Literature DB >> 32229095

Anti-CD20-mediated B-cell depletion in autoimmune diseases: successes, failures and future perspectives.

Etienne Crickx1, Jean-Claude Weill2, Claude-Agnès Reynaud2, Matthieu Mahévas3.   

Abstract

B-cell depletion with anti-CD20 monoclonal antibodies is widely used for the treatment of autoimmune diseases. This review will discuss mechanisms contributing to success or failure of B-cell depletion therapy in antibody-mediated autoimmune diseases. It will also explain how key information about disease pathogeny can be provided by the different outcomes observed after B-cell depletion therapy. These findings provide the basis for future innovative therapeutic strategies aiming at an optimized B cell and/or plasma cell depletion to increase long-term disease remission.
Copyright © 2020 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  cell survival; systemic lupus erythematosus; vasculitis

Mesh：

Substances：

Year:  2020        PMID： 32229095     DOI： 10.1016/j.kint.2019.12.025

Source DB:  PubMed          Journal:  Kidney Int        ISSN： 0085-2538            Impact factor:   10.612


  9 in total

1.  High-affinity autoreactive plasma cells disseminate through multiple organs in patients with immune thrombocytopenic purpura.

Authors:  Pablo Canales-Herrerias; Etienne Crickx; Matteo Broketa; Aurélien Sokal; Guilhem Chenon; Imane Azzaoui; Alexis Vandenberghe; Angga Perima; Bruno Iannascoli; Odile Richard-Le Goff; Carlos Castrillon; Guillaume Mottet; Delphine Sterlin; Ailsa Robbins; Marc Michel; Patrick England; Gael A Millot; Klaus Eyer; Jean Baudry; Matthieu Mahevas; Pierre Bruhns
Journal:  J Clin Invest       Date:  2022-06-15       Impact factor: 19.456

Review 2.  Advances in Membranous Nephropathy.

Authors:  Pierre Ronco; Emmanuelle Plaisier; Hanna Debiec
Journal:  J Clin Med       Date:  2021-02-05       Impact factor: 4.241

Review 3.  Toll-like receptor signalling in B cells during systemic lupus erythematosus.

Authors:  Simon Fillatreau; Benoît Manfroi; Thomas Dörner
Journal:  Nat Rev Rheumatol       Date:  2020-12-18       Impact factor: 20.543

4.  Preparation and In Vitro Evaluation of RITUXfab-Decorated Lipoplexes to Improve Delivery of siRNA Targeting C1858T PTPN22 Variant in B Lymphocytes.

Authors:  Andrea Arena; Eugenia Belcastro; Antonella Accardo; Annamaria Sandomenico; Olivia Pagliarosi; Elisabetta Rosa; Stefania Petrini; Libenzio Adrian Conti; Ezio Giorda; Tiziana Corsetti; Riccardo Schiaffini; Giancarlo Morelli; Alessandra Fierabracci
Journal:  Int J Mol Sci       Date:  2021-12-30       Impact factor: 5.923

5.  Mixed Cryoglobulinaemia Vasculitis Treated with Obinutuzumab in a Patient Allergic to Rituximab.

Authors:  Margarida Gaudêncio; Catarina Parente; Ana Catarina Lameiras; António Marinho
Journal:  Eur J Case Rep Intern Med       Date:  2021-11-22

Review 6.  Targeted Immunotherapy for Autoimmune Disease.

Authors:  Seung Min Jung; Wan-Uk Kim
Journal:  Immune Netw       Date:  2022-02-17       Impact factor: 5.851

7.  Improvement of Lipoplexes With a Sialic Acid Mimetic to Target the C1858T PTPN22 Variant for Immunotherapy in Endocrine Autoimmunity.

Authors:  Andrea Arena; Eugenia Belcastro; Francesca Ceccacci; Stefania Petrini; Libenzio Adrian Conti; Olivia Pagliarosi; Ezio Giorda; Simona Sennato; Riccardo Schiaffini; Peng Wang; James C Paulson; Giovanna Mancini; Alessandra Fierabracci
Journal:  Front Immunol       Date:  2022-03-09       Impact factor: 7.561

Review 8.  Regulatory B cells in respiratory health and diseases.

Authors:  Madhvi Menon; Tracy Hussell; Halima Ali Shuwa
Journal:  Immunol Rev       Date:  2021-01-06       Impact factor: 10.983

9.  Long-term B cell depletion associates with regeneration of kidney function.

Authors:  Susanne V Fleig; Franz F Konen; Christoph Schröder; Jessica Schmitz; Stefan Gingele; Jan H Bräsen; Svjetlana Lovric; Bernhard M W Schmidt; Hermann Haller; Thomas Skripuletz; Sibylle von Vietinghoff
Journal:  Immun Inflamm Dis       Date:  2021-07-29
  9 in total

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