Literature DB >> 32216675

Gut bacteria affect the tumoral immune milieu: distorting the efficacy of immunotherapy or not？.

Pu Xiaoyu1, Ge Chao1, Dong Lihua1,2, Chang Pengyu1,3.   

Abstract

Immunotherapy using immune-checkpoint inhibitors is revolutionizing oncotherapy. However, the application of immunotherapy may be restricted because of the lack of proper biomarkers in a portion of cancer patients. Recently, emerging evidence has revealed that gut commensal bacteria can impact the therapeutic efficacy of immune-checkpoint inhibitors in several cancer models. In addition, testing the composition of gut bacteria provides context for prediction of the efficacy and toxicity of immunotherapy. In this review, we discuss the impacts of gut commensal bacteria on the tumoral immune milieu, highlighting some typical bacteria and their associations with immunotherapy.

Entities:  

Keywords:  Commensal bacteria; gut immunity; immune-checkpoint inhibitor; immunotherapy biomarker; tumor immune milieu

Year:  2020        PMID： 32216675      PMCID： PMC7524336          DOI： 10.1080/19490976.2020.1739794

Source DB:  PubMed          Journal:  Gut Microbes        ISSN： 1949-0976


  112 in total

1.  Effects of Bifidobacterium supplementation on intestinal microbiota composition and the immune response in healthy infants.

Authors:  Bing-Bing Wu; Yi Yang; Xiu Xu; Wei-Ping Wang
Journal:  World J Pediatr       Date:  2015-04-06       Impact factor: 2.764

Review 2.  Intestinal epithelial cells: regulators of barrier function and immune homeostasis.

Authors:  Lance W Peterson; David Artis
Journal:  Nat Rev Immunol       Date:  2014-03       Impact factor: 53.106

3.  A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice.

Authors:  Hubert Plovier; Amandine Everard; Céline Druart; Clara Depommier; Matthias Van Hul; Lucie Geurts; Julien Chilloux; Noora Ottman; Thibaut Duparc; Laeticia Lichtenstein; Antonis Myridakis; Nathalie M Delzenne; Judith Klievink; Arnab Bhattacharjee; Kees C H van der Ark; Steven Aalvink; Laurent O Martinez; Marc-Emmanuel Dumas; Dominique Maiter; Audrey Loumaye; Michel P Hermans; Jean-Paul Thissen; Clara Belzer; Willem M de Vos; Patrice D Cani
Journal:  Nat Med       Date:  2016-11-28       Impact factor: 53.440

4.  Daily Sampling Reveals Personalized Diet-Microbiome Associations in Humans.

Authors:  Abigail J Johnson; Pajau Vangay; Gabriel A Al-Ghalith; Benjamin M Hillmann; Tonya L Ward; Robin R Shields-Cutler; Austin D Kim; Anna Konstantinovna Shmagel; Arzang N Syed; Jens Walter; Ravi Menon; Katie Koecher; Dan Knights
Journal:  Cell Host Microbe       Date:  2019-06-12       Impact factor: 21.023

Review 5.  Emerging biomarkers for immune checkpoint inhibition in lung cancer.

Authors:  George Cyriac; Leena Gandhi
Journal:  Semin Cancer Biol       Date:  2018-05-19       Impact factor: 15.707

6.  The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression.

Authors:  Smruti Pushalkar; Mautin Hundeyin; Donnele Daley; Constantinos P Zambirinis; Emma Kurz; Ankita Mishra; Navyatha Mohan; Berk Aykut; Mykhaylo Usyk; Luisana E Torres; Gregor Werba; Kevin Zhang; Yuqi Guo; Qianhao Li; Neha Akkad; Sarah Lall; Benjamin Wadowski; Johana Gutierrez; Juan Andres Kochen Rossi; Jeremy W Herzog; Brian Diskin; Alejandro Torres-Hernandez; Josh Leinwand; Wei Wang; Pardeep S Taunk; Shivraj Savadkar; Malvin Janal; Anjana Saxena; Xin Li; Deirdre Cohen; R Balfour Sartor; Deepak Saxena; George Miller
Journal:  Cancer Discov       Date:  2018-03-22       Impact factor: 39.397

7.  Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice.

Authors:  Tze Guan Tan; Esen Sefik; Naama Geva-Zatorsky; Lindsay Kua; Debdut Naskar; Fei Teng; Lesley Pasman; Adriana Ortiz-Lopez; Ray Jupp; Hsin-Jung Joyce Wu; Dennis L Kasper; Christophe Benoist; Diane Mathis
Journal:  Proc Natl Acad Sci U S A       Date:  2016-11-23       Impact factor: 11.205

8.  Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab.

Authors:  N Chaput; P Lepage; C Coutzac; E Soularue; K Le Roux; C Monot; L Boselli; E Routier; L Cassard; M Collins; T Vaysse; L Marthey; A Eggermont; V Asvatourian; E Lanoy; C Mateus; C Robert; F Carbonnel
Journal:  Ann Oncol       Date:  2017-06-01       Impact factor: 32.976

9.  Environmental and gut bacteroidetes: the food connection.

Authors:  François Thomas; Jan-Hendrik Hehemann; Etienne Rebuffet; Mirjam Czjzek; Gurvan Michel
Journal:  Front Microbiol       Date:  2011-05-30       Impact factor: 5.640

10.  Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine.

Authors:  Ivaylo I Ivanov; Rosa de Llanos Frutos; Nicolas Manel; Keiji Yoshinaga; Daniel B Rifkin; R Balfour Sartor; B Brett Finlay; Dan R Littman
Journal:  Cell Host Microbe       Date:  2008-10-16       Impact factor: 21.023
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  1 in total

Review 1.  The Role of Gut Microbiota in Tumor Immunotherapy.

Authors:  Miao Wu; Jiawei Bai; Chengtai Ma; Jie Wei; Xianjin Du
Journal:  J Immunol Res       Date:  2021-08-26       Impact factor: 4.818
  1 in total

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