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Literature DB >> 32203194

A serine protease inhibitor suppresses autoimmune neuroinflammation by activating the STING/IFN-β axis in macrophages.

Giacomo Casella¹, Javad Rasouli¹, Keyonna Mason¹, Alexandra Boehm¹, Gaurav Kumar², Daniel Hwang¹, Rodolfo Thome¹, Larissa Ishikawa¹, Guang-Xian Zhang¹, Bogoljub Ciric¹, Abdolmohamad Rostami³.

Abstract

Entities: Gene

Year: 2020 PMID： 32203194 PMCID： PMC7784677 DOI： 10.1038/s41423-020-0405-z

Source DB: PubMed Journal: Cell Mol Immunol ISSN： 1672-7681 Impact factor: 11.530

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4 in total

1. Activation of the STING adaptor attenuates experimental autoimmune encephalitis.

Authors: Henrique Lemos; Lei Huang; Phillip R Chandler; Eslam Mohamed; Guilherme R Souza; Lingqian Li; Gabriela Pacholczyk; Glen N Barber; Yoshihiro Hayakawa; David H Munn; Andrew L Mellor
Journal: J Immunol Date: 2014-05-05 Impact factor: 5.422

2. Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system.

Authors: Marco Prinz; Hauke Schmidt; Alexander Mildner; Klaus-Peter Knobeloch; Uwe-Karsten Hanisch; Jenni Raasch; Doron Merkler; Claudia Detje; Ilona Gutcher; Jörg Mages; Roland Lang; Roland Martin; Ralf Gold; Burkhard Becher; Wolfgang Brück; Ulrich Kalinke
Journal: Immunity Date: 2008-05 Impact factor: 31.745

A serine protease inhibitor suppresses autoimmune neuroinflammation by activating the STING/IFN-β axis in macrophages.

1. Activation of the STING adaptor attenuates experimental autoimmune encephalitis.

2. Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system.

3. Bowman-Birk inhibitor suppresses autoimmune inflammation and neuronal loss in a mouse model of multiple sclerosis.

4. Soybean-derived Bowman-Birk Inhibitor (BBI) Inhibits HIV Replication in Macrophages.

Review 1. Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy.

2. Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis.

3. Matrine Inhibits CNS Autoimmunity Through an IFN-β-Dependent Mechanism.

Review 4. cGAS-STING-mediated IFN-I Response in Host Defense and Neuroinflammatory Diseases.