Kenzo Hiroshima1,2,3, Akihiko Yoshizawa4, Akemi Takenaka5, Reiji Haba6, Kunimitsu Kawahara7, Yuko Minami8, Hirokuni Kakinuma9, Yasuo Shibuki10, Shinji Miyake11, Kenta Kajio7, Kana Miyamoto6, Moe Nagatomo5, Sanako Nishimura12, Masayuki Mano5, Jun Matsubayashi13, Noriko Motoi10, Toshitaka Nagao13, Shin-Ichi Nakatsuka12, Tsutomu Yoshida14, Yukitoshi Satoh15. 1. Department of Pathology, Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo, Japan, hiroshima.kenzo@twmu.ac.jp. 2. Department of Biochemistry and Genetics, Chiba University Graduate School of Medicine, Chiba, Japan, hiroshima.kenzo@twmu.ac.jp. 3. Sodegaura Satsukidai Hospital, Sodegaura, Japan, hiroshima.kenzo@twmu.ac.jp. 4. Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan. 5. Department of Central Laboratory and Surgical Pathology, National Hospital Organization Osaka National Hospital, Osaka, Japan. 6. Department of Diagnostic Pathology, Kagawa University Hospital, Kagawa, Japan. 7. Department of Pathology, Osaka Habikino Medical Center, Osaka, Japan. 8. Department of Diagnostic Pathology, National Organization Hospital Ibarakihigashi National Hospital, The Center of Chest Diseases and Severe Motor and Intellectual Disabilities, Ibaraki, Japan. 9. Department of Pathology, Kitasato University Hospital, Sagamihara, Japan. 10. Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan. 11. Department of Diagnostic Pathology Division, Tokyo Medical University Hospital, Tokyo, Japan. 12. Department of Diagnostic Pathology and Cytology, Osaka International Cancer Institute, Osaka, Japan. 13. Department of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan. 14. Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan. 15. Department of Thoracic Surgery, Kitasato University School of Medicine, Sagamihara, Japan.
Abstract
INTRODUCTION: The classification of lung carcinoma is based on small biopsies and/or cytology in 80% of patients with non-small cell carcinoma. However, there is no widely accepted classification system for respiratory cytology. The Japan Lung Cancer Society (JLCS) and Japanese Society of Clinical Cytology (JSCC) have proposed a new four-tiered cytology reporting system for lung carcinoma with the following categories: (1) "negative for malignancy," (2) "atypical cells," (3) "suspicious for malignancy," and (4) "malignancy." OBJECTIVE: The aim of this work was to perform an interobserver reproducibility study to confirm the utility of the four-tiered reporting system on respiratory cytological samples. METHODS: We analyzed 90 cytological samples obtained with bronchoscopy. Seven observers classified these cases into each category by reviewing one Papanicolaou-stained slide per case according to the three-, four-, and five-tiered reporting systems. RESULTS: The interobserver agreement was fair in the three- (κ = 0.50), four- (κ = 0.45), and five-tiered (κ = 0.45) reporting systems. However, the four-tiered reporting system provided more precise information than the three-tiered reporting system in patient management. The risk of malignancy in the four-tiered reporting system was also stratified well: 19.3% for "negative for malignancy," 45.6% for "atypical cells," 74.7% for "suspicious for malignancy," and 88.1% for "malignancy." CONCLUSIONS: The reporting system proposed by the JLCS and JSCC was designed to enhance the communication between clinicians and pathologists and among different institutions. It is simple and applicable to cytological diagnosis of any respiratory diseases. We propose establishing an international classification for respiratory cytology, harmonizing the reporting systems proposed by different countries.
INTRODUCTION: The classification of lung carcinoma is based on small biopsies and/or cytology in 80% of patients with non-small cell carcinoma. However, there is no widely accepted classification system for respiratory cytology. The Japan Lung Cancer Society (JLCS) and Japanese Society of Clinical Cytology (JSCC) have proposed a new four-tiered cytology reporting system for lung carcinoma with the following categories: (1) "negative for malignancy," (2) "atypical cells," (3) "suspicious for malignancy," and (4) "malignancy." OBJECTIVE: The aim of this work was to perform an interobserver reproducibility study to confirm the utility of the four-tiered reporting system on respiratory cytological samples. METHODS: We analyzed 90 cytological samples obtained with bronchoscopy. Seven observers classified these cases into each category by reviewing one Papanicolaou-stained slide per case according to the three-, four-, and five-tiered reporting systems. RESULTS: The interobserver agreement was fair in the three- (κ = 0.50), four- (κ = 0.45), and five-tiered (κ = 0.45) reporting systems. However, the four-tiered reporting system provided more precise information than the three-tiered reporting system in patient management. The risk of malignancy in the four-tiered reporting system was also stratified well: 19.3% for "negative for malignancy," 45.6% for "atypical cells," 74.7% for "suspicious for malignancy," and 88.1% for "malignancy." CONCLUSIONS: The reporting system proposed by the JLCS and JSCC was designed to enhance the communication between clinicians and pathologists and among different institutions. It is simple and applicable to cytological diagnosis of any respiratory diseases. We propose establishing an international classification for respiratory cytology, harmonizing the reporting systems proposed by different countries.
Authors: Esther Diana Rossi; William C Faquin; Zubair Baloch; Güliz A Barkan; Maria Pia Foschini; Marc Pusztaszeri; Philippe Vielh; Daniel F I Kurtycz Journal: Cancer Cytopathol Date: 2017-07-14 Impact factor: 5.284
Authors: Andrew S Field; Wendy A Raymond; Mary Rickard; Lauren Arnold; Elena F Brachtel; Benjaporn Chaiwun; Lan Chen; Luigi Di Bonito; Daniel F I Kurtycz; Andrew H S Lee; Elgene Lim; Britt-Marie Ljung; Pamela Michelow; Robert Y Osamura; Maurizio Pinamonti; Torill Sauer; Davendra Segara; Gary Tse; Philippe Vielh; Phek Y Chong; Fernando Schmitt Journal: Acta Cytol Date: 2019-05-21 Impact factor: 2.319
Authors: Güliz A Barkan; Eva M Wojcik; Ritu Nayar; Spasenija Savic-Prince; Marcus L Quek; Daniel F I Kurtycz; Dorothy L Rosenthal Journal: Acta Cytol Date: 2016-06-18 Impact factor: 2.319