Literature DB >> 32207496

A photo-triggerable aptamer nanoswitch for spatiotemporal controllable siRNA delivery.

Deyao Zhao1, Ge Yang2, Qing Liu3, Wenjing Liu3, Yuhua Weng2, Yi Zhao2, Feng Qu2, Lele Li4, Yuanyu Huang2.   

Abstract

A photo-triggerable aptamer nanoswitch was proposed for spatiotemporal regulation of siRNA delivery. Recognition between AS1411 and nucleolin was effectively blocked by a photo-labile complementary oligonucleotide, which could be reactivated with photo-irradiation, resulting in efficient tumor-targeted siRNA internalization and gene silencing in vitro and in vivo.

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Year:  2020        PMID： 32207496     DOI： 10.1039/d0nr00301h

Source DB:  PubMed          Journal:  Nanoscale        ISSN： 2040-3364            Impact factor:   7.790


  4 in total

1.  siRNA Design and GalNAc-Empowered Hepatic Targeted Delivery.

Authors:  Mei Lu; Mengjie Zhang; Bo Hu; Yuanyu Huang
Journal:  Methods Mol Biol       Date:  2021

2.  Ionizable liposomal siRNA therapeutics enables potent and persistent treatment of Hepatitis B.

Authors:  Yuanyu Huang; Shuquan Zheng; Zhaoxu Guo; Xavier de Mollerat du Jeu; Xing-Jie Liang; Zhiwei Yang; Hong-Yan Zhang; Shan Gao; Zicai Liang
Journal:  Signal Transduct Target Ther       Date:  2022-02-11

Review 3.  The potential of RNA-based therapy for kidney diseases.

Authors:  Tjessa Bondue; Lambertus van den Heuvel; Elena Levtchenko; Roland Brock
Journal:  Pediatr Nephrol       Date:  2022-05-04       Impact factor: 3.651

4.  Current trends in delivery of non-viral nucleic acid-based therapeutics for improved efficacy.

Authors:  Meltem Avci-Adali; Hélder A Santos
Journal:  Adv Drug Deliv Rev       Date:  2022-04-12       Impact factor: 17.873
  4 in total

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