Literature DB >> 32232889

Subtype-specific cardiomyocytes for precision medicine: Where are we now?

Ming-Tao Zhao1,2, Ning-Yi Shao3, Vidu Garg1,2,4.   

Abstract

Patient-derived pluripotent stem cells (PSCs) have greatly transformed the current understanding of human heart development and cardiovascular disease. Cardiomyocytes derived from personalized PSCs are powerful tools for modeling heart disease and performing patient-based cardiac toxicity testing. However, these PSC-derived cardiomyocytes (PSC-CMs) are a mixed population of atrial-, ventricular-, and pacemaker-like cells in the dish, hindering the future of precision cardiovascular medicine. Recent insights gleaned from the developing heart have paved new avenues to refine subtype-specific cardiomyocytes from patients with known pathogenic genetic variants and clinical phenotypes. Here, we discuss the recent progress on generating subtype-specific (atrial, ventricular, and nodal) cardiomyocytes from the perspective of embryonic heart development and how human pluripotent stem cells will expand our current knowledge on molecular mechanisms of cardiovascular disease and the future of precision medicine. © AlphaMed Press 2020.

Entities:  

Keywords:  atrial cardiomyocytes; human pluripotent stem cells; nodal cardiomyocytes; subtype-specific cardiomyocytes; ventricular cardiomyocytes

Mesh：

Year:  2020        PMID： 32232889      PMCID： PMC7529810          DOI： 10.1002/stem.3178

Source DB:  PubMed          Journal:  Stem Cells        ISSN： 1066-5099            Impact factor:   5.845


  126 in total

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Authors:  Guillermo Luxán; Gaetano D'Amato; Donal MacGrogan; José Luis de la Pompa
Journal:  Circ Res       Date:  2015-12-03       Impact factor: 17.367

2.  Formation of the venous pole of the heart from an Nkx2-5-negative precursor population requires Tbx18.

Authors:  Vincent M Christoffels; Mathilda T M Mommersteeg; Mark-Oliver Trowe; Owen W J Prall; Corrie de Gier-de Vries; Alexandre T Soufan; Markus Bussen; Karin Schuster-Gossler; Richard P Harvey; Antoon F M Moorman; Andreas Kispert
Journal:  Circ Res       Date:  2006-05-18       Impact factor: 17.367

3.  Isolation and characterization of ventricular-like cells derived from NKX2-5eGFP/w and MLC2vmCherry/w double knock-in human pluripotent stem cells.

Authors:  Kaori Yamauchi; Junjun Li; Kumi Morikawa; Li Liu; Yasuaki Shirayoshi; Norio Nakatsuji; David A Elliott; Ichiro Hisatome; Hirofumi Suemori
Journal:  Biochem Biophys Res Commun       Date:  2017-11-22       Impact factor: 3.575

Review 4.  Coordinating tissue interactions: Notch signaling in cardiac development and disease.

Authors:  José Luis de la Pompa; Jonathan A Epstein
Journal:  Dev Cell       Date:  2012-02-14       Impact factor: 12.270

5.  Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell-Derived Cardiomyocytes Elucidate Single-Cell Phenotype of Brugada Syndrome.

Authors:  Ping Liang; Karim Sallam; Haodi Wu; Yingxin Li; Ilanit Itzhaki; Priyanka Garg; Ying Zhang; Vittavat Vermglinchan; Feng Lan; Mingxia Gu; Tingyu Gong; Yan Zhuge; Chunjiang He; Antje D Ebert; Veronica Sanchez-Freire; Jared Churko; Shijun Hu; Arun Sharma; Chi Keung Lam; Melvin M Scheinman; Donald M Bers; Joseph C Wu
Journal:  J Am Coll Cardiol       Date:  2016-11-08       Impact factor: 24.094

6.  Canonical Wnt5b Signaling Directs Outlying Nkx2.5+ Mesoderm into Pacemaker Cardiomyocytes.

Authors:  Jie Ren; Peidong Han; Xuanyi Ma; Elie N Farah; Joshua Bloomekatz; Xin-Xin I Zeng; Ruilin Zhang; Megan M Swim; Alec D Witty; Hannah G Knight; Rima Deshpande; Weizhe Xu; Deborah Yelon; Shaochen Chen; Neil C Chi
Journal:  Dev Cell       Date:  2019-08-08       Impact factor: 12.270

7.  Notch signaling regulates smooth muscle differentiation of epicardium-derived cells.

Authors:  Thomas Grieskamp; Carsten Rudat; Timo H-W Lüdtke; Julia Norden; Andreas Kispert
Journal:  Circ Res       Date:  2011-01-20       Impact factor: 17.367

8.  Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology.

Authors:  Harsha D Devalla; Verena Schwach; John W Ford; James T Milnes; Said El-Haou; Claire Jackson; Konstantinos Gkatzis; David A Elliott; Susana M Chuva de Sousa Lopes; Christine L Mummery; Arie O Verkerk; Robert Passier
Journal:  EMBO Mol Med       Date:  2015-04       Impact factor: 12.137

9.  A COUP-TFII Human Embryonic Stem Cell Reporter Line to Identify and Select Atrial Cardiomyocytes.

Authors:  Verena Schwach; Arie O Verkerk; Mervyn Mol; Jantine J Monshouwer-Kloots; Harsha D Devalla; Valeria V Orlova; Konstantinos Anastassiadis; Christine L Mummery; Richard P Davis; Robert Passier
Journal:  Stem Cell Reports       Date:  2017-11-22       Impact factor: 7.765

10.  Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis.

Authors:  Jared M Churko; Priyanka Garg; Barbara Treutlein; Meenakshi Venkatasubramanian; Haodi Wu; Jaecheol Lee; Quinton N Wessells; Shih-Yu Chen; Wen-Yi Chen; Kashish Chetal; Gary Mantalas; Norma Neff; Eric Jabart; Arun Sharma; Garry P Nolan; Nathan Salomonis; Joseph C Wu
Journal:  Nat Commun       Date:  2018-11-21       Impact factor: 14.919
View more
  10 in total

Review 1.  Probing single ventricle heart defects with patient-derived induced pluripotent stem cells and emerging technologies.

Authors:  Bailey Hall; Matthew Alonzo; Karen Texter; Vidu Garg; Ming-Tao Zhao
Journal:  Birth Defects Res       Date:  2022-02-24       Impact factor: 2.661

Review 2.  Human-induced pluripotent stem cells in cardiovascular research: current approaches in cardiac differentiation, maturation strategies, and scalable production.

Authors:  Dilip Thomas; Nathan J Cunningham; Sushma Shenoy; Joseph C Wu
Journal:  Cardiovasc Res       Date:  2022-01-07       Impact factor: 10.787

Review 3.  Differentiation and Application of Human Pluripotent Stem Cells Derived Cardiovascular Cells for Treatment of Heart Diseases: Promises and Challenges.

Authors:  Yu Gao; Jun Pu
Journal:  Front Cell Dev Biol       Date:  2021-05-12

4.  A dual SHOX2:GFP; MYH6:mCherry knockin hESC reporter line for derivation of human SAN-like cells.

Authors:  Zaniar Ghazizadeh; Jiajun Zhu; Faranak Fattahi; Alice Tang; Xiaolu Sun; Sadaf Amin; Su-Yi Tsai; Mona Khalaj; Ting Zhou; Ryan M Samuel; Tuo Zhang; Francis A Ortega; Miriam Gordillo; Dorota Moroziewicz; Daniel Paull; Scott A Noggle; Jenny Zhaoying Xiang; Lorenz Studer; David J Christini; Geoffrey S Pitt; Todd Evans; Shuibing Chen
Journal:  iScience       Date:  2022-03-25

Review 5.  Decoding Genetics of Congenital Heart Disease Using Patient-Derived Induced Pluripotent Stem Cells (iPSCs).

Authors:  Hui Lin; Kim L McBride; Vidu Garg; Ming-Tao Zhao
Journal:  Front Cell Dev Biol       Date:  2021-01-21

Review 6.  Cardiomyocyte Proliferation and Maturation: Two Sides of the Same Coin for Heart Regeneration.

Authors:  Ming-Tao Zhao; Shiqiao Ye; Juan Su; Vidu Garg
Journal:  Front Cell Dev Biol       Date:  2020-10-15

Review 7.  Bioengineering Clinically Relevant Cardiomyocytes and Cardiac Tissues from Pluripotent Stem Cells.

Authors:  Emma Claire James; Eva Tomaskovic-Crook; Jeremy Micah Crook
Journal:  Int J Mol Sci       Date:  2021-03-16       Impact factor: 5.923

Review 8.  Personalized Cell Therapy for Patients with Peripheral Arterial Diseases in the Context of Genetic Alterations: Artificial Intelligence-Based Responder and Non-Responder Prediction.

Authors:  Amankeldi A Salybekov; Markus Wolfien; Shuzo Kobayashi; Gustav Steinhoff; Takayuki Asahara
Journal:  Cells       Date:  2021-11-23       Impact factor: 6.600

9.  Ion Channel Expression and Electrophysiology of Singular Human (Primary and Induced Pluripotent Stem Cell-Derived) Cardiomyocytes.

Authors:  Christina Schmid; Najah Abi-Gerges; Michael Georg Leitner; Dietmar Zellner; Georg Rast
Journal:  Cells       Date:  2021-11-30       Impact factor: 6.600

Review 10.  Human Stem Cell Models of SARS-CoV-2 Infection in the Cardiovascular System.

Authors:  Kyle Ernzen; Aaron J Trask; Mark E Peeples; Vidu Garg; Ming-Tao Zhao
Journal:  Stem Cell Rev Rep       Date:  2021-08-08       Impact factor: 5.739
  10 in total

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