| Literature DB >> 32220541 |
Xin Liang1, Wei Guo2, Tingting Ren1, Yi Huang1, Kunkun Sun3, Hongliang Zhang1, Yiyang Yu1, Wei Wang1, Jianfang Niu1.
Abstract
Osteosarcoma is a common, highly malignant tumor of the musculoskeletal system in young people. Compared with simple amputation in the past, the application of neoadjuvant chemotherapy significantly improved the 5-year survival rate and limb-salvage rate of tumor patients without metastasis. However, the survival rate of patients with metastatic disease treated with neoadjuvant chemotherapy has remained stagnant over the past 30 years despite repeated attempts of adding neoadjuvant chemotherapy agents into the regimen or enhancing the chemotherapy drug dose. In this study, we revealed that macrophages, stimulated by neoadjuvant chemotherapy agents, could reduce the sensitivity of osteosarcoma cells to the drugs. Furthermore, we found that this phenomenon was strongly related to the secretion of the interleukin-1beta by macrophages. Our findings may provide new ideas for improving the efficiency of neoadjuvant chemotherapy for osteosarcoma.Entities:
Keywords: Drug sensitivity; Interleukin-1 beta; Neoadjuvant chemotherapy; Tumor-associated inflammatory environment
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Year: 2020 PMID： 32220541 DOI： 10.1016/j.canlet.2020.03.019
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679