Ming Liu1,2, Ya Gao1,2, Yuan Yuan3, Shuzhen Shi1,2, Kelu Yang4, Jiarui Wu5, Junhua Zhang6, Jinhui Tian1,2. 1. Evidence Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, PR China. 2. Key Laboratory of Evidence-Based Medicine & Knowledge Translation of Gansu Province, Lanzhou 730000, PR China. 3. Gansu University of Chinese Medicine, Lanzhou 730000, PR China. 4. School of Nursing, Lanzhou University, Lanzhou 730000, PR China. 5. Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100000, PR China. 6. Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China.
Abstract
Aim: Our study aimed to analyze the characteristics of papers published on CAR T-cell in the field of cancer and explore the existing hot topics and prospects. Materials & methods: We explored the global hotspots and future prospects regarding CAR T-cell therapy in cancer research. Papers of CAR T-cell research were retrieved from the Web of Science database. Analysis was performed using VOSviewer, CiteSpace and Excel software. Results: A total number of 1994 papers related to CAR T-cell research of cancer were included. Molecular Therapy published the most papers (n = 85, 4.26%). A total of 9792 authors participated in the publication of all papers. 62 countries and 2065 institutions have participated in the publication of all papers. Conclusion: Research trends are to improve the immunosuppressive microenvironment of cancer, optimize the structure of CAR T-cells and develop 'super CAR T-cell' by using gene-editing technology.
Aim: Our study aimed to analyze the characteristics of papers published on CAR T-cell in the field of cancer and explore the existing hot topics and prospects. Materials & methods: We explored the global hotspots and future prospects regarding CAR T-cell therapy in cancer research. Papers of CAR T-cell research were retrieved from the Web of Science database. Analysis was performed using VOSviewer, CiteSpace and Excel software. Results: A total number of 1994 papers related to CAR T-cell research of cancer were included. Molecular Therapy published the most papers (n = 85, 4.26%). A total of 9792 authors participated in the publication of all papers. 62 countries and 2065 institutions have participated in the publication of all papers. Conclusion: Research trends are to improve the immunosuppressive microenvironment of cancer, optimize the structure of CAR T-cells and develop 'super CAR T-cell' by using gene-editing technology.
Entities:
Keywords:
CAR T-cell; CiteSpace; VOSviewer; bibliometric analysis