Fabio Nicoli1,2,3, Daniel B Saleh1, Bence Baljer1,2, Corey D Chan2, Tom Beckingsale4, Kanishka M Ghosh4, Maniram Ragbir1, Kenneth S Rankin2,4. 1. Department of Plastic and Reconstructive Surgery, Royal Victoria Infirmary Hospital Newcastle NHS Foundation Trust, Newcastle upon Tyne, UK. 2. Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK. 3. Department of Plastic and Reconstructive Surgery, Northumbria Healthcare NHS Foundation Trust, Northumberland, UK. 4. North of England Bone and Soft Tissue Tumour Service, Freeman Hospital Newcastle NHS Foundation Trust, Newcastle upon Tyne, UK.
Abstract
BACKGROUND: Complete excision of sarcomas to maximize function without compromising the oncological outcome can be challenging. The aim of this study was to investigate the feasibility and potential drawbacks of near-infrared (NIR) fluorescence imaging with indocyanine green during resection of bone and soft tissue sarcomas. METHODS: Eleven patients with high-grade sarcomas were enrolled in the study. All patients received intravenous indocyanine green (75 mg) between 16 and 24 hours before the resection. Sarcomas were resected under NIR guidance and specimens were sent for routine histopathological analysis. RESULTS: Majority of treatment naive tumors demonstrated fluorescence. There were no adverse events from the indocyanine green administration. In 3 cases, the fluorescence was reported by the surgeon to have been of definite guidance leading to further tissue resection to improve the margin. CONCLUSION: This is the first report of NIR fluorescence guidance in the setting of open sarcoma surgery. The technique is acceptable to patients and surgeons and was able to guide resection. Multicenter studies are required to assess the utility of this technique in a large cohort of patients with regards to quantification of fluorescence, resection guidance, and longer follow-up period.
BACKGROUND: Complete excision of sarcomas to maximize function without compromising the oncological outcome can be challenging. The aim of this study was to investigate the feasibility and potential drawbacks of near-infrared (NIR) fluorescence imaging with indocyanine green during resection of bone and soft tissue sarcomas. METHODS: Eleven patients with high-grade sarcomas were enrolled in the study. All patients received intravenous indocyanine green (75 mg) between 16 and 24 hours before the resection. Sarcomas were resected under NIR guidance and specimens were sent for routine histopathological analysis. RESULTS: Majority of treatment naive tumors demonstrated fluorescence. There were no adverse events from the indocyanine green administration. In 3 cases, the fluorescence was reported by the surgeon to have been of definite guidance leading to further tissue resection to improve the margin. CONCLUSION: This is the first report of NIR fluorescence guidance in the setting of open sarcoma surgery. The technique is acceptable to patients and surgeons and was able to guide resection. Multicenter studies are required to assess the utility of this technique in a large cohort of patients with regards to quantification of fluorescence, resection guidance, and longer follow-up period.
Authors: Toni A Pringle; Corey D Chan; Saimir Luli; Helen J Blair; Kenneth S Rankin; James C Knight Journal: Bioconjug Chem Date: 2022-07-22 Impact factor: 6.069
Authors: Marcus J Brookes; Corey D Chan; Fabio Nicoli; Timothy P Crowley; Kanishka M Ghosh; Thomas Beckingsale; Daniel Saleh; Petra Dildey; Sanjay Gupta; Maniram Ragbir; Kenneth S Rankin Journal: Cancers (Basel) Date: 2021-12-14 Impact factor: 6.639
Authors: Mohammed H A Alramdan; Ömer Kasalak; Lukas B Been; Albert J H Suurmeijer; Derya Yakar; Thomas C Kwee Journal: Skeletal Radiol Date: 2021-04-26 Impact factor: 2.199
Authors: Gijsbert M Kalisvaart; Ruben P J Meijer; Okker D Bijlstra; Hidde A Galema; Wobbe O de Steur; Henk H Hartgrink; Cornelis Verhoef; Lioe-Fee de Geus-Oei; Dirk J Grünhagen; Yvonne M Schrage; Alexander L Vahrmeijer; Jos A van der Hage Journal: Cancers (Basel) Date: 2022-03-18 Impact factor: 6.639