Literature DB >> 32227278

Commentary: rapamycin for the aging skin.

Christian Sell1.   

Abstract

A response is provided to a commentary on a recent study examining the impact of low-dose topical application of rapamycin on markers of aging in the skin. The barriers to clinical implementation of therapies targeting the fundamental aging process are discussed, and the topical study is placed in context with the broader effort to develop new therapeutics for age-related disorders.

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Year:  2020        PMID： 32227278      PMCID： PMC7206468          DOI： 10.1007/s11357-020-00184-2

Source DB:  PubMed          Journal:  Geroscience        ISSN： 2509-2723            Impact factor:   7.713


  17 in total

Review 1.  Rapamycin and Alzheimer's disease: Time for a clinical trial?

Authors:  Matt Kaeberlein; Veronica Galvan
Journal:  Sci Transl Med       Date:  2019-01-23       Impact factor: 17.956

2.  Sirolimus Gel Treatment vs Placebo for Facial Angiofibromas in Patients With Tuberous Sclerosis Complex: A Randomized Clinical Trial.

Authors:  Mari Wataya-Kaneda; Yuuki Ohno; Yasuyuki Fujita; Hiroo Yokozeki; Hironori Niizeki; Masaaki Ogai; Kazuyoshi Fukai; Hiroshi Nagai; Yuichi Yoshida; Izumi Hamada; Taihei Hio; Kenji Shimizu; Hiroyuki Murota
Journal:  JAMA Dermatol       Date:  2018-07-01       Impact factor: 10.282

Review 3.  mTOR inhibitors and diabetes.

Authors:  Bruno Vergès; Bertrand Cariou
Journal:  Diabetes Res Clin Pract       Date:  2015-09-21       Impact factor: 5.602

4.  A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs.

Authors:  Silvan R Urfer; Tammi L Kaeberlein; Susan Mailheau; Philip J Bergman; Kate E Creevy; Daniel E L Promislow; Matt Kaeberlein
Journal:  Geroscience       Date:  2017-04-03       Impact factor: 7.713

5.  Development of Clinical Trials to Extend Healthy Lifespan.

Authors:  Jamie N Justice; Laura Niedernhofer; Paul D Robbins; Vanita R Aroda; Mark A Espeland; Stephen B Kritchevsky; George A Kuchel; Nir Barzilai
Journal:  Cardiovasc Endocrinol Metab       Date:  2018-12

6.  Research to Promote Longevity and Health Span in Companion Dogs: A Pediatric Perspective.

Authors:  Benjamin S Wilfond; Kathryn M Porter; Kate E Creevy; Matt Kaeberlein; Daniel Promislow
Journal:  Am J Bioeth       Date:  2018-10       Impact factor: 11.229

7.  Maintaining skin integrity in the aged: A systematic review.

Authors:  A Lichterfeld-Kottner; M El Genedy; N Lahmann; U Blume-Peytavi; A Büscher; J Kottner
Journal:  Int J Nurs Stud       Date:  2019-12-23       Impact factor: 5.837

Review 8.  From discoveries in ageing research to therapeutics for healthy ageing.

Authors:  Judith Campisi; Pankaj Kapahi; Gordon J Lithgow; Simon Melov; John C Newman; Eric Verdin
Journal:  Nature       Date:  2019-07-10       Impact factor: 49.962

9.  Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial.

Authors:  Christina Lee Chung; Ibiyonu Lawrence; Melissa Hoffman; Dareen Elgindi; Kumar Nadhan; Manali Potnis; Annie Jin; Catlin Sershon; Rhonda Binnebose; Antonello Lorenzini; Christian Sell
Journal:  Geroscience       Date:  2019-11-25       Impact factor: 7.713

10.  Rapamycin for the aging skin.

Authors:  Mikhail V Blagosklonny
Journal:  Aging (Albany NY)       Date:  2019-12-27       Impact factor: 5.682
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