Alice C Verticchio Vercellin1,2,3, Alon Harris4, Lucia Tanga2, Brent Siesky3, Luciano Quaranta1, Lucas W Rowe5, Rana Torabi5, Luca Agnifili6, Ivano Riva2, Francesco Oddone2. 1. Department of Ophthalmology, University of Pavia, Pavia, Italy. 2. IRCCS - Fondazione Bietti, Rome, Italy. 3. Department of Ophthalmology, Ophthalmic Vascular Diagnostic and Research Program at Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, Annenberg 22-86, New York, NY, 10029, USA. 4. Department of Ophthalmology, Ophthalmic Vascular Diagnostic and Research Program at Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, Annenberg 22-86, New York, NY, 10029, USA. palonharris@gmail.com. 5. Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA. 6. Ophthalmology Clinic, Department of Medicine and Aging Science, University G. d'Annunzio of Chieti-Pescara, Chieti, Italy.
Abstract
BACKGROUND/AIMS: To evaluate diurnal variations in optic nerve head (ONH) vessel density assessed by optical coherence tomography angiography (OCT-A) in healthy subjects, ocular hypertension (OHT), and open-angle glaucoma (OAG) patients. METHODS: Forty subjects (OAG, 21; OHT, 6; healthy, 13) were assessed for vessel density percentage (VD%) and flow index in the ONH (NH VD%, NH index), and in the radial peripapillary capillary layer (RPC VD%, RPC index) at 9:00, 11:00, 14:00, 16:00, and 18:00 on a single day. Repeated measures ANOVAs were used to test for changes in the parameters measured at multiple time points. RESULTS: All OCT-A parameters analyzed at the different time points were statistically lower in the OAG patients compared to both the OHT and healthy groups (p < 0.05). In the OAG group, the NH index, RPC index, NH VD%, and RPC VD% were statistically lower at 18:00 compared to 14:00, and the RPC VD% was statistically lower at 9:00 than 14:00. In the OHT group, the RPC index was statistically lower at 9:00 than 11:00. In the healthy group, the NH VD% and RPC VD% were statistically lower at 16:00 than 18:00, and the RPC index was statistically lower at 9:00 than 11:00. No other statistically significant difference was found in none of the three groups comparing any other time point (p > 0.05). CONCLUSION: In healthy subjects, OHT and OAG patients, the variations in the OCT-A derived parameters were relatively small. These results suggest that in the clinical practice the OCT-A assessment can be performed independently of the time of the day, contrasting IOP evaluation.
BACKGROUND/AIMS: To evaluate diurnal variations in optic nerve head (ONH) vessel density assessed by optical coherence tomography angiography (OCT-A) in healthy subjects, ocular hypertension (OHT), and open-angle glaucoma (OAG) patients. METHODS: Forty subjects (OAG, 21; OHT, 6; healthy, 13) were assessed for vessel density percentage (VD%) and flow index in the ONH (NH VD%, NH index), and in the radial peripapillary capillary layer (RPC VD%, RPC index) at 9:00, 11:00, 14:00, 16:00, and 18:00 on a single day. Repeated measures ANOVAs were used to test for changes in the parameters measured at multiple time points. RESULTS: All OCT-A parameters analyzed at the different time points were statistically lower in the OAGpatients compared to both the OHT and healthy groups (p < 0.05). In the OAG group, the NH index, RPC index, NH VD%, and RPC VD% were statistically lower at 18:00 compared to 14:00, and the RPC VD% was statistically lower at 9:00 than 14:00. In the OHT group, the RPC index was statistically lower at 9:00 than 11:00. In the healthy group, the NH VD% and RPC VD% were statistically lower at 16:00 than 18:00, and the RPC index was statistically lower at 9:00 than 11:00. No other statistically significant difference was found in none of the three groups comparing any other time point (p > 0.05). CONCLUSION: In healthy subjects, OHT and OAGpatients, the variations in the OCT-A derived parameters were relatively small. These results suggest that in the clinical practice the OCT-A assessment can be performed independently of the time of the day, contrasting IOP evaluation.
Authors: Joshua D Shin; Amber T Wolf; Alon Harris; Alice Verticchio Vercellin; Brent Siesky; Lucas W Rowe; Michelle Packles; Francesco Oddone Journal: Acta Ophthalmol Date: 2021-08-06 Impact factor: 3.761
Authors: Jo-Hsuan Wu; Rafaella C Penteado; Sasan Moghimi; Linda M Zangwill; James A Proudfoot; Robert N Weinreb Journal: J Glaucoma Date: 2021-09-01 Impact factor: 2.290