Fanny Petermann-Rocha1, Shuai Yang2, Stuart R Gray2, Jill P Pell2, Carlos Celis-Morales3, Frederick K Ho4. 1. Institute of Health and Wellbeing, University of Glasgow, Glasgow, G12 8RZ, UK; British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA, UK. 2. British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA, UK. 3. Institute of Health and Wellbeing, University of Glasgow, Glasgow, G12 8RZ, UK; British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA, UK; Centre for Exercise Physiology Research (CIFE), Universidad Mayor, Santiago, Chile. 4. Institute of Health and Wellbeing, University of Glasgow, Glasgow, G12 8RZ, UK. Electronic address: Frederick.Ho@glasgow.ac.uk.
Abstract
BACKGROUND: Sarcopenic obesity is defined as a combination of sarcopenia and obesity. Previous studies have shown a positive association between sarcopenia and respiratory disease, while other studies have identified that obese individuals have a lower risk for respiratory diseases. This study aimed to investigate the association of obesity, sarcopenia and sarcopenic obesity with respiratory disease incidence and mortality. METHODS: Data from 170,083 participants from the prospective UK Biobank study were included. Sarcopenic obesity was defined as the combination of sarcopenia with one of the following obesity criteria: BMI ≥30 kg/m2, waist circumference (WC) ≥ 88 cm in women or ≥ 102 cm in men, or the two highest sex-specific quintiles of body fat. Respiratory disease incidence and mortality were the outcomes. RESULTS: The mean follow-up period was 7.0 years. 5459 (3.2%) participants developed respiratory diseases and 780 (0.5%) died from respiratory diseases. Compared to individuals without obesity or sarcopenia, those who were obese (Hazard Ratio (HR): 1.13 [95 CI: 1.03; 1.23]), sarcopenic (HR: 1.23 [95% CI: 1.10; 1.36]) or sarcopenic obese (based on BMI) (HR: 1.51 [95% CI: 1.30; 1.77]), had a higher risk of respiratory disease incidence. However, the risk of respiratory disease mortality was higher in sarcopenic individuals and lower in obese individuals. No associations were identified between sarcopenic obesity and respiratory mortality (HR: 1.12 [95% CI: 0.76; 1.63]). Similar patterns were found when obesity was defined using WC or body fat. CONCLUSION: Obesity, sarcopenia and sarcopenic obesity were associated with a higher risk of respiratory disease incidence. However, while obesity was associated with lower, and sarcopenia with higher respiratory mortality risk, no associations between sarcopenic obesity and respiratory mortality were identified.
BACKGROUND:Sarcopenic obesity is defined as a combination of sarcopenia and obesity. Previous studies have shown a positive association between sarcopenia and respiratory disease, while other studies have identified that obese individuals have a lower risk for respiratory diseases. This study aimed to investigate the association of obesity, sarcopenia and sarcopenic obesity with respiratory disease incidence and mortality. METHODS: Data from 170,083 participants from the prospective UK Biobank study were included. Sarcopenic obesity was defined as the combination of sarcopenia with one of the following obesity criteria: BMI ≥30 kg/m2, waist circumference (WC) ≥ 88 cm in women or ≥ 102 cm in men, or the two highest sex-specific quintiles of body fat. Respiratory disease incidence and mortality were the outcomes. RESULTS: The mean follow-up period was 7.0 years. 5459 (3.2%) participants developed respiratory diseases and 780 (0.5%) died from respiratory diseases. Compared to individuals without obesity or sarcopenia, those who were obese (Hazard Ratio (HR): 1.13 [95 CI: 1.03; 1.23]), sarcopenic (HR: 1.23 [95% CI: 1.10; 1.36]) or sarcopenic obese (based on BMI) (HR: 1.51 [95% CI: 1.30; 1.77]), had a higher risk of respiratory disease incidence. However, the risk of respiratory disease mortality was higher in sarcopenic individuals and lower in obese individuals. No associations were identified between sarcopenic obesity and respiratory mortality (HR: 1.12 [95% CI: 0.76; 1.63]). Similar patterns were found when obesity was defined using WC or body fat. CONCLUSION:Obesity, sarcopenia and sarcopenic obesity were associated with a higher risk of respiratory disease incidence. However, while obesity was associated with lower, and sarcopenia with higher respiratory mortality risk, no associations between sarcopenic obesity and respiratory mortality were identified.
Authors: Elizabeth Benz; Sara R A Wijnant; Katerina Trajanoska; Johnmary T Arinze; Emmely W de Roos; Maria de Ridder; Ross Williams; Frank van Rooij; Katia M C Verhamme; M Arfan Ikram; Bruno H Stricker; Fernando Rivadeneira; Lies Lahousse; Guy G Brusselle Journal: ERJ Open Res Date: 2022-01-10
Authors: Laura Pérez-Campos Mayoral; Carlos Alberto Matias-Cervantes; Eduardo Pérez-Campos; Carlos Romero Díaz; Luis Ángel Laguna Barrios; María Del Socorro Pina Canseco; Margarito Martínez Cruz; Eduardo Pérez-Campos Mayoral; Carlos Josué Solórzano Mata; Francisco Javier Rodal Canales; Héctor Martínez Ruíz; María Teresa Hernández-Huerta Journal: Int J Mol Sci Date: 2022-07-27 Impact factor: 6.208