Enzymatic modification to produce health-promoting lipids from fish oil, algae and other new omega-3 sources: A review.

Lipases are a versatile class of enzymes that have aroused great interest in the food and pharmaceutical industries due to their ability to modify and synthesize new lipids for functional foods. Omega-3 polyunsaturated fatty acids (omega-3 PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have shown important biological functions promoting human health, especially in the development and maintenance of brain function and vision. Lipases allow selective production of functional lipids enriched in omega-3 PUFAs and are unique enzymatic tools to improve the natural composition of lipids and provide specific bioactivities. This review comprises recent research trends on the enzymatic production of bioactive, structured lipids with improved nutritional characteristics, using new enzymatic processing technologies in combination with novel raw materials, including microalgal lipids and new seed oils high in omega-3 fatty acids. An extensive number of lipase applications in the synthesis of health-promoting lipids enriched in omega-3 fatty acids by enzymatic modification is reviewed, considering the main advances in recent years for production of ethyl esters, 2-monoacylglycerols and structured triglycerides and phospholipids with omega-3 fatty acids, in order to achieve bioactive lipids as new foods and drugs.