| Literature DB >> 32218527 |
Tommy Tsan-Yuk Lam1,2, Na Jia3, Ya-Wei Zhang3, Marcus Ho-Hin Shum2, Jia-Fu Jiang3, Yi-Gang Tong4, Hua-Chen Zhu1,2, Yong-Xia Shi5, Xue-Bing Ni2, Yun-Shi Liao2, Wen-Juan Li4, Bao-Gui Jiang3, Wei Wei6, Ting-Ting Yuan3, Kui Zheng5, Xiao-Ming Cui3, Jie Li3, Guang-Qian Pei3, Xin Qiang3, William Yiu-Man Cheung2, Lian-Feng Li7, Fang-Fang Sun5, Si Qin3, Ji-Cheng Huang5, Gabriel M Leung2, Edward C Holmes8, Yan-Ling Hu9,10, Yi Guan11,12, Wu-Chun Cao13.
Abstract
The ongoing outbreak of viral pneumonia in China and across the world is associated with a new coronavirus, SARS-CoV-21. This outbreak has been tentatively associated with a seafood market in Wuhan, China, where the sale of wild animals may be the source of zoonotic infection2. Although bats are probable reservoir hosts for SARS-CoV-2, the identity of any intermediate host that may have facilitated transfer to humans is unknown. Here we report the identification of SARS-CoV-2-related coronaviruses in Malayan pangolins (Manis javanica) seized in anti-smuggling operations in southern China. Metagenomic sequencing identified pangolin-associated coronaviruses that belong to two sub-lineages of SARS-CoV-2-related coronaviruses, including one that exhibits strong similarity in the receptor-binding domain to SARS-CoV-2. The discovery of multiple lineages of pangolin coronavirus and their similarity to SARS-CoV-2 suggests that pangolins should be considered as possible hosts in the emergence of new coronaviruses and should be removed from wet markets to prevent zoonotic transmission.Entities:
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Year: 2020 PMID： 32218527 DOI： 10.1038/s41586-020-2169-0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962