Chun-Hong Shen1, Yang Zheng1, Meng-Ting Cai2, Fan Yang1, Wei Fang3, Yin-Xi Zhang4, Mei-Ping Ding5. 1. Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. 2. Department of Neurology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, China. 3. Department of Neurology, Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Yiwu, China. 4. Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. Electronic address: zyx-neurology@zju.edu.cn. 5. Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. Electronic address: dmp-neurology@zju.edu.cn.
Abstract
OBJECTIVE: Recent reports have suggested that seizures may be a component of the clinical presentation in myelin oligodendrocyte glycoprotein antibody (MOG-Ab)-associated disease. We aimed to conduct a systematic review and meta-analysis to comprehensively evaluate the occurrence of epileptic seizures in the disease. METHODS: We searched PubMed, MEDLINE and EMBASE for studies reporting the occurrence of acute symptomatic seizures in MOG-Ab-associated disease. Fixed or random effects model was used to pool results across studies with a meta-analysis. RESULTS: A total of 14 studies met the inclusion criteria. Overall, acute symptomatic seizures were observed in 20.5% (95% confidence interval [CI] 13.7%-30.7%, I2=60.6%) patients with MOG-Ab-associated disease, and in a similar proportion of children respectively (20.0%; 95% CI 14.3%-27.8%, I2=7.0%). The pooled probability of seizure occurrence in males was 30.1% (95% CI 17.5%-52%, I2=0.0%) while that in females was much lower (12.0%; 95% CI 5.5%-26.4%, I2=0.0%). Furthermore, when we focused on those with acute disseminated encephalomyelitis-like phenotype, 37.3% patients experienced seizures (95% CI 21.0%-66.3%, I2=55.8%). CONCLUSIONS: Our study suggested that epileptic seizures were common in MOG-Ab-associated disease and offered insight into associated factors that contribute to the occurrence of seizures. Future studies with explicit evaluation are required.
OBJECTIVE: Recent reports have suggested that seizures may be a component of the clinical presentation in myelin oligodendrocyte glycoprotein antibody (MOG-Ab)-associated disease. We aimed to conduct a systematic review and meta-analysis to comprehensively evaluate the occurrence of epilepticseizures in the disease. METHODS: We searched PubMed, MEDLINE and EMBASE for studies reporting the occurrence of acute symptomatic seizures in MOG-Ab-associated disease. Fixed or random effects model was used to pool results across studies with a meta-analysis. RESULTS: A total of 14 studies met the inclusion criteria. Overall, acute symptomatic seizures were observed in 20.5% (95% confidence interval [CI] 13.7%-30.7%, I2=60.6%) patients with MOG-Ab-associated disease, and in a similar proportion of children respectively (20.0%; 95% CI 14.3%-27.8%, I2=7.0%). The pooled probability of seizure occurrence in males was 30.1% (95% CI 17.5%-52%, I2=0.0%) while that in females was much lower (12.0%; 95% CI 5.5%-26.4%, I2=0.0%). Furthermore, when we focused on those with acute disseminated encephalomyelitis-like phenotype, 37.3% patients experienced seizures (95% CI 21.0%-66.3%, I2=55.8%). CONCLUSIONS: Our study suggested that epilepticseizures were common in MOG-Ab-associated disease and offered insight into associated factors that contribute to the occurrence of seizures. Future studies with explicit evaluation are required.
Authors: María José Aguilar-Castillo; Pablo Cabezudo-García; Nicolas Lundahl Ciano-Petersen; Guillermina García-Martin; Marta Marín-Gracia; Guillermo Estivill-Torrús; Pedro Jesús Serrano-Castro Journal: Biomedicines Date: 2022-03-19