Babatunde Y Alli1, Robert D Burk2,3,4,5, Mahnaz Fatahzadeh6, Julie Kazimiroff7, Robert M Grossberg8, Richard V Smith9, Thomas J Ow9,10, Mauricio Wiltz7, Jacqueline Polanco7, Marie-Claude Rousseau1,11, Belinda Nicolau1, Nicolas F Schlecht1,5,10,12. 1. Faculty of Dentistry, McGill University, Montreal, Canada. 2. Departments of Pediatrics (Genetics), Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA. 3. Department of Microbiology and Immunology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA. 4. Department of Obstetrics Gynecology and Women's Health, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA. 5. Department of Epidemiology and Population Health, Albert Einstein College of Medicine and Montefiore Medical Center, New York, USA. 6. Department of Diagnostic Sciences, Rutgers School of Dental Medicine, Newark, New Jersey, USA. 7. Department of Dentistry, Albert Einstein College of Medicine and Montefiore Medical Center, New York, USA. 8. Department of Infectious Diseases, Albert Einstein College of Medicine and Montefiore Medical Center, New York, USA. 9. Department of Otorhinolaryngology-Head and Neck Surgery, Albert Einstein College of Medicine and Montefiore Medical Center, New York, USA. 10. Department of Pathology, Albert Einstein College of Medicine and Montefiore Medical Center, New York, USA. 11. Epidemiology and Biostatistics Unit, Centre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, Quebec, Canada. 12. Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.
Abstract
BACKGROUND: People living with HIV (PLWH) are more likely to smoke and harbor oral human papillomavirus (HPV) infections, putting them at higher risk for head and neck cancer. We investigated effects of HIV and smoking on oral HPV risk. METHODS: Consecutive PLWH (n = 169) and at-risk HIV-negative individuals (n = 126) were recruited from 2 US health centers. Smoking history was collected using questionnaires. Participants provided oral rinse samples for HPV genotyping. We used multivariable logistic regression models with interaction terms for HIV to test for smoking effect on oral HPV. RESULTS: PLWH were more likely to harbor oral HPV than HIV-negative individuals, including α (39% vs 28%), β (73% vs 63%), and γ-types (33% vs 20%). HIV infection positively modified the association between smoking and high-risk oral HPV: odds ratios for smoking 3.46 (95% confidence interval [CI], 1.01-11.94) and 1.59 (95% CI, .32-8.73) among PLWH and HIV-negative individuals, respectively, and relative excess risk due to interaction (RERI) 3.34 (95% CI, -1.51 to 8.18). RERI for HPV 16 was 1.79 (95% CI, -2.57 to 6.16) and 2.78 for β1-HPV (95% CI, -.08 to 5.65). CONCLUSION: Results show tobacco smoking as a risk factor for oral HPV among PLWH.
BACKGROUND:People living with HIV (PLWH) are more likely to smoke and harbor oral human papillomavirus (HPV) infections, putting them at higher risk for head and neck cancer. We investigated effects of HIV and smoking on oral HPV risk. METHODS: Consecutive PLWH (n = 169) and at-risk HIV-negative individuals (n = 126) were recruited from 2 US health centers. Smoking history was collected using questionnaires. Participants provided oral rinse samples for HPV genotyping. We used multivariable logistic regression models with interaction terms for HIV to test for smoking effect on oral HPV. RESULTS: PLWH were more likely to harbor oral HPV than HIV-negative individuals, including α (39% vs 28%), β (73% vs 63%), and γ-types (33% vs 20%). HIV infection positively modified the association between smoking and high-risk oral HPV: odds ratios for smoking 3.46 (95% confidence interval [CI], 1.01-11.94) and 1.59 (95% CI, .32-8.73) among PLWH and HIV-negative individuals, respectively, and relative excess risk due to interaction (RERI) 3.34 (95% CI, -1.51 to 8.18). RERI for HPV 16 was 1.79 (95% CI, -2.57 to 6.16) and 2.78 for β1-HPV (95% CI, -.08 to 5.65). CONCLUSION: Results show tobacco smoking as a risk factor for oral HPV among PLWH.
Authors: Maura L Gillison; Tatevik Broutian; Robert K L Pickard; Zhen-you Tong; Weihong Xiao; Lisa Kahle; Barry I Graubard; Anil K Chaturvedi Journal: JAMA Date: 2012-01-26 Impact factor: 56.272
Authors: Mirjam J Knol; Tyler J VanderWeele; Rolf H H Groenwold; Olaf H Klungel; Maroeska M Rovers; Diederick E Grobbee Journal: Eur J Epidemiol Date: 2011-02-23 Impact factor: 8.082
Authors: Ethel-Michele de Villiers; Claude Fauquet; Thomas R Broker; Hans-Ulrich Bernard; Harald zur Hausen Journal: Virology Date: 2004-06-20 Impact factor: 3.616
Authors: Claudia P Hernandez; Kevin Morrow; Cruz Velasco; Dorota D Wyczechowska; Amarjit S Naura; Paulo C Rodriguez Journal: Cell Immunol Date: 2013-04-22 Impact factor: 4.868
Authors: Ilir Agalliu; Susan Gapstur; Zigui Chen; Tao Wang; Rebecca L Anderson; Lauren Teras; Aimée R Kreimer; Richard B Hayes; Neal D Freedman; Robert D Burk Journal: JAMA Oncol Date: 2016-05-01 Impact factor: 31.777
Authors: James Riddell; Andrew F Brouwer; Heather M Walline; Lora P Campredon; Rafael Meza; Marisa C Eisenberg; Emily C Andrus; Rachel L Delinger; Monica L Yost; Jodi K McCloskey; Trey B Thomas; Suiyuan Huang; Robert L Ferris; Dong Moon Shin; Carole Fakhry; Thomas Ow; Daniel Li; Ashley Berlot; Thomas E Carey; Nicolas F Schlecht Journal: Tumour Virus Res Date: 2022-04-20