Anna Waszczuk-Gajda1, Joanna Drozd-Sokołowska2, Grzegorz Władysław Basak2, Agnieszka Piekarska3, Patrycja Mensah-Glanowska4, Alicja Sadowska-Klasa3, Agnieszka Wierzbowska5, Piotr Rzepecki6, Agnieszka Tomaszewska7, Joanna Mańko8, Marek Hus8, Monika Adamska9, Joanna Romejko-Jarosińska10, Jarosław Dybko11, Monika Biernat11, Sławomira Kyrcz-Krzemień12, Mariola Sędzimirska13, Natalia Winciorek13, Wiesław Wiktor Jędrzejczak2, Jan Styczyński14, Sebastian Giebel15, Lidia Gil9. 1. Department of Hematology, Oncology, and Internal Medicine, Medical University of Warsaw, Poland. Electronic address: annawaszczukgajda@gmail.com. 2. Department of Hematology, Oncology, and Internal Medicine, Medical University of Warsaw, Poland. 3. Medical University of Gdansk, Gdansk, Poland. 4. Collegium Medicum, Jagiellonian University, Krakow, Poland. 5. Medical University of Lodz, Lodz, Poland. 6. Military Institute of Medicine, Department of Hematology, Warsaw, Poland. 7. Department of Hematology, Oncology, and Internal Medicine, Medical University of Warsaw, Poland; Institute of Hematology and Transfusion Medicine, Warsaw, Poland. 8. Medical University of Lublin, Lublin, Poland. 9. Poznan University of Medical Sciences, Poznan, Poland. 10. Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw Branch, Department of Lymphoid Diseases, Warsaw, Poland. 11. Wroclaw Medical University, Wroclaw, Poland. 12. Medical University of Silesia, Katowice, Poland. 13. Lower Silesian Center for Cellular Transplantation and National Bone Marrow Donor Bank, Wroclaw, Poland. 14. Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University Torun, Bydgoszcz. 15. Maria Sklodowska-Curie Institute Cancer Center, Gliwice Branch, Gliwice, Poland.
Abstract
BACKGROUND: Multiple myeloma (MM) has become a chronic disease in majority of patients, and remission consolidation with autologous hematopoietic stem cell transplant (ASCT) remains the backbone of treatment in transplant-eligible patients. OBJECTIVE: The aim of this multicenter cross-sectional nationwide retrospective study was to evaluate the epidemiology, etiology, and outcome of infections in patients with MM undergoing ASCT in 13 Polish transplant centers, carried out on behalf of the Infectious Complications Study Group of the Polish Adult Leukemia Group. METHODS: A total number of consecutive 1374 patients with MM treated in Polish adult transplant centers from 2012 to 2014 were followed for infectious complications up to day +100 after ASCT in nationwide study. RESULTS: Altogether 490 infection episodes in 336 patients (49% male, aged 21-72 years) were reported, including 145 episodes of neutropenic fever (103 patients) and 34 episodes of clinically documented infections (CDIs) (27 patients). Among microbiologically confirmed infections there were 251 episodes of bacterial infections (180 patients), 42 episodes of fungal infections (38 patients), and 18 episodes of viral infections (17 patients). The overall incidence of infections reached 13.1% for bacterial, 3.6% for fungal, and 1.3% for viral infections. There were 16 cases of infection-related deaths after ASCT (1.2%). The mortality risk factors included multidrug-resistant bacteria etiology (odds ratio [OR], 3.5; P = .033), coexistence of bacterial and fungal infection (OR, 6.3; P = .002), and CDI (OR, 5.5; P = .007). CONCLUSION: ASCT in patients with MM was connected with low risk of life-threatening infections. However, multidrug-resistant bacteria bacterial etiology, mixed etiology, and CDI increased the risk of fatal outcome.
BACKGROUND:Multiple myeloma (MM) has become a chronic disease in majority of patients, and remission consolidation with autologous hematopoietic stem cell transplant (ASCT) remains the backbone of treatment in transplant-eligible patients. OBJECTIVE: The aim of this multicenter cross-sectional nationwide retrospective study was to evaluate the epidemiology, etiology, and outcome of infections in patients with MM undergoing ASCT in 13 Polish transplant centers, carried out on behalf of the Infectious Complications Study Group of the Polish Adult Leukemia Group. METHODS: A total number of consecutive 1374 patients with MM treated in Polish adult transplant centers from 2012 to 2014 were followed for infectious complications up to day +100 after ASCT in nationwide study. RESULTS: Altogether 490 infection episodes in 336 patients (49% male, aged 21-72 years) were reported, including 145 episodes of neutropenic fever (103 patients) and 34 episodes of clinically documented infections (CDIs) (27 patients). Among microbiologically confirmed infections there were 251 episodes of bacterial infections (180 patients), 42 episodes of fungal infections (38 patients), and 18 episodes of viral infections (17 patients). The overall incidence of infections reached 13.1% for bacterial, 3.6% for fungal, and 1.3% for viral infections. There were 16 cases of infection-related deaths after ASCT (1.2%). The mortality risk factors included multidrug-resistant bacteria etiology (odds ratio [OR], 3.5; P = .033), coexistence of bacterial and fungal infection (OR, 6.3; P = .002), and CDI (OR, 5.5; P = .007). CONCLUSION: ASCT in patients with MM was connected with low risk of life-threatening infections. However, multidrug-resistant bacteria bacterial etiology, mixed etiology, and CDI increased the risk of fatal outcome.
Authors: Ajai Chari; Mehmet Kemal Samur; Joaquin Martinez-Lopez; Gordon Cook; Noa Biran; Kwee L Yong; Vania Tietsche de Moraes Hungria; Monika Engelhardt; Francesca Gay; Ana Garcia-Feria; Stefania Oliva; Rimke Oostvogels; Alessandro Gozzetti; Cara A Rosenbaum; Shaji K Kumar; Edward Stadtmauer; Hermann Einsele; Meral Beksac; Katja C Weisel; Kenneth C Anderson; Maria-Victoria Mateos; Philippe Moreau; Jesús San Miguel; Nikhil C Munshi; Hervé Avet-Loiseau Journal: Blood Date: 2020-11-06 Impact factor: 22.113
Authors: Anna Waszczuk-Gajda; Olaf Penack; Giulia Sbianchi; Linda Koster; Didier Blaise; Péter Reményi; Nigel Russell; Per Ljungman; Marek Trneny; Jiri Mayer; Simona Iacobelli; Guido Kobbe; Christof Scheid; Jane Apperley; Cyrille Touzeau; Stig Lenhoff; Esa Jantunen; Achilles Anagnostopoulos; Laura Paris; Paul Browne; Catherine Thieblemont; Nicolaas Schaap; Jorge Sierra; Ibrahim Yakoub-Agha; Laurent Garderet; Jan Styczynski; Helene Schoemans; Ivan Moiseev; Rafael F Duarte; Zinaida Peric; Silvia Montoto; Anja van Biezen; Malgorzata Mikulska; Mahmoud Aljurf; Tapani Ruutu; Nicolaus Kröger; Curly Morris; Christian Koenecke; Stefan Schoenland; Grzegorz W Basak Journal: J Clin Med Date: 2022-06-20 Impact factor: 4.964
Authors: Ajai Chari; Mehmet Kemal Samur; Joaquin Martinez-Lopez; Gordon Cook; Noa Biran; Kwee Yong; Vania Hungria; Monika Engelhardt; Francesca Gay; Ana García Feria; Stefania Oliva; Rimke Oostvogels; Alessandro Gozzetti; Cara Rosenbaum; Shaji Kumar; Edward A Stadtmauer; Hermann Einsele; Meral Beksac; Katja Weisel; Kenneth C Anderson; María-Victoria Mateos; Philippe Moreau; Jesus San-Miguel; Nikhil C Munshi; Hervé Avet-Loiseau Journal: Blood Date: 2020-12-24 Impact factor: 22.113