Wenjun Xie1, Xiaoyu Zhang2, Jiao Wang3, Jinghui Zhang1, Jie Liu1, Bei Wang1, Wei Guan1, Huijuan Zhang1, Li Xu1, Guiying Liu1, Sizhou Feng2, Changping Li3, Mingzhe Han4. 1. Department of Nursing Care, Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin, 300020, China. 2. Department of Hematopoietic Stem Cell Transplantation, Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, 288 Nanjing Road, Tianjin, 300020, China. 3. School of Public Health, Tianjin Medical University, Tianjin, 300070, China. 4. Department of Hematopoietic Stem Cell Transplantation, Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, 288 Nanjing Road, Tianjin, 300020, China. mzhan@ihcams.com.cn.
Abstract
PURPOSE: The aim of this study is to clarify the short-term quality of life (QoL) of acute leukemia (AL) patients early after stem cell transplantation (SCT) and related predictors of QoL recovery. METHODS: We investigated adult AL patients who underwent SCT at the Institute of Hematology and Blood Diseases Hospital after transplantation. Physical/functional and emotional/mental recovery were evaluated using the Short Form 36 (SF-36) questionnaire to identify its trajectory as well as related predictors for the physical component summary (PCS) and mental component summary (MCS). The score was also used to establish a QoL prediction model. RESULTS: A total of 326 AL patients responded to our QoL survey. The results revealed the profile of patient follow-up from 2013 to 2015. Along follow-up after transplantation, there was a significant increase in PCS (p = 0.139) and MCS (p = 0.122). On multivariate regression analysis, apart from follow-up, marriage, financial situation, employment situation, and history of chronic graft-versus-host disease (cGVHD) had clinical significance for both PCS and MCS. A prediction model for patient risk hierarchy estimation was further established. The logistic results revealed that the significant characteristics of patients with high PCS and high MCS were unmarried, without financial burden, reliable on drugs, and with history of acute graft-versus-host disease (aGVHD). CONCLUSIONS: This well-established study enabled evaluation of the QoL of AL patients post-HSCT in China. The established prediction model could provide more indications and insights into improvement in quality of life for better medical interventions.
PURPOSE: The aim of this study is to clarify the short-term quality of life (QoL) of acute leukemia (AL) patients early after stem cell transplantation (SCT) and related predictors of QoL recovery. METHODS: We investigated adult ALpatients who underwent SCT at the Institute of Hematology and Blood Diseases Hospital after transplantation. Physical/functional and emotional/mental recovery were evaluated using the Short Form 36 (SF-36) questionnaire to identify its trajectory as well as related predictors for the physical component summary (PCS) and mental component summary (MCS). The score was also used to establish a QoL prediction model. RESULTS: A total of 326 ALpatients responded to our QoL survey. The results revealed the profile of patient follow-up from 2013 to 2015. Along follow-up after transplantation, there was a significant increase in PCS (p = 0.139) and MCS (p = 0.122). On multivariate regression analysis, apart from follow-up, marriage, financial situation, employment situation, and history of chronic graft-versus-host disease (cGVHD) had clinical significance for both PCS and MCS. A prediction model for patient risk hierarchy estimation was further established. The logistic results revealed that the significant characteristics of patients with high PCS and high MCS were unmarried, without financial burden, reliable on drugs, and with history of acute graft-versus-host disease (aGVHD). CONCLUSIONS: This well-established study enabled evaluation of the QoL of ALpatients post-HSCT in China. The established prediction model could provide more indications and insights into improvement in quality of life for better medical interventions.