Xiaoyu Han1,2, Yukun Cao1,2, Nanchuan Jiang1,2, Yan Chen1,2, Osamah Alwalid1,2, Xin Zhang1,2, Jin Gu1,2, Meng Dai1,2, Jie Liu1,2, Wanyue Zhu3, Chuansheng Zheng1,2, Heshui Shi1,2. 1. Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, The People's Republic of China. 2. Hubei Province Key Laboratory of Molecular Imaging, Wuhan, The People's Republic of China. 3. Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, The People's Republic of China.
Abstract
BACKGROUND: Our objective was to retrospectively analyze the evolution of clinical features and thin-section computed tomography (CT) imaging of novel coronavirus disease 2019 (COVID-19) pneumonia in 17 discharged patients. METHODS: Serial thin-section CT scans of 17 discharged patients with COVID-19 were obtained during recovery. Longitudinal changes of clinical parameters and a CT pattern were documented in all patients during the 4 weeks after admission. A CT score was used to evaluate the extent of the disease. RESULTS: There were marked improvements of fever, lymphocyte counts, C-reactive proteins, and erythrocyte sedimentation rates within the first 2 weeks after admission. However, the mean CT score rapidly increased from the first to the third week, with a top score of 8.2 obtained in the second week. During the first week, the main CT pattern was ground-glass opacities (GGO; 76.5%). The frequency of GGO (52.9%) decreased in the second week. Consolidation and mixed patterns (47.0%) were noted in the second week. Thereafter, consolidations generally dissipated into GGO, and the frequency of GGO increased in the third week (76.5%) and fourth week (71.4%). Opacities were mainly located in the peripheral (76.5%) and subpleural (47.1%) zones of the lungs; they presented as focal (35.3%) or multifocal (29.4%) in the first week and became more diffuse in the second (47.1%) and third weeks (58.8%), then showed a reduced extent in fourth week (50%). CONCLUSIONS: The progression course of the CT pattern was later than the progression of the clinical parameters within the first 2 weeks after admission; however, there were synchronized improvements in both the clinical and radiologic features in the fourth week.
BACKGROUND: Our objective was to retrospectively analyze the evolution of clinical features and thin-section computed tomography (CT) imaging of novel coronavirus disease2019 (COVID-19) pneumonia in 17 discharged patients. METHODS: Serial thin-section CT scans of 17 discharged patients with COVID-19 were obtained during recovery. Longitudinal changes of clinical parameters and a CT pattern were documented in all patients during the 4 weeks after admission. A CT score was used to evaluate the extent of the disease. RESULTS: There were marked improvements of fever, lymphocyte counts, C-reactive proteins, and erythrocyte sedimentation rates within the first 2 weeks after admission. However, the mean CT score rapidly increased from the first to the third week, with a top score of 8.2 obtained in the second week. During the first week, the main CT pattern was ground-glass opacities (GGO; 76.5%). The frequency of GGO (52.9%) decreased in the second week. Consolidation and mixed patterns (47.0%) were noted in the second week. Thereafter, consolidations generally dissipated into GGO, and the frequency of GGO increased in the third week (76.5%) and fourth week (71.4%). Opacities were mainly located in the peripheral (76.5%) and subpleural (47.1%) zones of the lungs; they presented as focal (35.3%) or multifocal (29.4%) in the first week and became more diffuse in the second (47.1%) and third weeks (58.8%), then showed a reduced extent in fourth week (50%). CONCLUSIONS: The progression course of the CT pattern was later than the progression of the clinical parameters within the first 2 weeks after admission; however, there were synchronized improvements in both the clinical and radiologic features in the fourth week.
Authors: Saad Alhumaid; Abbas Al Mutair; Zainab Al Alawi; Khulud Al Salman; Nourah Al Dossary; Ahmed Omar; Mossa Alismail; Ali M Al Ghazal; Mahdi Bu Jubarah; Hanan Al Shaikh; Maher M Al Mahdi; Sarah Y Alsabati; Dayas K Philip; Mohammed Y Alyousef; Abdulsatar H Al Brahim; Maitham S Al Athan; Salamah A Alomran; Hatim S Ahmed; Haifa Al-Shammari; Alyaa Elhazmi; Ali A Rabaan; Jaffar A Al-Tawfiq; Awad Al-Omari Journal: Eur J Med Res Date: 2021-05-24 Impact factor: 2.175
Authors: Shahabedin Nabavi; Azar Ejmalian; Mohsen Ebrahimi Moghaddam; Ahmad Ali Abin; Alejandro F Frangi; Mohammad Mohammadi; Hamidreza Saligheh Rad Journal: Comput Biol Med Date: 2021-06-23 Impact factor: 6.698