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Literature DB >> 32206916

Bioactive borate glass triggers phenotypic changes in adipose stem cells.

Nathan J Thyparambil¹, Lisa C Gutgesell¹, Bradley A Bromet¹, Lauren E Flowers¹, Samantha Greaney¹, Delbert E Day^2,3, Julie A Semon^4,5.

Abstract

A bioactive borate glass, 13-93B3 (B3), has been used successfully in the clinic to treat chronic, nonhealing wounds without scarring. However, the mechanism by which B3 stimulates wound healing is poorly understood. Because adipose stem cells (ASCs) have been shown to have multiple roles in wound repair, we hypothesized that B3 triggers ASCs. In this study, we evaluate the effects of B3 on ASC survival, migration, differentiation, and protein secretion in vitro. In concentrations ≤10 mg/ml, B3 did not affect ASC viability under static conditions. B3 promoted the migration of ASCs but did not increase differentiation into bone or fat. B3 also decreased ASCs secretion of collagen I, PAI-1, MCP-1, DR6, DKK-1, angiogenin, IL-1, IGFBP-6, VEGF, and TIMP-2; increased expression of IL-1R and E-selectin; had a transient decrease in IL-6 secretion; and had a transient increase in bFGF secretion. Together, these results show that B3 alters the protein secretion of ASCs.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2020 PMID： 32206916 DOI： 10.1007/s10856-020-06366-w

Source DB: PubMed Journal: J Mater Sci Mater Med ISSN： 0957-4530 Impact factor: 3.896

87 in total

1. Tumor necrosis factor-alpha induces the expression of DR6, a member of the TNF receptor family, through activation of NF-kappaB.

Authors: G M Kasof; J J Lu; D Liu; B Speer; K N Mongan; B C Gomes; M V Lorenzi
Journal: Oncogene Date: 2001-11-29 Impact factor: 9.867

2. In vitro stimulation of vascular endothelial growth factor by borate-based glass fibers under dynamic flow conditions.

Authors: Sisi Chen; Qingbo Yang; Richard K Brow; Kun Liu; Katherine A Brow; Yinfa Ma; Honglan Shi
Journal: Mater Sci Eng C Mater Biol Appl Date: 2016-12-23 Impact factor: 7.328

3. Angiogenic effects of borate glass microfibers in a rodent model.

Authors: Yinan Lin; Roger F Brown; Steven B Jung; Delbert E Day
Journal: J Biomed Mater Res A Date: 2014-02-26 Impact factor: 4.396

4. Recent insights into the actions of IGFBP-6.

Authors: Leon A Bach
Journal: J Cell Commun Signal Date: 2015-03-26 Impact factor: 5.782

5. Cytotoxicity assessment of modified bioactive glasses with MLO-A5 osteogenic cells in vitro.

Authors: Vernon C Modglin; Roger F Brown; Steven B Jung; Delbert E Day
Journal: J Mater Sci Mater Med Date: 2013-02-08 Impact factor: 3.896

6. Culture effects of epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) on cryopreserved human adipose-derived stromal/stem cell proliferation and adipogenesis.

Authors: Teddi L Hebert; Xiying Wu; Gang Yu; Brian C Goh; Yuan-Di C Halvorsen; Zhong Wang; Cedric Moro; Jeffrey M Gimble
Journal: J Tissue Eng Regen Med Date: 2009-10 Impact factor: 3.963

7. MicroRNA profiling reveals age-dependent differential expression of nuclear factor κB and mitogen-activated protein kinase in adipose and bone marrow-derived human mesenchymal stem cells.

Authors: Amitabh C Pandey; Julie A Semon; Deepak Kaushal; Regina P O'Sullivan; Julie Glowacki; Jeffery M Gimble; Bruce A Bunnell
Journal: Stem Cell Res Ther Date: 2011-11-14 Impact factor: 6.832

8. Bioactive copper-doped glass scaffolds can stimulate endothelial cells in co-culture in combination with mesenchymal stem cells.

Authors: Subha N Rath; Andreas Brandl; Daniel Hiller; Alexander Hoppe; Uwe Gbureck; Raymund E Horch; Aldo R Boccaccini; Ulrich Kneser
Journal: PLoS One Date: 2014-12-03 Impact factor: 3.240

Bioactive borate glass triggers phenotypic changes in adipose stem cells.

1. Tumor necrosis factor-alpha induces the expression of DR6, a member of the TNF receptor family, through activation of NF-kappaB.

2. In vitro stimulation of vascular endothelial growth factor by borate-based glass fibers under dynamic flow conditions.

3. Angiogenic effects of borate glass microfibers in a rodent model.

4. Recent insights into the actions of IGFBP-6.

5. Cytotoxicity assessment of modified bioactive glasses with MLO-A5 osteogenic cells in vitro.

6. Culture effects of epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) on cryopreserved human adipose-derived stromal/stem cell proliferation and adipogenesis.

7. MicroRNA profiling reveals age-dependent differential expression of nuclear factor κB and mitogen-activated protein kinase in adipose and bone marrow-derived human mesenchymal stem cells.

8. Bioactive copper-doped glass scaffolds can stimulate endothelial cells in co-culture in combination with mesenchymal stem cells.

Review 9. Mesenchymal stem cells migration homing and tracking.

Review 10. Augmentation of Dermal Wound Healing by Adipose Tissue-Derived Stromal Cells (ASC).

1. Bioprinting with human stem cell-laden alginate-gelatin bioink and bioactive glass for tissue engineering.

2. CaO-B₂O₃-SiO₂ glass fibers for wound healing.