| Literature DB >> 32222542 |
Helong Quan1, Erika Koltai2, Katsuhiko Suzuki3, Aderbal S Aguiar4, Ricardo Pinho5, Istvan Boldogh6, Istvan Berkes2, Zsolt Radak7.
Abstract
Regular exercise induces a wide range of redox system-associated molecular adaptive responses to the nervous system. The intermittent induction of reactive oxygen species (ROS) during acute exercise sessions and the related upregulation of antioxidant/repair and housekeeping systems are associated with improved physiological function. Exercise-induced proliferation and differentiation of neuronal stem cells are ROS dependent processes. The increased production of brain derived neurotrophic factor (BDNF) and the regulation by regular exercise are dependent upon redox sensitive pathways. ROS are causative and associative factors of neurodegenerative diseases and regular exercise provides significant neuroprotective effects against Alzheimer's disease, Parkinson's disease, and hypoxia/reperfusion related disorders. Regular exercise regulates redox homeostasis in the brain with complex multi-level molecular pathways.Entities:
Keywords: Alzheimer diseases; Brain function; Exercise; Ischemia reperfusion; Neuroprotection; Parkinson's disease; Redox homeostasis
Mesh：
Substances：
Year: 2020 PMID： 32222542 DOI： 10.1016/j.bbadis.2020.165778
Source DB: PubMed Journal: Biochim Biophys Acta Mol Basis Dis ISSN： 0925-4439 Impact factor: 5.187