Understanding Patient Perspectives on Medication Adherence in Asthma: A Targeted Review of Qualitative Studies.

Adherence to asthma medications is generally poor and undermines clinical outcomes. Poor adherence is characterized by underuse of inhaled corticosteroids (ICS), often accompanied by over-reliance on short-acting β2-agonists for symptom relief. To identify drivers of poor medication adherence, a targeted literature search was performed in MEDLINE and EMBASE for articles presenting qualitative data evaluating medication adherence in asthma patients (≥12 years old), published from January 1, 2012 to February 26, 2018. A thematic analysis of 21 relevant articles revealed several key themes driving poor medication adherence, including asthma-specific drivers and more general drivers common to chronic diseases. Due to the episodic nature of asthma, many patients felt that their daily life was not substantially impacted; consequently, many harbored doubts about the accuracy of their diagnosis or were in denial about the impact of the disease and, in turn, the need for long-term treatment. This was further compounded by poor patient-physician communication, which contributed to suboptimal knowledge about asthma medications, including lack of understanding of the distinction between maintenance and reliever inhalers, suboptimal inhaler technique, and concerns about ICS side effects. Other drivers of poor medication adherence included the high cost of asthma medication, general forgetfulness, and embarrassment over inhaler use in public. Overall, patients' perceived lack of need for asthma medications and medication concerns, in part due to suboptimal knowledge and poor patient-physician communication, emerged as key drivers of poor medication adherence. Optimal asthma care and management should therefore target these barriers through effective patient- and physician-centered strategies.

Introduction

Asthma is a chronic inflammatory airway disease that affects approximately 339 million people worldwide.1 The Global Initiative for Asthma (GINA) recommends the use of inhaled corticosteroids (ICS) as maintenance therapy for patients with asthma and, until an update in 2019,2 short-acting β2-agonists (SABAs) for as-needed relief of asthma symptoms.3 However, despite the availability of effective treatment regimens, asthma remains uncontrolled in approximately 50% of patients who, therefore, remain at risk for potentially serious exacerbations.4,5

Poor medication adherence, either intentionally or unintentionally,6 is recognized as one of the main reasons for suboptimal asthma management and poor clinical outcomes,7 with evidence of widespread ICS underuse across the spectrum of asthma.8,9 Such patients often demonstrate over-reliance on SABAs for symptom relief,9 which is a concern since excessive use of SABAs may worsen asthma control and increase the risk of fatal or near-fatal asthma events.10–13 In parallel, underuse of maintenance ICS may increase the risk of exacerbations because the underlying inflammation is not addressed.14,15 The discordance between clinicians’ perceptions of patients’ medication adherence and actual medication adherence is also problematic,16 while the failure to recognize poor medication adherence16 or the factors leading to poor adherence17,18 can result in erroneous prescribing patterns and suboptimal asthma outcomes.

To better understand the underlying patient behavior driving medication adherence and patient-centered reasons for inappropriate use of SABAs and ICS, qualitative research may be ideally suited to discover subtleties and nuances from the patients’ perspective, which often cannot be gleaned from quantitative research alone. Thus, we sought to identify associated patterns and themes by conducting a targeted literature review of the qualitative evidence on medication adherence in patients with asthma, with specific regard to SABA and ICS use.

Methods

Data Source

A targeted literature review was conducted to identify qualitative evidence on adherence to prescribed asthma medications by performing systematic and reproducible literature searches. Searches were conducted in MEDLINE (via PubMed) and EMBASE for articles published in English from January 1, 2012 through February 26, 2018 (). This 6-year search period was chosen to ensure that the data captured would reflect the current status of medication adherence in the asthma treatment landscape.

Study Selection

Articles were selected through 2 levels of screening. At the abstract level, PICOS (population, intervention, comparison, outcome, and study design) criteria outlining the characteristics of studies to be selected for further review were applied (Table 1). Articles that presented observational and clinical study data evaluating medication adherence and associated outcomes in patients (≥12 years old) with asthma receiving licensed treatments, and from any geographical region, were included. At the full-text level, a senior investigator determined which articles provided the best evidence for inclusion.

Table 1

PICOS Criteria for Study Selection

Criteria	Inclusion Criteria
Population(s)	Persons aged ≥12 years with asthma
Interventions/comparators	Licensed treatments and/or complementary and alternative medicine
Outcomes	Medication initiation, implementation, and discontinuation
Study design	Qualitative research (prospective and retrospective studies,cross-sectional and longitudinal studies, systematic literature reviews, and clinical trials)
Other	English language, any geographical region

Abbreviation: PICOS, population, intervention, comparison, outcome, and study design.

In addition, 2 independent researchers evaluated the articles using the National Institute for Health and Care Excellence (NICE) quality appraisal checklist – qualitative studies,19 according to which articles were scored on the basis of their theoretical approach (whether the qualitative design was appropriate), study design, data collection method, trustworthiness, analysis, and ethics. Based on the checklist, articles were rated as “good,” “fair,” or “mixed.”

Data Analysis

Data extraction of the studies selected for the targeted review was performed using the data extraction template designed in Microsoft Word®. Data were captured from each included study by a single investigator and 50% of the data were validated by checking for accuracy and consistency in reporting by a second, more senior researcher. The extracted data were analyzed using a thematic analysis.20–22 This involved initial reading and rereading of the extracted data to identify themes relating to initiation, implementation (the quality of regimen execution), and discontinuation of asthma treatment regimens from the patient perspective, caregiver perspective (if available in the abstracted articles), or physician perspective (if available in the abstracted articles). If multiple perspectives were available (patient, caregiver, and physician), the results were triangulated with one another to identify similarities and differences. Five steps of the thematic analysis were executed: in-depth reading of each article, abstraction of the qualitative findings, initial coding of the abstracted qualitative findings, comparison and contrast of themes across the abstracted studies for further refinement, and final synthesis of data-driven themes. The abstracted data were initially assigned discrete conceptual labels that would break down the abstracted qualitative findings into descriptive qualitative themes. For example, findings that patients considered asthma medication as a pro re nata (prn) therapy may be initially given a “prn” code. As codes are added through iterative review of the abstracted articles, a final coding schema would emerge. The analysis was directed by the available data, whereby themes were developed through constant comparison of the similarities and differences in the abstracted qualitative data and both supportive and disconfirming evidence of the themes was identified.

Results

Targeted Search Results

Of the 254 citations identified in MEDLINE (via PubMed) and EMBASE, 21 relevant articles were included (Figure 1, and ). Of these, 14 were sourced from database searches. Additionally, 8 potential articles were identified from the reference lists of included articles. After undergoing screening for eligibility, 1 article was subsequently deemed ineligible and 7 were included in the analysis. A quality assessment was performed per the NICE appraisal checklist19 on all included articles. Overall, 9 studies23–31 were rated as “good,” 11 studies18,32–41 were rated as “fair,” and 1 study42 was rated as “mixed” by 2 independent researchers with good agreement.

Figure 1

Summary of study selection for analysis.

Characteristics of the included studies are summarized in . The studies were performed across 7 countries: United States (n=9), Canada and Australia (n=3 each), Sweden and the United Kingdom (n=2 each), and Germany and the Netherlands (n=1 each). Most studies (57% [n=12]) focused on adults, while 19% (n=4) sampled adolescents and adults and 24% (n=5) sampled adolescents only. Study methods varied, involving one-on-one interviews (57% [n=12]), qualitative focus groups (38% [n=8]), and open-ended questions within a survey (5% [n=1]).

Drivers of Poor Medication Adherence in Asthma

Thematic analyses of the included studies identified several major themes on barriers to asthma medication adherence across the extracted studies. Representative patient sentiments are captured in quotes with key themes provided in Table 2 and discussed further below.

Table 2

Representative Statements from Patients Highlighting Key Drivers Affecting Medication Adherence in Asthma

Theme	Quote
Doubts about the accuracy of asthma diagnosis	“Not every GP has pulmonary function test equipment and (even when he possesses the equipment) can make accurate diagnoses”33“ … maybe even people in general sometimes have trouble breathing … I don’t know what’s normal”32
Daily life is unaffected by asthma	“I don’t use it at all … right after I come from the doctor’s, I take it for 2 to 3 days and then I just forget. It is not that I don’t want to take it, it is that I forget to take it … if I had more symptoms, then I would take it”25“I think it [diabetes] makes me lose sight of my asthma until something, you know, until I can’t breathe or it’s hot out or something”28“Don’t need to take any medication until the pollen season comes. Maybe when it’s really cold”38
Patient-physician communication	“When I go to my appointment, they try to rush, get you in there,rush you out, get you some stuff, take this, do this”29“We never actually sat down and made a plan”29
Suboptimal knowledge of reliever and maintenance medications	“I was like supposed to take so many puffs a day, and I over use it”18
Suboptimal inhaler technique	“Have you taken or inhaled the full dose, or not? You never know”34
Perceived concerns about side effects	“I had to take steroids, which has made me gain weight, which has sort of kept me from exercising”40“ … when I take my medicine, sometimes I still get sick. When I don’t take my medicine, I don’t get sick. I really don’t see where it comes in handy, but I guess if the doctor says I need it, I need it”25
Stigma of inhaler use	“I hate feeling like I’m different. I have a problem when it comes to that and I hold off on my medicine. As you get older, you care what people think more. So I try to hold [asthma medication] off and be cool”29
Perceived medication affordability	“My physician told me to take my medication in the mornings and in the evenings, but I take it every two days because that’s a lot of money”34

Abbreviation: GP, general practitioner.

Doubts About the Accuracy of Asthma Diagnosis

Medication use typically begins with a prescription of medication following diagnosis of the disease; however, an asthma diagnosis did not always translate into regular medication use, with patients having doubts about the accuracy of their diagnosis.

Patients often questioned their diagnosis due to lack of a clear diagnosis from their physician, denial on their part, or distrust of the medical community.18,24,32–35,42

Lingner et al33 engaged adult patients (20–77 years old) in focus group discussions and noted that patients reported a lack of consensus across physicians (primary care vs specialists) on the diagnosis of asthma. Murdoch et al42 conducted face-to-face interviews with patients (17–80 years old) and noted that patients believed there is uncertainty in medical knowledge. Interestingly, for many patients, doubts about the accuracy of their diagnosis may have been based on them not wanting to acknowledge that they had a chronic disease requiring long-term (potentially life-long) treatment.18,35,42

Skepticism about the accuracy of asthma diagnosis was harbored by patients across age groups. McDonald et al24 reported that the absence of a diagnosis, a protracted diagnosis, or a missed diagnosis was a concern for many older patients (≥55 years old), with some patients expressing frustration with repeated attempts to confirm their diagnosis. Interviewed young adults (all aged 22 years) also expressed doubts about the accuracy of their diagnosis, arguing that asthma symptoms may be experienced by all people.32

Daily Life Was Unaffected by Asthma

The perceived lack of impact of asthma on daily life may also contribute to patients’ uncertainty about the accuracy of their diagnosis, such that adults and adolescents develop a “no symptoms, no asthma” outlook about the disease.

Indeed, due to the episodic nature of the disease and related symptoms, many patients did not always consider asymptomatic asthma as an “illness.”25,30,38 Consequently, they discontinued their asthma medication when they felt well; however, when exacerbations occurred or symptoms became pronounced, patients reverted to their asthma medication.24,28,30–35 This took the form of overuse of reliever inhalers,39 as-needed use of maintenance medication,24,26,30,35 or both.31,32 Despite having experienced asthma attacks or exacerbations, many patients felt that their daily life and daily functioning were relatively unaffected by asthma.32 Patients used permissive adherence reasoning by “acting on the spur of symptoms” and justified such behavior because they felt that “asthma was playing out of earshot.” Unstructured medication use was also observed, wherein the maintenance inhaler was not used consistently, with an increase in asthma symptoms triggering the intake of asthma medication.32 Similarly, Peláez et al35 described asthma as “a disease experienced along a continuum,” where symptom-free intervals led to patients neglecting the importance of daily preventive medication.35 McDonald et al24 described intentional non-adherence whereby treatment was self-titrated according to patients’ perceived needs and symptoms. For instance, a patient described using their maintenance inhaler only when symptoms worsened, instead of taking it twice daily as prescribed.24 Among adolescents, it emerged that many based adherence on their belief of how “serious” or “real” their asthma was; as such, some patients did not think they had “real” asthma and, therefore, need not take daily maintenance medication unlike others with more “serious” asthma.30 Similarly, even among adults with uncontrolled asthma, many believed that they were prescribed more ICS than necessary for their level of asthma severity and were thus more likely to underuse ICS and overuse SABAs.31

Unsurprisingly, asthma was also given a lower priority compared with other chronic diseases. Patients deprioritized asthma symptoms, perceiving asthma as less severe compared with other chronic diseases, such as diabetes, heart disease, and arthritis.28,32 Janevic et al28 reported that less than half of patients considered asthma as their “main health problem,” with patients describing how asthma took a “backseat” to conditions they considered more worrisome. This was especially observed during asymptomatic periods of asthma.

Patient-Physician Communication

While medication adherence is considered primarily the domain of the patient, the relationship between the patient and physician exerts a large influence on whether the patient will appropriately use the medication as directed. Poor communication between the patient and physician can further aggravate patients’ confusion about their diagnosis, and this was reported as a significant driver of poor medication adherence.

Our findings revealed that lack of clear communication, discontent with the physician’s diagnosis and choice of medication, and feeling that the patient was being ignored were recurring themes.24,29–31,33,36 Peláez et al36 conducted face-to-face interviews with adults, adolescents, and parents of children who listed certain patient-physician issues, such as lack of a clear diagnosis from the physician, lack of a formal or objective assessment of disease severity, insufficient explanation of asthma and its management, and lack of a patient-centered approach by the physician, as barriers to long-term ICS use. Many patients complained of a lack of an objective assessment of disease severity, due to which the severity of their disease remained unclear to them, leading to confusion in ascertaining the true impact of treatment.36

Speck et al29 conducted focus group discussions with African American adults, many of whom felt frustrated that physicians did not take the time to explain asthma management and simply just prescribed the drugs. Others complained of a lack of an adequate asthma management (action) plan.29 In the study by Lingner et al,33 patients were concerned about a lack of consensus among different physicians regarding the best treatment for them. Patients found disagreements on appropriate medication or the lack of communication between generalists and specialists problematic. Consistent with patients from other studies, they wished to be involved in decisions regarding the most appropriate therapy for them; however, none recalled a shared decision-making process. Patients also wanted their providers to treat them as well-informed individuals and discuss with them all available therapeutic options.33 Poor patient-physician communication directly influenced medication adherence as revealed in open-ended qualitative interviews with urban adults where patients complained that their healthcare providers did not listen to them and, as a result, were more likely to ignore their provider’s recommendations.31

Suboptimal Patient Knowledge

Inadequate communication between the patient and physician can further undermine medication adherence by compromising patients’ understanding of the disease and the importance of medication adherence. Due to suboptimal knowledge, patients may be unable to distinguish between maintenance and reliever medications, have incorrect inhaler technique, and have concerns about the efficacy of medications and potential side effects.

Difference Between Maintenance and Reliever Medications

Many articles noted patients’ struggles with understanding the difference between maintenance and reliever medications, a finding that was observed across age groups.18,26,30,31,34,37,39

Mowrer et al18 observed that despite providers feeling that they had clarified the differences between medication types, many patients with asthma used reliever and maintenance medications interchangeably, while others only used the medication that appeared to work for them. Many adolescents reported confusion regarding their medications and failure to understand the need for maintenance medications, resulting in their improper use.26,39 For instance, a teenage patient reported using a reliever inhaler on the days he forgot to take his maintenance medication, regardless of symptoms experienced.39 Another adolescent reported regular use of a reliever and use of a maintenance inhaler only when symptoms worsened, as the patient believed it was “quick-acting.”26 George et al31 reported that urban adult patients were over-reliant on SABAs and used ICS only when symptomatic, whereas focus groups with rural adolescents revealed a lack of awareness and understanding of asthma symptoms and what asthma control meant, with most patients reporting reliever inhaler use >2 times a week37 (such use would not be consistent with controlled asthma).

Physicians have expressed agreement with these observations. According to Peláez et al,34 many believed that patients did not understand the benefits of daily maintenance medication, and that short-acting reliever medication was more likely to be used because of the immediacy of symptom relief.

Inhaler Technique

Difficulty in using inhalers and inadequate practice and/or demonstration of inhaler use by physicians were frequently reported.18,23,33,34 Many patients had a limited understanding of how to properly use their inhalers.18 In the focus group discussions by Mowrer et al,18 many patients realized that they were receiving only partial doses due to faulty inhaler technique. Davis et al23 highlighted the complexity involved in correctly using inhalers among patients with intellectual disabilities, with several reporting difficulty using inhaler devices in the past. Moreover, while many patients were able to describe what a spacer looked like, they reported using it inconsistently.23 Lingner et al33 reported that patients believed if medication was indeed necessary, drug use should be simplified as much as possible. Notably, some patients discussed the use of a combined, individualized and symptom-driven use of single-agent drugs with their physicians.33

Both patients and physicians noted that some inhalers were not “user-friendly.”34 Patients felt that this was because it was hard to discern whether the inhaler was being used correctly and whether they were receiving the full dose, and physicians acknowledged that using an inhaler required more technical knowledge than taking a pill.34 In addition, patients also felt that physicians did not demonstrate inhaler use33 and wanted physicians to take time to help them practice using an inhaler.

Perceived Lack of Efficacy and Fear of Side Effects

For some patients, the underlying reasons for minimizing consistent use of asthma maintenance medications were perceived lack of efficacy24,25 and perceived dangers associated with medication use (eg, fear of side effects and of addiction or dependence).25,35,42 Face-to-face interviews with older adolescents revealed that, for many, the experience of or concerns about side effects led to poor medication adherence.25 Specific fears or negative beliefs about ICS use were also expressed.31,33,34 These fears were related to drug dependency33 and perceived side effects, such as weight gain,31 muscle pain, dizziness, dry throat,34 and “developing a moon face.”33 Physicians believed that some concerns regarding side effects were, at times, valid, but could also be attributable to irrational or erroneous beliefs.34

Miscellaneous Barriers to Medication Adherence

In addition to the themes described above, several other patient-centered barriers to adherence with inhaled treatment were also noted. Unintentional non-adherence was mainly attributed to general forgetfulness in both adults and adolescents.23,25,26,30,31,36,38,39,41 Many patients either experienced difficulty in incorporating their regular asthma medication into their daily routine23 or found establishing a daily routine challenging.25,30,38,39 Many adolescents and adults also reported feeling embarrassed to use inhalers in public.23,29,30,34 Patients reported using alternatives to ICS, such as relaxation, rest, and drinking water, to manage their asthma symptoms as they were skeptical that asthma could be controlled.31

Healthcare systems can also impose barriers to medication adherence by limiting a patient’s access to appropriate therapy. Indeed, the high cost of some asthma medications was listed by both patients18,29,33,34,38 and physicians34 as negatively affecting medication adherence, with some patients reporting rationing their medications to reduce expenses.18,34

Discussion

This targeted literature review of qualitative studies aimed to improve understanding of the underlying reasons for poor medication adherence in asthma from the patient’s perspective. Several overarching themes related to poor medication adherence emerged across the studies. The drivers of poor medication adherence encompassed patient-centered factors, physician-centered factors, and factors related to the healthcare system, which were interconnected and further drove the cycle of non-adherence.

We found that patients with asthma tended to express doubts about the accuracy of their diagnosis,18,24,32–35 in part because they felt that their daily life was not substantially impacted by asthma.24,25,27–30,32,33,36,38,42 This was compounded by poor patient-physician communication,24,29–31,33,35,36 which contributed to certain erroneous beliefs and suboptimal knowledge about asthma medications. For instance, patients often failed to understand the differences between maintenance and reliever inhalers,18,26,30,34,37,39 had suboptimal inhaler technique,18,23,33,34 and had concerns about the side effects of ICS.25,26,33,34 Other drivers of poor medication adherence included the high cost of asthma medication18,29,33,34,38 and general forgetfulness,23,31,36 especially among young adults and adolescents,25,26,30,38,39,41 and embarrassment about using inhalers in public.23,29,30,34

Several of these aspects were recognized as general drivers that typically affect medication adherence in chronic illnesses; however, we also identified patient-centered drivers that were unique to asthma (Figure 2). Among the general drivers, poor communication between patients and physicians, including a lack of a shared decision-making process; inadequate understanding of the disease; and high medication costs have been previously reported to affect medication adherence in chronic illnesses.43–45 Our study findings highlighted patient-physician communication to be crucial to medication adherence in the management of asthma. Medical visits provide a key opportunity to influence a patient’s intention to take daily ICS;46 however, it was found that many patients described feeling rushed or unheard or that they were “just another number.”24,29

Figure 2

Drivers of medication adherence in asthma derived from qualitative literature.

For chronic conditions, such as cardiovascular disorders, when patients feel better, they are more likely to stop taking their medication.43,44 It is thus a challenge to treat conditions in which the symptoms may be relatively infrequent, as is the case for a variable disease such as asthma. We found that many patients felt that asthma did not affect their daily life, leading to a lack of adherence to daily inhaled therapy.25,29,30,38 Poor adherence to medication is also common in chronic illnesses when a tangible benefit is not immediately evident for a particular treatment.45,47 Not surprisingly, our findings revealed that patients questioned the need for daily maintenance medication as they did not understand the benefits of daily maintenance therapy for an episodic condition such as asthma.25,27,31 Similar to the findings of the INSPIRE study,9 we found that many patients took maintenance medication as needed or altered their medication dose according to their perceived disease burden.18,26,31,33 Due to the long-term use of medication in chronic illnesses, a fear of side effects can also compromise medication adherence.43,44 We observed that both adolescent and adult patients reported medication concerns, specifically a fear of side effects from ICS use.23,25,31,33,40 Consistent with our findings, multiple studies have reported patients’ concerns regarding the prescription of ICS,17,48,49 which have translated into ICS underuse, including symptom-directed usage and improved adherence only in the time up to and after an exacerbation.8,17

Suboptimal health literacy among patients contributes to a lack of understanding of the disease and is a common reason for poor medication adherence.43,45 This is especially problematic in asthma due to the often complex treatment regimens and is the basis of several asthma-specific barriers to medication adherence. Patients lacked an understanding of the difference between reliever and maintenance medications.18,24,26 They did not recognize the need for daily ICS therapy and reported overusing SABAs because they offered rapid relief.31,32,39 Furthermore, variations in the terminologies used for reliever and maintenance medications can be a source of confusion. Multiple terms are used for SABA therapy, such as “rescue” and “reliever,” and for ICS therapy, such as “maintenance,” “preventive,” and “controller,” underscoring the need to standardize terminology. In addition, incorrect or suboptimal inhaler technique led to non-adherence, as patients found it challenging to use the inhaler correctly and to identify whether they had received the full dose of medication.23,33,34 Interestingly, while patients had suboptimal knowledge about their medication,18,24,26 they were still interested in a shared decision-making process and indicated that they did not want to simply “trust” their physician.33 This gap in communication between patients and physicians highlights the need for improvement in the patient-physician relationship and the importance of empowering patients through better communication with their physicians so that they are motivated to adhere to their medication. Indeed, a shared decision-making process between physicians and patients, accommodating patient goals and preferences, led to increased medication adherence and improved clinical outcomes compared with an approach where physicians made decisions independently.50 In addition, self-management involving personalized written action plans with regular physician review can be a tool to improve physician-patient communication and patient empowerment,51 and has been associated with improved clinical outcomes such as fewer emergency department visits and hospital admissions and better lung function.52

Taken together, our findings on patient drivers of poor medication adherence are consistent with the current understanding of this issue and highlight the challenges associated with improving adherence. However, most drivers for poor medication adherence were deliberate in nature and may therefore be modifiable through strategies involving patients, physicians, and the healthcare system. Patient-centered interventions with proven effectiveness include patient engagement and education initiatives, such as routine counseling and training for patients to better understand their condition,53 training on inhaler technique,54 and the introduction of programs rewarding patients for optimal adherence and outcomes.55 In addition, the use of digital tools, such as electronic reminders or trackers, and “smart” inhaler technology to support asthma management can facilitate better adherence.56–58 Physician-centered interventions including initiatives aimed at encouraging nurses, pharmacists, and physicians to provide integrative and supportive follow-up care may also be necessary to address the gap in communication between patients and physicians. Physician education might also focus on inhaler technique training, as physicians themselves may be frequently unable to use inhalers correctly59–61 and, thus, are unlikely to be able to demonstrate their appropriate use to patients. Other strategies include the use of objective diagnostic tests3 such as spirometry or peak expiratory flow measurements to confirm diagnosis in order to avoid ambiguity and improve communication between physicians to avoid conflicting diagnoses.

Healthcare-centered interventions, such as simplification of the asthma regimen by involving the use of single-inhaler therapy instead of multiple inhalers, may also help improve medication adherence in asthma.62–65 Furthermore, one of the recurring themes in our study—consistent with reported paradoxes in the treatment of asthma66,67—was the use of medication only when symptoms occur (ie, short-acting reliever alone) and avoidance of treatment perceived to be unnecessary (ie, ICS maintenance). Unlike ICS, SABAs lack any inherent anti–inflammatory properties68 and thus do not treat the underlying inflammation of asthma. In addition, SABA overuse (≥3 canisters/year) is associated with an increased risk of severe exacerbations.2,69 GINA recommendations also acknowledge that adherence to ICS is poor in patients with mild asthma, exposing them to the risks of SABA-only treatment.2 Thus, updated GINA 2019 recommendations no longer recommend starting with SABA-only treatment, and instead indicate as-needed, low-dose ICS-formoterol as the joint preferred reliever/controller at GINA Steps 1−2.2

To our knowledge, this is the first targeted literature review to provide a comprehensive qualitative report of the drivers of poor medication adherence in asthma from the patient’s perspective, which employed a quality assessment analysis, included evidence collected from various qualitative methodologies, covered 7 geographical regions, and comprised patients across age groups. However, certain limitations should be acknowledged. Clear and equivocal contextualization of the results of qualitative research can be problematic for several reasons. For instance, precise methods of the qualitative analysis were not always clearly specified in the studies included; differences in sampling strategies could have affected the representativeness of the obtained samples and the differential use of data from one-on-one interviews vs focus groups could have affected the breadth and depth of the obtained data. Finally, while extensive literature searches were conducted using PubMed and EMBASE, health-related qualitative research databases such as CINAHL and PsycINFO were not used, which could have led to article omissions.

Conclusions

Medication adherence is a challenge in a chronic illness such as asthma. We identified key factors, such as patients’ low perceived need for asthma medications, inadequate communication between patients and physicians, perceived medication concerns, and suboptimal patient knowledge including incorrect inhaler technique, driving poor adherence to asthma medication, which manifests as underuse of ICS and over-reliance on SABAs. To recognize the full benefits of current therapies, optimal asthma care needs to target these patient- and physician-centered barriers through effective multifactorial interventions.