Alar Kaskikallio1, Mira Karrasch2, Juha Koikkalainen3, Jyrki Lötjönen3, Juha O Rinne4,5, Terhi Tuokkola4, Riitta Parkkola6, Petra Grönholm-Nyman2. 1. Åbo Akademi University, Turku, Finland, alar.kaskikallio@abo.fi. 2. Åbo Akademi University, Turku, Finland. 3. Combinostics Ltd., Tampere, Finland. 4. Turku PET Centre, University of Turku, Turku, Finland. 5. Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland. 6. Department of Radiology, University and University Hospital of Turku, Turku, Finland.
Abstract
BACKGROUND: Brain changes involving the white matter (WM), often an indication of cerebrovascular pathology, are frequently seen in patients with mild cognitive impairment (MCI) and Alzheimer disease (AD). Few studies have examined possible cognitive domain- or group-specific cognitive effects of WM pathology in old age, MCI, and AD. OBJECTIVE: Our purpose was to examine the relationship between WM hyperintensities (WMH), a typical marker for WM pathology, and cognitive functioning in healthy old age and pathological aging using quantified MRI data. METHODS: We utilized multidomain neuropsychological data and quantified MRI data from a sample of 42 cognitively healthy older adults and 44 patients with MCI/AD (total n = 86). RESULTS: After controlling for age and education, WMH in the temporal and parieto-occipital lobes was associated with impairments in processing speed and parieto-occipital pathology with verbal memory impairment in the whole sample. Additionally, temporal WMH was associated with impaired processing speed in the patient group specifically. CONCLUSIONS: WM pathology is strongly associated with impaired processing speed, and our results indicate that these impairments arise from WMH in the temporal and parieto-occipital regions. In MCI and AD patients with temporal WMH, processing speed impairments are especially prominent. The results of this study increase our knowledge of cognitive repercussions stemming from temporal and/or parieto-occipital WM pathology in healthy and pathological aging.
BACKGROUND: Brain changes involving the white matter (WM), often an indication of cerebrovascular pathology, are frequently seen in patients with mild cognitive impairment (MCI) and Alzheimer disease (AD). Few studies have examined possible cognitive domain- or group-specific cognitive effects of WM pathology in old age, MCI, and AD. OBJECTIVE: Our purpose was to examine the relationship between WM hyperintensities (WMH), a typical marker for WM pathology, and cognitive functioning in healthy old age and pathological aging using quantified MRI data. METHODS: We utilized multidomain neuropsychological data and quantified MRI data from a sample of 42 cognitively healthy older adults and 44 patients with MCI/AD (total n = 86). RESULTS: After controlling for age and education, WMH in the temporal and parieto-occipital lobes was associated with impairments in processing speed and parieto-occipital pathology with verbal memory impairment in the whole sample. Additionally, temporal WMH was associated with impaired processing speed in the patient group specifically. CONCLUSIONS:WM pathology is strongly associated with impaired processing speed, and our results indicate that these impairments arise from WMH in the temporal and parieto-occipital regions. In MCI and ADpatients with temporal WMH, processing speed impairments are especially prominent. The results of this study increase our knowledge of cognitive repercussions stemming from temporal and/or parieto-occipital WM pathology in healthy and pathological aging.
Authors: Alar Kaskikallio; Mira Karrasch; Juha Koikkalainen; Jyrki Lötjönen; Juha O Rinne; Terhi Tuokkola; Riitta Parkkola; Petra Grönholm-Nyman Journal: Front Aging Neurosci Date: 2021-05-06 Impact factor: 5.750
Authors: Maggie Roy; Mélanie Fortier; François Rheault; Manon Edde; Etienne Croteau; Christian-Alexandre Castellano; Francis Langlois; Valérie St-Pierre; Bernard Cuenoud; Christian Bocti; Tamas Fulop; Maxime Descoteaux; Stephen C Cunnane Journal: Alzheimers Dement (N Y) Date: 2021-11-17
Authors: Antoine Garnier-Crussard; Salma Bougacha; Miranka Wirth; Sophie Dautricourt; Siya Sherif; Brigitte Landeau; Julie Gonneaud; Robin De Flores; Vincent de la Sayette; Denis Vivien; Pierre Krolak-Salmon; Gaël Chételat Journal: Alzheimers Dement Date: 2021-07-28 Impact factor: 16.655