Kimberly C Paul1, Fróði Debes2, Eina Eliasen2, Pál Weihe2,3, Maria Skaalum Petersen4,5. 1. Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA. 2. Department of Occupational Medicine and Public Health, The Faroese Hospital System, Tórshavn, Faroe Islands. 3. Faculty of Health Sciences, Centre of Health Science, University of the Faroe Islands, Tórshavn, Faroe Islands. 4. Department of Occupational Medicine and Public Health, The Faroese Hospital System, Tórshavn, Faroe Islands. maria@health.fo. 5. Faculty of Health Sciences, Centre of Health Science, University of the Faroe Islands, Tórshavn, Faroe Islands. maria@health.fo.
Abstract
BACKGROUND: Using the Faroese Septuagenarian cohort, we aimed to describe the incidence of dementia and assess the validity of neurocognitive tests to predict subsequent dementia diagnosis. METHODS: In this population-based cohort, 713 Faroese septuagenarians aged 70-74 years without dementia, underwent clinical and neuropsychological examinations. After 10-years of follow-up, information was collected on all participants referred for cognitive evaluations and diagnosed with dementia. Incidence rates were calculated and presented with 95% confidence intervals (CIs), assuming a Poisson distribution. We then performed discriminant analysis to determine the best set of neuropsychological tests to identify those who would develop dementia. RESULTS: Over the 10-years, 65 participants (9.1%) were diagnosed with dementia, with a 10-year incidence rate of 1063 cases per 100,000 person years (95% CI 825, 1343). Women had a greater incidence than men (incidence rate ratio (IRR) = 1.58; 95% CI 0.93, 2.71). After stepwise selection, gender and six neuropsychological measures were selected to discriminate between those who would and would not develop dementia. Overall, the model was able to correctly identify 82% of those who would not develop dementia (specificity) and 71% of those who would (sensitivity). CONCLUSIONS: These results indicate that among a greater number of tests covering a broad range of cognitive abilities, tests reflecting verbal and visual learning and recall, visuospatial function, attention, and encoding into and retrieval from long-term memory may be helpful in identifying patients in the pre-symptomatic phase of dementia. Thus, helping care-givers identify patients at a higher risk of developing dementia and adjusting management of care accordingly.
BACKGROUND: Using the Faroese Septuagenarian cohort, we aimed to describe the incidence of dementia and assess the validity of neurocognitive tests to predict subsequent dementia diagnosis. METHODS: In this population-based cohort, 713 Faroese septuagenarians aged 70-74 years without dementia, underwent clinical and neuropsychological examinations. After 10-years of follow-up, information was collected on all participants referred for cognitive evaluations and diagnosed with dementia. Incidence rates were calculated and presented with 95% confidence intervals (CIs), assuming a Poisson distribution. We then performed discriminant analysis to determine the best set of neuropsychological tests to identify those who would develop dementia. RESULTS: Over the 10-years, 65 participants (9.1%) were diagnosed with dementia, with a 10-year incidence rate of 1063 cases per 100,000 person years (95% CI 825, 1343). Women had a greater incidence than men (incidence rate ratio (IRR) = 1.58; 95% CI 0.93, 2.71). After stepwise selection, gender and six neuropsychological measures were selected to discriminate between those who would and would not develop dementia. Overall, the model was able to correctly identify 82% of those who would not develop dementia (specificity) and 71% of those who would (sensitivity). CONCLUSIONS: These results indicate that among a greater number of tests covering a broad range of cognitive abilities, tests reflecting verbal and visual learning and recall, visuospatial function, attention, and encoding into and retrieval from long-term memory may be helpful in identifying patients in the pre-symptomatic phase of dementia. Thus, helping care-givers identify patients at a higher risk of developing dementia and adjusting management of care accordingly.
Authors: Anna L Choi; Pal Weihe; Esben Budtz-Jørgensen; Poul J Jørgensen; Jukka T Salonen; Tomi-Pekka Tuomainen; Katsuyuki Murata; Hans Petur Nielsen; Maria Skaalum Petersen; Jórun Askham; Philippe Grandjean Journal: Environ Health Perspect Date: 2008-10-16 Impact factor: 9.031
Authors: Jiandong Zhou; Sharen Lee; Wing Tak Wong; Khalid Bin Waleed; Keith Sai Kit Leung; Teddy Tai Loy Lee; Abraham Ka Chung Wai; Tong Liu; Carlin Chang; Bernard Man Yung Cheung; Qingpeng Zhang; Gary Tse Journal: J Am Med Inform Assoc Date: 2022-01-12 Impact factor: 7.942