Jia-Wei Zhang1, Jia-Jia Liu1, Ting Huang1, Ying-Ying Zhao1, Lei Cai2, Zhi-Qiang Chen2. 1. School of Clinical Medicine, Ningxia Medical University, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China. 2. Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China.
Abstract
OBJECTIVE: To evaluate the expressions of P504s, 34β-E12, and P63 proteins in PCa and the correlation between the parameters of multi-modality MRI and the expression of P504s. METHODS: We retrospectively analyzed the multi-modality MRI data on 43 PCa and 64 non-PCa patients. We obtained the signal intensity-time (SI-T) curves, maximum SI (SImax), time to SImax (Tmax), rate of maximum enhancement (Rmax), and automatically generated apparent diffusion coefficient (ADC) values by conventional, diffusion-weighted and dynamic contrast-enhanced MRI, and determined the expressions of P504s, 34β-E12 and P63 in the prostatic tissues of the patients by immunohistochemistry. RESULTS: Statistically significant differences were observed between the PCa and non-PCa groups in the positive expressions of P504s (83.7% vs 0%, P < 0.05), 34β-E12 (25.6% vs 91.0%, P < 0.05) and P63 (25.6% vs 86.0%, P < 0.05) in the prostatic tissue, the ADC value (［0.83 ± 0.22］ vs ［1.34 ± 0.28］ ×10－3mm2/s, P < 0.05), Tmax (［21.30 ± 10.78］ vs ［50.22 ± 36.31］ s, P < 0.05), SImax (［1.75 ± 0.39］% vs ［1.24 ± 0.41］%, P < 0.05), and Rmax (［20.20 ± 15.50］% vs ［7.98 ± 6.25］%, P < 0.05). The expression of P504s was correlated negatively with the ADC value and Tmax (r = －0.60 and －0.37, P < 0.01) but positively with SImax and Rmax (r = 0.50 and 0.45, P < 0.01). CONCLUSIONS: The parameters of multi-modality MRI are correlated with the expression of P504s in PCa and can be used as imaging biomarkers for predicting the degrees of its malignancy.
OBJECTIVE: To evaluate the expressions of P504s, 34β-E12, and P63 proteins in PCa and the correlation between the parameters of multi-modality MRI and the expression of P504s. METHODS: We retrospectively analyzed the multi-modality MRI data on 43 PCa and 64 non-PCa patients. We obtained the signal intensity-time (SI-T) curves, maximum SI (SImax), time to SImax (Tmax), rate of maximum enhancement (Rmax), and automatically generated apparent diffusion coefficient (ADC) values by conventional, diffusion-weighted and dynamic contrast-enhanced MRI, and determined the expressions of P504s, 34β-E12 and P63 in the prostatic tissues of the patients by immunohistochemistry. RESULTS: Statistically significant differences were observed between the PCa and non-PCa groups in the positive expressions of P504s (83.7% vs 0%, P < 0.05), 34β-E12 (25.6% vs 91.0%, P < 0.05) and P63 (25.6% vs 86.0%, P < 0.05) in the prostatic tissue, the ADC value (［0.83 ± 0.22］ vs ［1.34 ± 0.28］ ×10－3mm2/s, P < 0.05), Tmax (［21.30 ± 10.78］ vs ［50.22 ± 36.31］ s, P < 0.05), SImax (［1.75 ± 0.39］% vs ［1.24 ± 0.41］%, P < 0.05), and Rmax (［20.20 ± 15.50］% vs ［7.98 ± 6.25］%, P < 0.05). The expression of P504s was correlated negatively with the ADC value and Tmax (r = －0.60 and －0.37, P < 0.01) but positively with SImax and Rmax (r = 0.50 and 0.45, P < 0.01). CONCLUSIONS: The parameters of multi-modality MRI are correlated with the expression of P504s in PCa and can be used as imaging biomarkers for predicting the degrees of its malignancy.
Entities:
Keywords:
34β-E12; P504s; P63zzm321990zzm321990 ; multi-modality MRI; prostate cancer