Lorenzo Maria Donini1, Aldo Rosano2, Luca Di Lazzaro3, Carla Lubrano3, Mariagrazia Carbonelli4, Alessandro Pinto3, Anna Maria Giusti3, Andrea Lenzi3, Mario Siervo5. 1. Medical Pathophysiology, Food Science and Endocrinology Section, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy, lorenzomaria.donini@uniroma1.it. 2. Italian National Agency for Regional Healthcare Services (AGENAS), Rome, Italy. 3. Medical Pathophysiology, Food Science and Endocrinology Section, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy. 4. San Camillo-Forlanini Hospital, Rome, Italy. 5. Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, United Kingdom.
Abstract
Obesity is a rapidly growing public health problem affecting an increasing number of countries worldwide and creating substantial financial and health burdens. Obesity has a negative impact on health-related quality of life (HRQoL) with reference to physical and mental health status, social relationships, and economic factors. The aim of the present study is to investigate the association of number of comorbidities, psychological status, and disability level with HRQoL in a sample of subjects with obesity. METHODS: A total of 273 subjects with obesity (199 women and 74 men) were recruited. Medical history and anthropometric measurements were carried out. The Italian version of the Laval questionnaire, the TSD-OC (SIO test for obesity-related disabilities), and SCL-90 (Symptom Checklist-90) tests were administered. The association between HRQoL (global and different domains scores of the Laval questionnaire - dependent variable) and age, body mass index (BMI), comorbidity, TSD-OC, and SCL-90 was analysed using a stepwise linear regression model. RESULTS: BMI, disability (TSD-OC global score), and psychological symptoms (SCL-90 global severity index) were found to be the main determinants of HRQoL. Single domains of HRQoL (symptoms, activity/mobility, personal hygiene/clothing, emotions, social interaction, and sexual life) showed different patterns of associations with each domain of the Laval questionnaire. BMI, pain, and social life disruptions were found to be significantly associated with most of the HRQoL domains while age, comorbidities, psychological problems (depression, interpersonal symptoms, somatization), and disability were associated with only some domains of the Laval questionnaire. Education, psychological symptoms (obsessive-compulsive, anxiety, hostility, phobic anxiety, paranoid ideation), and disability domains (stiffness, housework, outdoor activities, occupational activities) were not associated with any of the dimensions of the Laval questionnaire. DISCUSSION/ CONCLUSION: The present study identified key determinants of QoL in subjects with obesity, which could help in refining the multidimensional diagnostic assessment of obesity as well as designing more effective interventions to improve HRQoL in these patients.
Obesity is a rapidly growing public health problem affecting an increasing number of countries worldwide and creating substantial financial and health burdens. Obesity has a negative impact on health-related quality of life (HRQoL) with reference to physical and mental health status, social relationships, and economic factors. The aim of the present study is to investigate the association of number of comorbidities, psychological status, and disability level with HRQoL in a sample of subjects with obesity. METHODS: A total of 273 subjects with obesity (199 women and 74 men) were recruited. Medical history and anthropometric measurements were carried out. The Italian version of the Laval questionnaire, the TSD-OC (SIO test for obesity-related disabilities), and SCL-90 (Symptom Checklist-90) tests were administered. The association between HRQoL (global and different domains scores of the Laval questionnaire - dependent variable) and age, body mass index (BMI), comorbidity, TSD-OC, and SCL-90 was analysed using a stepwise linear regression model. RESULTS: BMI, disability (TSD-OC global score), and psychological symptoms (SCL-90 global severity index) were found to be the main determinants of HRQoL. Single domains of HRQoL (symptoms, activity/mobility, personal hygiene/clothing, emotions, social interaction, and sexual life) showed different patterns of associations with each domain of the Laval questionnaire. BMI, pain, and social life disruptions were found to be significantly associated with most of the HRQoL domains while age, comorbidities, psychological problems (depression, interpersonal symptoms, somatization), and disability were associated with only some domains of the Laval questionnaire. Education, psychological symptoms (obsessive-compulsive, anxiety, hostility, phobic anxiety, paranoid ideation), and disability domains (stiffness, housework, outdoor activities, occupational activities) were not associated with any of the dimensions of the Laval questionnaire. DISCUSSION/ CONCLUSION: The present study identified key determinants of QoL in subjects with obesity, which could help in refining the multidimensional diagnostic assessment of obesity as well as designing more effective interventions to improve HRQoL in these patients.
Authors: Eleonora Poggiogalle; Luca Di Lazzaro; Alessandro Pinto; Silvia Migliaccio; Andrea Lenzi; Lorenzo M Donini Journal: Int J Endocrinol Date: 2014-02-23 Impact factor: 3.257
Authors: Lorenzo Maria Donini; Aldo Rosano; Luca Di Lazzaro; Eleonora Poggiogalle; Carla Lubrano; Silvia Migliaccio; Mariagrazia Carbonelli; Alessandro Pinto; Andrea Lenzi Journal: Health Qual Life Outcomes Date: 2017-05-15 Impact factor: 3.186
Authors: Lorenzo M Donini; Luca Busetto; Stephan C Bischoff; Tommy Cederholm; Maria D Ballesteros-Pomar; John A Batsis; Juergen M Bauer; Yves Boirie; Alfonso J Cruz-Jentoft; Dror Dicker; Stefano Frara; Gema Frühbeck; Laurence Genton; Yftach Gepner; Andrea Giustina; Maria Cristina Gonzalez; Ho-Seong Han; Steven B Heymsfield; Takashi Higashiguchi; Alessandro Laviano; Andrea Lenzi; Ibolya Nyulasi; Edda Parrinello; Eleonora Poggiogalle; Carla M Prado; Javier Salvador; Yves Rolland; Ferruccio Santini; Mireille J Serlie; Hanping Shi; Cornel C Sieber; Mario Siervo; Roberto Vettor; Dennis T Villareal; Dorothee Volkert; Jianchun Yu; Mauro Zamboni; Rocco Barazzoni Journal: Obes Facts Date: 2022-02-23 Impact factor: 4.807
Authors: Nicole M Gilbertson; Natalie Z M Eichner; Julian M Gaitán; Mahnoor Khurshid; Elizabeth A Rexrode; Sibylle Kranz; Peter T Hallowell; Steven K Malin Journal: Physiol Rep Date: 2021-11