| Literature DB >> 32221169 |
Nigel J Wilson1, Anthony Concannon2,3, John Malcolm4, Sarka Davidakova5, William John Martin6, Rachel Webb3,7,8, Nicole J Moreland9.
Abstract
Hydroxychloroquine (HCQ) suppresses an interleukin-1β-granulocyte-macrophage colony-stimulating factor cytokine axis, reported to be dysregulated in peripheral blood mononuclear cells of acute rheumatic fever patients ex vivo. We describe HCQ treatment for 2 patients with rheumatic carditis and a protracted inflammatory course. HCQ was associated with control of inflammatory markers, control of pericarditis in first patient and stabilization of progressive carditis in the second patient.Entities:
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Year: 2020 PMID： 32221169 DOI： 10.1097/INF.0000000000002647
Source DB: PubMed Journal: Pediatr Infect Dis J ISSN： 0891-3668 Impact factor: 2.129