| Literature DB >> 322123 |
V G Baranov, M E Kogan, M V Propp, F I Proimina.
Abstract
In the androgen-sterile rats given 10-250 mug of testosterone-propionate there was observed at the early postnatal period a reduction in the LH-RP level in the hypothalamus, of the LH in the hypophysis and the blood, of the weight of the ovaries and of the corporal luteum count in them, as well as an increase in the dopamine level in the anterior portion of the hypothalamus. Klomiphen administration for 5 days in a dose of 20 mug led to the normalization of these indices and to the appearance of ovulation, but failed to restore the capacity to pregnancy. Prolonged klomiphen administration (20 mug every 3 days for a period of 1 month) also failed to restore this capacity.Entities:
Keywords: Amines; Androgens; Animals, Laboratory; Biology; Catecholamines--analysis; Central Nervous System; Clinical Research; Clomiphene--administraction and dosage; Clomiphene--side effects; Comparative Studies; Corpus Luteum; Endocrine System; Family Planning; Fertility Agents; Genitalia; Genitalia, Female; Gonadotropins; Gonadotropins, Pituitary; Hormones; Hypothalamus; Ingredients And Chemicals; Luteinizing Hormone--analysis; Organic Chemicals; Ovarian Effects; Ovary; Physiology; Pituitary Hormone Releasing Hormones--analysis; Reproductive Control Agents; Research Methodology; Reversibility; Studies; Testosterone--administraction and dosage; Testosterone--side effects; Urogenital System
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Year: 1977 PMID： 322123
Source DB: PubMed Journal: Probl Endokrinol (Mosk) ISSN： 0375-9660