Xiaoyong Guo1,2,3,4, Zhao He5,6, Shanshan Shao1,3,4, Yilin Fu1,3,4, Dongmei Zheng1,3,4, Lu Liu1, Ling Gao3,4,7, Liying Guan8, Meng Zhao9,10,11, Jiajun Zhao12,13,14. 1. Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China. 2. Department of Endocrinology, The Second affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia, China. 3. Institute of Endocrinology and metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China. 4. Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, Shandong, China. 5. Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, China. 6. School of Medicine, Shandong University, Jinan, Shandong, China. 7. Scientific Center, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China. 8. Health Management Center, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China. Liliguansun001@163.com. 9. Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China. zjsylpzm@163.com. 10. Institute of Endocrinology and metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China. zjsylpzm@163.com. 11. Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, Shandong, China. zjsylpzm@163.com. 12. Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China. jjzhao@sdu.edu.cn. 13. Institute of Endocrinology and metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China. jjzhao@sdu.edu.cn. 14. Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, Shandong, China. jjzhao@sdu.edu.cn.
Abstract
PURPOSE: The role of thyroid autoimmunity in the association between obesity and hyperthyrotropinaemia remains unclear. We aimed to assess the relationship between obesity, autoimmunity, and hyperthyrotropinaemia. METHODS: In this population-based cross-sectional study, 12531 Chinese individuals (18-80 years) with thyroid function test were categorized into three groups by body mass index (BMI) and were categorized into three layers by thyroid autoantibodies. Multivariate logistic regression was employed to assess the correlation and interaction effect. RESULTS: There was no significant difference in prevalence of hyperthyrotropinaemia (P = 0.637) among three BMI groups. After stratification, the difference of serum thyrotropin (P < 0.01) and prevalence of hyperthyrotropinaemia (P < 0.01) between the three groups have significant linear trends at the positive levels of thyroid peroxidase antibody (TPOAb) or/and thyroglobulin antibody (TgAb). When TPOAb and TgAb were positive, the risk of hyperthyrotropinaemia increased 1.857-fold in overweight group and 2.201-fold in obese group compared with normal group. Compared with negative TPOAb and TgAb, the risk of hyperthyrotropinaemia for individuals with two positive antibodies increased 3.310-fold, 4.969-fold, and 5.122-fold in the three BMI groups. The adjusted OR (95% CI) for interaction were 1.033 (0.752-1.419) for overweight and one positive antibodies, 1.935 (1.252-2.990) for overweight and two positive antibodies, 1.435 (0.978-2.105) for obesity and one positive antibodies and 2.191 (1.252-3.832) for obesity and two positive antibodies. CONCLUSION: Overweight and obesity were associated with hyperthyrotropinaemia only in presence of thyroid autoimmunity, and obesity might aggravate the pathogenic effect of autoimmunity on hyperthyrotropinaemia. There was an interaction effect between obesity and autoimmunity on the prevalence of hyperthyrotropinaemia.
PURPOSE: The role of thyroid autoimmunity in the association between obesity and hyperthyrotropinaemia remains unclear. We aimed to assess the relationship between obesity, autoimmunity, and hyperthyrotropinaemia. METHODS: In this population-based cross-sectional study, 12531 Chinese individuals (18-80 years) with thyroid function test were categorized into three groups by body mass index (BMI) and were categorized into three layers by thyroid autoantibodies. Multivariate logistic regression was employed to assess the correlation and interaction effect. RESULTS: There was no significant difference in prevalence of hyperthyrotropinaemia (P = 0.637) among three BMI groups. After stratification, the difference of serum thyrotropin (P < 0.01) and prevalence of hyperthyrotropinaemia (P < 0.01) between the three groups have significant linear trends at the positive levels of thyroid peroxidase antibody (TPOAb) or/and thyroglobulin antibody (TgAb). When TPOAb and TgAb were positive, the risk of hyperthyrotropinaemia increased 1.857-fold in overweight group and 2.201-fold in obese group compared with normal group. Compared with negative TPOAb and TgAb, the risk of hyperthyrotropinaemia for individuals with two positive antibodies increased 3.310-fold, 4.969-fold, and 5.122-fold in the three BMI groups. The adjusted OR (95% CI) for interaction were 1.033 (0.752-1.419) for overweight and one positive antibodies, 1.935 (1.252-2.990) for overweight and two positive antibodies, 1.435 (0.978-2.105) for obesity and one positive antibodies and 2.191 (1.252-3.832) for obesity and two positive antibodies. CONCLUSION: Overweight and obesity were associated with hyperthyrotropinaemia only in presence of thyroid autoimmunity, and obesity might aggravate the pathogenic effect of autoimmunity on hyperthyrotropinaemia. There was an interaction effect between obesity and autoimmunity on the prevalence of hyperthyrotropinaemia.
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