Literature DB >> 32224121

Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned.

Ryan Choi1, Matthew A Hulverson1, Wenlin Huang2, Rama S R Vidadala3, Grant R Whitman1, Lynn K Barrett1, Deborah A Schaefer4, Dana P Betzer4, Michael W Riggs4, J Stone Doggett5, Andrew Hemphill6, Luis Miguel Ortega-Mora7, Molly C McCloskey1, Samuel L M Arnold1, Robert C Hackman8, Kennan C Marsh9, James J Lynch9, Gail M Freiberg9, Bruce E Leroy9, Dale J Kempf9, Robert K M Choy10, Eugenio L de Hostos10, Dustin J Maly3, Erkang Fan2, Kayode K Ojo1, Wesley C Van Voorhis11.   

Abstract

Bumped Kinase Inhibitors, targeting Calcium-dependent Protein Kinase 1 in apicomplexan parasites with a glycine gatekeeper, are promising new therapeutics for apicomplexan diseases. Here we will review advances, as well as challenges and lessons learned regarding efficacy, safety, and pharmacology that have shaped our selection of pre-clinical candidates.
Copyright © 2020. Published by Elsevier Ltd.

Entities:  

Keywords:  Apicomplexa; Bumped Kinase Inhibitor; Calcium-dependent Protein Kinases; Cryptosporidium; Gatekeeper; Neospora; Sarcocystis; Toxoplasma

Mesh：

Substances：

Year:  2020        PMID： 32224121     DOI： 10.1016/j.ijpara.2020.01.006

Source DB:  PubMed          Journal:  Int J Parasitol        ISSN： 0020-7519            Impact factor:   3.981


  10 in total

1.  Assembling Pharma Resources to Tackle Diseases of Underserved Populations.

Authors:  Dale J Kempf; Kennan C Marsh
Journal:  ACS Med Chem Lett       Date:  2020-03-27       Impact factor: 4.345

2.  Vaccine-Linked Chemotherapy Approach: Additive Effects of Combining the Listeria monocytogenes-Based Vaccine Lm3Dx_NcSAG1 With the Bumped Kinase Inhibitor BKI-1748 Against Neospora caninum Infection in Mice.

Authors:  Dennis Imhof; William Robert Pownall; Carling Schlange; Camille Monney; Luis-Miguel Ortega-Mora; Kayode K Ojo; Wesley C Van Voorhis; Anna Oevermann; Andrew Hemphill
Journal:  Front Vet Sci       Date:  2022-06-27

Review 3.  An Overview of Mucosa-Associated Protozoa: Challenges in Chemotherapy and Future Perspectives.

Authors:  Helena Lucia Carneiro Santos; Karina M Rebello
Journal:  Front Cell Infect Microbiol       Date:  2022-04-25       Impact factor: 6.073

Review 4.  Use-case scenarios for an anti-Cryptosporidium therapeutic.

Authors:  Paul G Ashigbie; Susan Shepherd; Kevin L Steiner; Beatrice Amadi; Natasha Aziz; Ujjini H Manjunatha; Jonathan M Spector; Thierry T Diagana; Paul Kelly
Journal:  PLoS Negl Trop Dis       Date:  2021-03-11

5.  Common Molecular Targets of a Quinolone Based Bumped Kinase Inhibitor in Neospora caninum and Danio rerio.

Authors:  Joachim Müller; Nicoleta Anghel; Dennis Imhof; Kai Hänggeli; Anne-Christine Uldry; Sophie Braga-Lagache; Manfred Heller; Kayode K Ojo; Luis-Miguel Ortega-Mora; Wesley C Van Voorhis; Andrew Hemphill
Journal:  Int J Mol Sci       Date:  2022-02-21       Impact factor: 5.923

6.  High-Throughput Screening of a Marine Compound Library Identifies Anti-Cryptosporidium Activity of Leiodolide A.

Authors:  Rachel M Bone Relat; Priscilla L Winder; Gregory D Bowden; Esther A Guzmán; Tara A Peterson; Shirley A Pomponi; Jill C Roberts; Amy E Wright; Roberta M O'Connor
Journal:  Mar Drugs       Date:  2022-03-30       Impact factor: 6.085

7.  Optimization of the Urea Linker of Triazolopyridazine MMV665917 Results in a New Anticryptosporidial Lead with Improved Potency and Predicted hERG Safety Margin.

Authors:  Edmund Oboh; Tanner J Schubert; Jose E Teixeira; Erin E Stebbins; Peter Miller; Emily Philo; Haresh Thakellapalli; Scott D Campbell; David W Griggs; Christopher D Huston; Marvin J Meyers
Journal:  J Med Chem       Date:  2021-08-03       Impact factor: 8.039

Review 8.  Emerging treatment options for cryptosporidiosis.

Authors:  Melissa S Love; Robert K M Choy
Journal:  Curr Opin Infect Dis       Date:  2021-10-01       Impact factor: 4.968

9.  The Impact of BKI-1294 Therapy in Mice Infected With the Apicomplexan Parasite Neospora caninum and Re-infected During Pregnancy.

Authors:  Pablo Winzer; Dennis Imhof; Nicoleta Anghel; Dominic Ritler; Joachim Müller; Ghalia Boubaker; Adriana Aguado-Martinez; Luis-Miguel Ortega-Mora; Kayode K Ojo; Wesley C VanVoorhis; Andrew Hemphill
Journal:  Front Vet Sci       Date:  2020-10-15

10.  A Conditional Protein Degradation System To Study Essential Gene Function in Cryptosporidium parvum.

Authors:  Hadi H Choudhary; Maria G Nava; Brina E Gartlan; Savannah Rose; Sumiti Vinayak
Journal:  mBio       Date:  2020-08-25       Impact factor: 7.786
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.