Michael Darmon1,2, Eric Hoste3,4, Miet Schetz5. 1. Medical Intensive Care Unit, APHP, Hôpital Saint-Louis, 1 Avenue Claude Vellefaux, 75010, Paris, France. michael.darmon@aphp.fr. 2. ECSTRA Team, UMR 1153, Center of Epidemiology and Biostatistics, INSERM, Université de Paris, Paris, France. michael.darmon@aphp.fr. 3. Department of Intensive Care Medicine, Ghent University Hospital, Ghent University, C. Heymanslaan 10, 9000, Ghent, Belgium. 4. Research Foundation-Flanders (FWO), Brussels, Belgium. 5. Clinical Department and Laboratory of Intensive Care Medicine, Division of Cellular and Molecular Medicine, KU Leuven University, Herestraat 49, B3000, Louvain, Belgium.