Healthy people 2100: modeling population health impacts of climate change.

Quantitatively estimating the potential health impacts of climate change is facilitated by multi-determinant models that integrate micro- to macro-level exposures and processes that influence disease occurrence, including the public health responses, in order to identify regions and population groups that may be more vulnerable. Although progress has been made in constructing systems-based models, considerable work is required to address key issues of quantification of the climate-health associations and the factors that affect those associations; specification of model(s) appropriate to incorporate climate change, adaptation, and mitigation policies; incorporation of thresholds; incorporation of pathways of public health development; and quantification of uncertainties. © Springer Science+Business Media, B.V. 2007.