Comparative study of deep learning models for optical coherence tomography angiography.

Optical coherence tomography angiography (OCTA) is a promising imaging modality for microvasculature studies. Meanwhile, deep learning has achieved rapid development in image-to-image translation tasks. Some studies have proposed applying deep learning models to OCTA reconstruction and have obtained preliminary results. However, current studies are mostly limited to a few specific deep neural networks. In this paper, we conducted a comparative study to investigate OCTA reconstruction using deep learning models. Four representative network architectures including single-path models, U-shaped models, generative adversarial network (GAN)-based models and multi-path models were investigated on a dataset of OCTA images acquired from rat brains. Three potential solutions were also investigated to study the feasibility of improving performance. The results showed that U-shaped models and multi-path models are two suitable architectures for OCTA reconstruction. Furthermore, merging phase information should be the potential improving direction in further research.