattijssen; Guennadi Kozlov; Bruno D Fonseca; Kalle Gehring; Richard J Maraia
Journal:  RNA Biol       Date:  2021-01-31       Impact factor: 4.652

6.  The isolated La-module of LARP1 mediates 3' poly(A) protection and mRNA stabilization, dependent on its intrinsic PAM2 binding to PABPC1.

Authors:  Sandy Mattijssen; Guennadi Kozlov; Sergei Gaidamakov; Amitabh Ranjan; Bruno D Fonseca; Kalle Gehring; Richard J Maraia
Journal:  RNA Biol       Date:  2020-12-23       Impact factor: 4.652

Review 7.  Role of Cyclin-Dependent Kinase 1 in Translational Regulation in the M-Phase.

Authors:  Jaroslav Kalous; Denisa Jansová; Andrej Šušor
Journal:  Cells       Date:  2020-06-27       Impact factor: 6.600

8.  The RNA-binding protein LARP1 is dispensable for pancreatic β-cell function and mass.

Authors:  Joao Pedro Werneck-de-Castro; Flavia Leticia Martins Peçanha; Diego Henrique Silvestre; Ernesto Bernal-Mizrachi
Journal:  Sci Rep       Date:  2021-01-22       Impact factor: 4.996

Review 9.  Molecular Regulation of Skeletal Muscle Growth and Organelle Biosynthesis: Practical Recommendations for Exercise Training.

Authors:  Robert Solsona; Laura Pavlin; Henri Bernardi; Anthony Mj Sanchez
Journal:  Int J Mol Sci       Date:  2021-03-08       Impact factor: 5.923

Review 10.  Membrane-Associated Flavivirus Replication Complex-Its Organization and Regulation.

Authors:  Eiji Morita; Youichi Suzuki
Journal:  Viruses       Date:  2021-06-03       Impact factor: 5.048
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.