Ying Zhu1, Ying Cui2, Jay C Wang3, Yifan Lu3, Rebecca Zeng4, Raviv Katz3, David M Wu5, Dean Eliott6, Demetrios G Vavvas6, Deeba Husain6, Joan W Miller6, Leo A Kim6, John B Miller7. 1. Retina, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA; Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, Massachusetts, USA. 2. Retina, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA; Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, Massachusetts, USA; Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. 3. Retina, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA; Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, Massachusetts, USA. 4. Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, Massachusetts, USA; Boston University School of Medicine, Boston, Massachusetts, USA. 5. Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, USA. 6. Retina, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA. 7. Retina, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA; Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, Massachusetts, USA. Electronic address: john_miller@meei.harvard.edu.
Abstract
PURPOSE: To compare different scan protocols of wide-field swept-source optical coherence tomography angiography (SS-OCTA) for the detection of diabetic retinopathy (DR) lesions. DESIGN: Comparison of diagnostic approaches. METHODS: A prospective, observational study was conducted at Massachusetts Eye and Ear from December 2018 to July 2019. Proliferative diabetic retinopathy (PDR), nonproliferative diabetic retinopathy (NPDR), and diabetic patients without DR were included. All patients were imaged using SS-OCTA using the following scan protocol: 3- × 3-mm Angio centered on the fovea; 6- × 6-mm Angio centered on the fovea and the optic disc; 15- × 9-mm Montage; and 12- × 12-mm Angio centered on the fovea and the optic disc. Images were independently evaluated by 2 graders for the presence or absence of DR lesions including microaneurysms, intraretinal microvascular abnormalities, neovascularization, nonperfusion areas, venous looping, and hard exudates. All statistical analyses were performed using commercial software. RESULTS: A total of 176 eyes in 119 participants were included in the study. The detection rate of neovascularization on 6- × 6-mm Angio centered on the fovea was approximately one-half that on 15- × 9-mm Montage (P < .05) imaging. Combining 6- × 6-mm Angio imaging centered on the fovea and the optic disc could increase the rate to approximately two-thirds (P < .05). The 12- × 12-mm Angio imaging centered on the combination of fovea and optic disc had detection rates comparable to those of 15- × 9-mm Montage imaging for all DR lesions (P > .05). For microaneurysms, 6- × 6-mm Angio had better performance than 15- × 9-mm Montage (P < .05). CONCLUSIONS: Wide-field SS-OCTA images were useful in detecting DR lesions. The 12- × 12-mm Angio imaging centered on the fovea and on the optic disc may be an optimal balance between speed and efficacy for evaluation of DR in clinical practice.
PURPOSE: To compare different scan protocols of wide-field swept-source optical coherence tomography angiography (SS-OCTA) for the detection of diabetic retinopathy (DR) lesions. DESIGN: Comparison of diagnostic approaches. METHODS: A prospective, observational study was conducted at Massachusetts Eye and Ear from December 2018 to July 2019. Proliferative diabetic retinopathy (PDR), nonproliferative diabetic retinopathy (NPDR), and diabeticpatients without DR were included. All patients were imaged using SS-OCTA using the following scan protocol: 3- × 3-mm Angio centered on the fovea; 6- × 6-mm Angio centered on the fovea and the optic disc; 15- × 9-mm Montage; and 12- × 12-mm Angio centered on the fovea and the optic disc. Images were independently evaluated by 2 graders for the presence or absence of DR lesions including microaneurysms, intraretinal microvascular abnormalities, neovascularization, nonperfusion areas, venous looping, and hard exudates. All statistical analyses were performed using commercial software. RESULTS: A total of 176 eyes in 119 participants were included in the study. The detection rate of neovascularization on 6- × 6-mm Angio centered on the fovea was approximately one-half that on 15- × 9-mm Montage (P < .05) imaging. Combining 6- × 6-mm Angio imaging centered on the fovea and the optic disc could increase the rate to approximately two-thirds (P < .05). The 12- × 12-mm Angio imaging centered on the combination of fovea and optic disc had detection rates comparable to those of 15- × 9-mm Montage imaging for all DR lesions (P > .05). For microaneurysms, 6- × 6-mm Angio had better performance than 15- × 9-mm Montage (P < .05). CONCLUSIONS: Wide-field SS-OCTA images were useful in detecting DR lesions. The 12- × 12-mm Angio imaging centered on the fovea and on the optic disc may be an optimal balance between speed and efficacy for evaluation of DR in clinical practice.
Authors: Ying Cui; Ying Zhu; Edward S Lu; Rongrong Le; Inês Laíns; Raviv Katz; Jay C Wang; Itika Garg; Yifan Lu; Rebecca Zeng; Dean Eliott; Demetrios G Vavvas; Deeba Husain; Joan W Miller; Leo A Kim; David M Wu; John B Miller Journal: Ophthalmology Date: 2021-02-26 Impact factor: 14.277
Authors: Ying Cui; Ying Zhu; Jay C Wang; Yifan Lu; Rebecca Zeng; Raviv Katz; Filippos Vingopoulos; Rongrong Le; Inês Laíns; David M Wu; Dean Eliott; Demetrios G Vavvas; Deeba Husain; Joan W Miller; Leo A Kim; John B Miller Journal: Br J Ophthalmol Date: 2020-06-26 Impact factor: 5.908
Authors: Mohamed Ashraf; Jerry D Cavallerano; Jennifer K Sun; Paolo S Silva; Lloyd Paul Aiello Journal: J Clin Med Date: 2021-07-27 Impact factor: 4.964